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  1. Computing and Explaining Query Answers over Inconsistent DL-Lite Knowledge Bases
    Autor*in: Bienvenu, Meghyn; Bourgaux, Camille; Goasdoué, François
    Erschienen: 2019
    Verlag:  HAL CCSD ; Association for the Advancement of Artificial Intelligence

    International audience ; Several inconsistency-tolerant semantics have been introduced for querying inconsistent description logic knowledge bases. The first contribution of this paper is a practical approach for computing the query answers under... mehr

     

    International audience ; Several inconsistency-tolerant semantics have been introduced for querying inconsistent description logic knowledge bases. The first contribution of this paper is a practical approach for computing the query answers under three well-known such semantics, namely the AR, IAR and brave semantics, in the lightweight description logic DL-Lite R. We show that query answering under the intractable AR semantics can be performed efficiently by using IAR and brave semantics as tractable approximations and encoding the AR entail-ment problem as a propositional satisfiability (SAT) problem. The second issue tackled in this work is explaining why a tuple is a (non-)answer to a query under these semantics. We define explanations for positive and negative answers under the brave, AR and IAR semantics. We then study the computational properties of explanations in DL-Lite R. For each type of explanation, we analyze the data complexity of recognizing (preferred) explanations and deciding if a given assertion is relevant or necessary. We establish tight connections between intractable explanation problems and variants of SAT, enabling us to generate explanations by exploiting solvers for Boolean satisfaction and optimization problems. Finally, we empirically study the efficiency of our query answering and explanation framework using a benchmark we built upon the well-established LUBM benchmark.

     
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    Übergeordneter Titel: ISSN: 1076-9757 ; Journal of Artificial Intelligence Research ; https://hal.inria.fr/hal-02066288 ; Journal of Artificial Intelligence Research, 2019, 64, pp.563-644. ⟨10.1613/jair.1.11395⟩
    Schlagworte: [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI]; [INFO.INFO-DB]Computer Science [cs]/Databases [cs.DB]
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    info:eu-repo/semantics/OpenAccess
  2. Comparison of Anti-Viral Activity of Frog Skin Anti-Microbial Peptides Temporin-Sha and [K3]SHa to LL-37 and Temporin-Tb against Herpes Simplex Virus Type 1
    Autor*in: Roy, Maëva; Lebeau, Lucie; Chessa, Céline; Damour, Alexia; Ladram, Ali; Oury, Bruno; Boutolleau, David; Bodet, Charles; Lévêque, Nicolas
    Erschienen: 2019
    Verlag:  HAL CCSD ; MDPI

    International audience ; Temporins are anti-microbial peptides synthesized in the skin of frogs of the Ranidae family. The few studies to date that have examined their anti-viral properties have shown that they have potential as anti-viral therapies.... mehr

     

    International audience ; Temporins are anti-microbial peptides synthesized in the skin of frogs of the Ranidae family. The few studies to date that have examined their anti-viral properties have shown that they have potential as anti-viral therapies. In this work, we evaluated the anti-herpes simplex virus type 1 (HSV-1) activity of the temporin-SHa (SHa) and its synthetic analog [K³]SHa. Human cathelicidin LL-37 and temporin-Tb (Tb), previously demonstrated to have anti-HSV-1 properties, were used as positive controls. We observed that SHa and [K³]SHa significantly inhibit HSV-1 replication in human primary keratinocytes when used at micromolar concentrations. This anti-viral activity was equivalent to that of Tb, but lower than that of LL-37. Transcriptomic analyses revealed that SHa did not act through the modulation of the cell innate immune response, but rather, displayed virucidal properties by reducing infectious titer of HSV-1 in suspension. In contrast, pre-incubation of the virus with LL-37 suggests that this peptide does not act directly on the viral particle at non-cytotoxic concentrations tested. The anti-HSV-1 activity of LL-37 appears to be due to the potentiation of cellular anti-viral defenses through the induction of interferon stimulated gene expression in infected primary keratinocytes. This study demonstrated that SHa and [K³]SHa, in addition to their previously reported antibacterial and antiparasitic activities, are direct-acting anti-HSV-1 peptides. Importantly, this study extends the little studied anti-viral attributes of frog temporins and offers perspectives for the development of new anti-HSV-1 therapies.

     
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    Übergeordneter Titel: ISSN: 1999-4915 ; Viruses ; https://hal.sorbonne-universite.fr/hal-02066789 ; Viruses, 2019, 11 (1), pp.77. ⟨10.3390/v11010077⟩
    Schlagworte: Tb; temporin; SHa; keratinocyte; cytotoxicity; anti-viral; immunomodulation; [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology; [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology
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    info:eu-repo/semantics/OpenAccess
  3. Les « black lists » du Conseil de Sécurité devant la Cour européenne des droits de l'homme ; Les « black lists » du Conseil de Sécurité devant la Cour européenne des droits de l'homme: (CEDH, 12 sept. 2012, n° 10593/08, Nada c/ Suisse, AJDA 2013. 165, chron. L. Burgorgue-Larsen ; RFDA 2013. 576, chron. H. Labayle, F. Sudre, X. Dupré de Boulois et L. Milano)
    Autor*in: Tinière, Romain
    Erschienen: 2013
    Verlag:  HAL CCSD ; Dalloz

    International audience ; L'arrêt Nada de la Cour européenne des droits de l'homme présente le double intérêt de constituer une avancée de la protection des droits fondamentaux dans le contentieux des sanctions ciblées, tout en laissant entrevoir des... mehr

     

    International audience ; L'arrêt Nada de la Cour européenne des droits de l'homme présente le double intérêt de constituer une avancée de la protection des droits fondamentaux dans le contentieux des sanctions ciblées, tout en laissant entrevoir des perspectives d'évolutions intéressantes pour la relation entre la Cour européenne et la Cour de justice. En effet, cet arrêt, qui présente quelques faiblesses dans son analyse des rapports de systèmes, doit nécessairement être analysé au regard de l'arrêt Kadi de la Cour de justice faisant ici figure pour les juges de Strasbourg de véritable standard de référence.

     
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    Übergeordneter Titel: ISSN: 0035-4317 ; EISSN: 2114-5288 ; RTDeur. Revue trimestrielle de droit européen ; https://hal.science/hal-02068803 ; RTDeur. Revue trimestrielle de droit européen, 2013, 3, pp.515-530
    Schlagworte: Union européenne; Relations extérieures; Sanction internationale; Conseil de sécurité des Nations unies; Liste noire; Droit et liberté fondamentaux; Droits de l'homme; Etat de guerre ou d'urgence; Terrorisme; [SHS.DROIT]Humanities and Social Sciences/Law
  4. Epithelial stratification shapes infection dynamics
    Autor*in: Murall, Carmen Lia; Jackson, Robert; Zehbe, Ingeborg; Boulle, Nathalie; Segondy, Michel; Alizon, Samuel
    Erschienen: 2019
    Verlag:  HAL CCSD ; Public Library of Science

    International audience ; Infections of stratified epithelia contribute to a large group of common diseases, such as dermatological conditions and sexually transmitted diseases. To investigate how epithelial structure affects infection dynamics, we... mehr

     

    International audience ; Infections of stratified epithelia contribute to a large group of common diseases, such as dermatological conditions and sexually transmitted diseases. To investigate how epithelial structure affects infection dynamics, we develop a general ecology-inspired model for stratified epithelia. Our model allows us to simulate infections, explore new hypotheses and estimate parameters that are difficult to measure with tissue cell cultures. We focus on two contrasting pathogens: Chlamydia trachomatis and Human papillomaviruses (HPV). Using cervicovaginal parameter estimates, we find that key infection symptoms can be explained by differential interactions with the layers, while clearance and pathogen burden appear to be bottom-up processes. Cell protective responses to infections (e.g. mucus trapping) generally lowered pathogen load but there were specific effects based on infection strategies. Our modeling approach opens new perspectives for 3D tissue culture experimental systems of infections and, more generally, for developing and testing hypotheses related to infections of stratified epithelia. Author summary Many epithelia are stratified in layers of cells and their infection can result in many pathologies, from rashes to cancer. It is important to understand to what extent the epi-thelial structure determines infection dynamics and outcomes. To aid experimental and clinical studies, we develop a mathematical model that recreates epithelial and infection dynamics. By applying it to a virus, human papillomavirus (HPV), and a bacteria, chla-mydia, we show that considering stratification improves our general understanding of disease patterns. For instance, the duration of infection can be driven by the rate at which the stem cells of the epithelium divide. Having a general model also allows us to investigate and compare hypotheses. This ecological framework can be modified to study specific pathogens or to estimate parameters from data generated in 3D skin cell culture experiments. PLOS ...

     
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  5. Mycobacterium chimaera Pulmonary Disease in Cystic Fibrosis Patients, France, 2010–2017
    Autor*in: Larcher, R.; Lounnas, Manon; Dumont, Yann; Michon, Anne-Laure; Bonzon, Lucas; Chiron, Raphaël; Carrière, Christian; Klouche, Kada; Godreuil, Sylvain
    Erschienen: 2019
    Verlag:  HAL CCSD ; Centers for Disease Control and Prevention

    International audience mehr

     

    International audience

     
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    Übergeordneter Titel: ISSN: 1080-6040 ; EISSN: 1080-6059 ; Emerging Infectious Diseases ; https://hal.science/hal-02069924 ; Emerging Infectious Diseases, 2019, 25 (3), pp.611-613. ⟨10.3201/eid2503.181590⟩
    Schlagworte: respiratory infections; tuberculosis and other mycobacteria; France; Mycobacterium avium complex; Mycobacterium chimaera; NTM; bacteria; cystic fibrosis; forced expiratory volume; forced vital capacity; nontuberculosis mycobacteria; pulmonary disease; [SDV]Life Sciences [q-bio]
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    info:eu-repo/semantics/OpenAccess
  6. Le dispositif français de transition vers l’économie circulaire institutionnalise-t-il un concept ? Une analyse transversale de discours
    Autor*in: Savy, Anne-Claire; N’diaye, Malick; Kessari, M.-E.
    Erschienen: 2019
    Verlag:  HAL CCSD ; ISTE OpenScience

    National audience ; This article, based on the theory of the social construction of reality, aims to understand if the construction of the plan of transition towards the circular economy (dispositif de transition vers l’économie circulaire – DTEC)... mehr

     

    National audience ; This article, based on the theory of the social construction of reality, aims to understand if the construction of the plan of transition towards the circular economy (dispositif de transition vers l’économie circulaire – DTEC) induces, in France, the institutionalization of a concept. The emerging concept of the circular economy (économie circulaire – EC) is situated in the context of debates on taking into account the impact of economic activity on nature (l’impact de l’activité économique sur la nature – IAEN). A corpus of French texts, participating in the DTEC since 2008, is the subject of a transversal contextualized analysis of discourse. The results show a diversified institutional job, in the theorization phase, without a common conceptualization of EC but converging on the need for a regulated territorial waste management policy. The institutionalization process is then discussed with the institutional change model. The interactions between institutional pressures to take the IAEN into account introduce the prospect of societal institutional change. ; Cet article vise à comprendre, avec les travaux issus de la théorie de la construction sociale du réel, si la construction du dispositif de transition vers l’économie circulaire (DTEC) induit, en France, l’institutionnalisation d’un concept. Les émergences du concept d’économie circulaire (EC) sont situées dans leur contexte de débats sur la prise en compte de l’impact de l’activité économique sur la nature (IAEN). Un corpus de textes français, participant au DTEC depuis 2008, fait l’objet d’une analyse de discours contextualisée transversale. Les résultats montrent un travail institutionnel diversifié, en phase de théorisation, sans conceptualisation commune sur l’EC mais convergeant sur la nécessité d’une politique territoriale régulée de gestion des déchets. Le processus d’institutionnalisation est ensuite discuté avec le modèle du changement institutionnel. Les interactions entre pressions institutionnelles de prise en compte de ...

     
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    Übergeordneter Titel: ISSN: 2399-8571 ; Technologie et innovation ; https://hal.umontpellier.fr/hal-02070650 ; Technologie et innovation, 2019, 4 (2), pp.1-25. ⟨10.21494/ISTE.OP.2019.0341⟩
    Schlagworte: SPEECH ANALYSIS; CIRCULAR ECONOMY; INSTITUTIONAL FRAMEWORK; TERRITORY; ADAPTATION TO CHANGE; ENVIRONMENTAL IMPACT; WASTE MANAGEMENT; IMPACT SUR L'ENVIRONNEMENT; GESTION DES DECHETS; ANALYSE DU DISCOURS; ECONOMIE CIRCULAIRE; CADRE INSTITUTIONNEL; CONCEPT; TERRITOIRE; ADAPTATION AU CHANGEMENT; TRANSITION; FRANCE; [SHS.GESTION]Humanities and Social Sciences/Business administration
  7. Gaia Data Release 2. Variable stars in the colour-absolute magnitude diagram
    Autor*in: Collaboration, Gaia; Eyer, L.; Rimoldini, L.; Audard, M.; Anderson, R.,; Nienartowicz, K.; Glass, F.; Marchal, O.; Grenon, M.; Mowlavi, N.; Holl, B.; Clementini, G.; Aerts, C.; Mazeh, T.; Evans, D.,; Szabados, L.; Brown, A,; Vallenari, A.; Prusti, T.; de Bruijne, J.; Babusiaux, C.; Biermann, M.; Jansen, F.; Jordi, C.; Klioner, S,; Lammers, U.; Lindegren, L.; Luri, X.; Mignard, F.; Panem, C.; Pourbaix, D.; Randich, S.; Sartoretti, P.; Siddiqui, H.; Soubiran, C.; van Leeuwen, F.; Walton, N.,; Arenou, Frédéric; Bastian, U.; Cropper, M.; Drimmel, R.; Katz, D.; Lattanzi, M.; Bakker, J.; Cacciari, C.; Barache, C.; Barata, C.; Barbato, D.; Barblan, F.; Barklem, P.
    Erschienen: 2019
    Verlag:  HAL CCSD ; EDP Sciences

    International audience ; Context. The ESA Gaia mission provides a unique time-domain survey for more than 1.6 billion sources with G 21 mag. Aims. We showcase stellar variability in the Galactic colour-absolute magnitude diagram (CaMD). We focus on... mehr

     

    International audience ; Context. The ESA Gaia mission provides a unique time-domain survey for more than 1.6 billion sources with G 21 mag. Aims. We showcase stellar variability in the Galactic colour-absolute magnitude diagram (CaMD). We focus on pulsating, eruptive, and cataclysmic variables, as well as on stars that exhibit variability that is due to rotation and eclipses. Methods. We describe the locations of variable star classes, variable object fractions, and typical variability amplitudes throughout the CaMD and show how variability-related changes in colour and brightness induce "motions". To do this, we use 22 months of calibrated photometric, spectro-photometric, and astrometric Gaia data of stars with a significant parallax. To ensure that a large variety of variable star classes populate the CaMD, we crossmatched Gaia sources with known variable stars. We also used the statistics and variability detection modules of the Gaia variability pipeline. Corrections for interstellar extinction are not implemented in this article. Results. Gaia enables the first investigation of Galactic variable star populations in the CaMD on a similar, if not larger, scale as was previously done in the Magellanic Clouds. Although the observed colours are not corrected for reddening, distinct regions are visible in which variable stars occur. We determine variable star fractions to within the current detection thresholds of Gaia. Finally, we report the most complete description of variability-induced motion within the CaMD to date. Conclusions. Gaia enables novel insights into variability phenomena for an unprecedented number of stars, which will benefit the understanding of stellar astrophysics. The CaMD of Galactic variable stars provides crucial information on physical origins of variability in a way that has previously only been accessible for Galactic star clusters or external galaxies. Future Gaia data releases will enable significant improvements over this preview by providing longer time series, more accurate ...

     
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    Übergeordneter Titel: ISSN: 0004-6361 ; EISSN: 1432-0756 ; Astronomy and Astrophysics - A&A ; https://hal.science/hal-02071443 ; Astronomy and Astrophysics - A&A, 2019, 623, pp.A110. ⟨10.1051/0004-6361/201833304⟩
    Schlagworte: [SDU.ASTR.GA]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Galactic Astrophysics [astro-ph.GA]; [SDU.ASTR.SR]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Solar and Stellar Astrophysics [astro-ph.SR]; [PHYS]Physics [physics]; [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
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    info:eu-repo/semantics/OpenAccess
  8. Selective sulfoxidation reactions with H2O2 catalyzed by Ti-containing SBA-15 materials
    Autor*in: Andrei, Radu Dorin; Cambruzzi, Nathan; Bonne, Magali; Bénédicte, Lebeau; Hulea, Vasile
    Erschienen: 2019
    Verlag:  HAL CCSD ; Springer Verlag

    International audience ; This contribution relates the behavior of Ti-SBA-15 catalysts in the sulfoxidation reaction with hydrogen peroxide under mild conditions (40–70 °C). Ti-SBA-15 samples with 1, 3 and 5 wt% of TiO2 have been prepared by grafting... mehr

     

    International audience ; This contribution relates the behavior of Ti-SBA-15 catalysts in the sulfoxidation reaction with hydrogen peroxide under mild conditions (40–70 °C). Ti-SBA-15 samples with 1, 3 and 5 wt% of TiO2 have been prepared by grafting SBA-15 silica with Ti(OiPr)4 in ethanol followed by calcination. Due to their mesopores, the Ti-containing catalysts accommodated large molecules like methyl-phenyl-sulfide, diphenylsulfide and dibenzothiophene, which were selectively oxidized into their corresponding sulfoxides and sulfones. The turnover frequency was correlated with the amount of the tetrahedral Ti atoms in the catalyst. During the oxidation process performed in batch mode, with acetonitrile or ethanol as solvent, the catalyst topology and texture were preserved, but the nature of the Ti species suffered some changes.

     
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    Übergeordneter Titel: ISSN: 1380-2224 ; EISSN: 1573-4854 ; Journal of Porous Materials ; https://hal.science/hal-02073786 ; Journal of Porous Materials, 2019, 26 (2), pp.533-539. ⟨10.1007/s10934-018-0640-1⟩
    Schlagworte: sulfoxidation; heterogeneous catalysis; [CHIM]Chemical Sciences; [CHIM.CATA]Chemical Sciences/Catalysis
  9. Does advertising the green benefits of products contribute to sustainable development goals? A quasi-experimental test of the dilution effect
    Autor*in: Grolleau, Gilles; Mzoughi, Naoufel; Sutan, Angela
    Erschienen: 2019
    Verlag:  HAL CCSD ; Wiley

    International audience ; Using two studies, we examine the dilution effect for green products, by testing whether advertising green benefits decreases their perceived instrumentality and thus harms sustainable development. We use a between‐subject... mehr

     

    International audience ; Using two studies, we examine the dilution effect for green products, by testing whether advertising green benefits decreases their perceived instrumentality and thus harms sustainable development. We use a between‐subject design and ask participants to evaluate the efficacy of a pen (Study 1) and a dish detergent (Study 2) with and without environmental attributes. Our results are inconsistent with the predictions of the dilution model because the perceived instrumentality of both products does not decrease when environmental benefits are added. Our findings are relevant for eco‐labeling given anecdotal evidence suggesting that adding green information can harm the perceived quality of products.

     
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    Übergeordneter Titel: ISSN: 0964-4733 ; EISSN: 1099-0836 ; Business Strategy and the Environment ; https://hal.science/hal-02074770 ; Business Strategy and the Environment, 2019, 28 (5), pp.786-793. ⟨10.1002/bse.2280⟩
    Schlagworte: green products; quality; behavioral economics; dilution model; eco-label; environmental information; [SHS.ECO]Humanities and Social Sciences/Economics and Finance; [SHS.GESTION]Humanities and Social Sciences/Business administration
  10. Postconditioning attenuates no-reflow in STEMI patients
    Autor*in: Mewton, Nathan; Thibault, Hélène; Roubille, François; Lairez, Olivier; Rioufol, Gilles; Sportouch, Catherine; Sanchez, Ingrid; Bergerot, Cyrille; Cung, Thien Tri; Finet, Gérard; Angoulvant, Denis; Revel, Didier; Bonnefoy-Cudraz, Eric; Elbaz, Meyer; Piot, Christophe; Sahraoui, Inesse; Croisille, Pierre; Ovize, Michel
    Erschienen: 2013
    Verlag:  HAL CCSD ; Springer Verlag

    International audience mehr

     

    International audience

     
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    Übergeordneter Titel: ISSN: 0300-8428 ; EISSN: 1435-1803 ; Basic Research in Cardiology ; https://hal.science/hal-02077072 ; Basic Research in Cardiology, 2013, 108 (6), ⟨10.1007/s00395-013-0383-8⟩
    Schlagworte: [SDV]Life Sciences [q-bio]; [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging; [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology; [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
  11. LSST: from Science Drivers to Reference Design and Anticipated Data Products
    Autor*in: Ivezić, Željko; Kahn, Steven M.; Tyson, J.Anthony; Abel, Bob; Acosta, Emily; Allsman, Robyn; Alonso, David; Alsayyad, Yusra; Anderson, Scott F.; Andrew, John; Angel, James Roger P.; Angeli, George Z.; Ansari, Reza; Antilogus, Pierre; Araujo, Constanza; Armstrong, Robert; Arndt, Kirk T.; Astier, Pierre; Aubourg, Éric; Auza, Nicole; Axelrod, Tim S.; Bard, Deborah J.; Barr, Jeff D.; Barrau, Aurelien; Bartlett, James G.; Bauer, Amanda E.; Bauman, Brian J.; Baumont, Sylvain; Bechtol, Ellen; Bechtol, Keith; Becker, Andrew C.; Becla, Jacek; Beldica, Cristina; Bellavia, Steve; Bianco, Federica B.; Biswas, Rahul; Blanc, Guillaume; Blazek, Jonathan; Blandford, Roger D.; Bloom, Josh S.; Bogart, Joanne; Bond, Tim W.; Booth, Michael T.; Borgland, Anders W.; Borne, Kirk; Bosch, James F.; Boutigny, Dominique; Brackett, Craig A.; Bradshaw, Andrew; Brandt, William Nielsen
    Erschienen: 2019
    Verlag:  HAL CCSD ; American Astronomical Society

    International audience ; We describe here the most ambitious survey currently planned in the optical, the Large Synoptic Survey Telescope (LSST). The LSST design is driven by four main science themes: probing dark energy and dark matter, taking an... mehr

     

    International audience ; We describe here the most ambitious survey currently planned in the optical, the Large Synoptic Survey Telescope (LSST). The LSST design is driven by four main science themes: probing dark energy and dark matter, taking an inventory of the solar system, exploring the transient optical sky, and mapping the Milky Way. LSST will be a large, wide-field ground-based system designed to obtain repeated images covering the sky visible from Cerro Pachón in northern Chile. The telescope will have an 8.4 m (6.5 m effective) primary mirror, a 9.6 deg2 field of view, a 3.2-gigapixel camera, and six filters (ugrizy) covering the wavelength range 320–1050 nm. The project is in the construction phase and will begin regular survey operations by 2022. About 90% of the observing time will be devoted to a deep-wide-fast survey mode that will uniformly observe a 18,000 deg2 region about 800 times (summed over all six bands) during the anticipated 10 yr of operations and will yield a co-added map to r ~ 27.5. These data will result in databases including about 32 trillion observations of 20 billion galaxies and a similar number of stars, and they will serve the majority of the primary science programs. The remaining 10% of the observing time will be allocated to special projects such as Very Deep and Very Fast time domain surveys, whose details are currently under discussion. We illustrate how the LSST science drivers led to these choices of system parameters, and we describe the expected data products and their characteristics.

     
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    Übergeordneter Titel: ISSN: 0004-637X ; EISSN: 1538-4357 ; The Astrophysical Journal ; https://hal.science/hal-02080729 ; The Astrophysical Journal, 2019, 873 (2), pp.111. ⟨10.3847/1538-4357/ab042c⟩
    Schlagworte: astrometry; cosmology: observations; Galaxy: general; methods: observational; stars: general; surveys; [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
  12. Multicentre, prospective, double-blind, randomised controlled clinical trial comparing different non-opioid analgesic combinations with morphine for postoperative analgesia: the OCTOPUS study
    Autor*in: Beloeil, H; Albaladejo, A; Sion, A.; Durand, M.; Martinez, V.; Lasocki, S.; Futier, E.; Verzili, D.; Minville, V.; Fessenmeyer, C.; Belbachir, A.; Aubrun, F.; Renault, A.; Bellissant, E.; Bedague, D.; Blanié, A.; Casez, M.; Chanques, Gerald; Chaize, C.; Dessertaine, G.; Ferré, F.; Gaide Chevronnay, L.; Hébrard, A.; Hespel, A.; Jaber, Samir; de Jong, Audrey; Lahjaouzi, A.; Marino, M.; Moury, H.; Neau, A.; Protar, D.; Rhem, D.; Rineau, E.; Robin, S.; Rossignol, E.; Soucemarianadin, M.; Veaceslav, S.
    Erschienen: 2019
    Verlag:  HAL CCSD ; Oxford University Press (OUP)

    International audience ; Background: Head-to-head comparisons of combinations of more than one non-opioid analgesic (NOA) with morphine alone, for postoperative analgesia, are lacking. The objective of this multicentre, randomised, double-blind... mehr

     

    International audience ; Background: Head-to-head comparisons of combinations of more than one non-opioid analgesic (NOA) with morphine alone, for postoperative analgesia, are lacking. The objective of this multicentre, randomised, double-blind controlled trial was to compare the morphine-sparing effects of different combinations of three NOAs-paracetamol (P), nefopam (N), and ketoprofen (K)-for postoperative analgesia. Methods: Patients from 10 hospitals were randomised to one of eight groups: control (C) received saline as placebo, P, N, K, PN, PK, NK, and PNK. Treatments were given intravenously four times a day during the first 48 h after surgery, and morphine patient-controlled analgesia was used as rescue analgesia. The outcome measures were morphine consumption, pain scores, and morphine-related side-effects evaluated 24 and 48 h after surgery. Results: Two hundred and thirty-seven patients undergoing a major surgical procedure were included between July 2013 and November 2016. Despite a failure to reach a calculated sample size, 24 h morphine consumption [median (interquartile range)] was significantly reduced in the PNK group [5 (1-11) mg] compared with either the C group [27 (11-42) mg; P<0.05] or the N group [21 (12-29) mg; P<0.05]. Results were similar 48 h after surgery. Patients experienced less pain in the PNK group compared with the C, N, and P groups. No difference was observed in the incidence of morphine-related side-effects. Conclusions: Combining three NOAs with morphine allows a significant morphine sparing for 48 h after surgery associated with superior analgesia the first 24 h when compared with morphine alone.

     
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    Übergeordneter Titel: ISSN: 0007-0912 ; EISSN: 1471-6771 ; British Journal of Anaesthesia ; https://hal.science/hal-02082182 ; British Journal of Anaesthesia, 2019, 122 (6), pp.e98-e106. &#x27E8;10.1016/j.bja.2018.10.058&#x27E9;
    Schlagworte: opioid sparing; ketoprofen; postoperative analgesia; morphine; non-opioid analgesics; nefopam; paracetamol; [SDV]Life Sciences [q-bio]
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    info:eu-repo/semantics/OpenAccess
  13. Avian malaria alters the dynamics of blood feeding in Culex pipiens mosquitoes
    Autor*in: Cornet, Stéphane; Nicot, Antoine; Rivero, Ana,; Gandon, Sylvain
    Erschienen: 2019
    Verlag:  HAL CCSD ; BioMed Central

    International audience ; Background: Some Plasmodium species have the ability to modify the behaviour of their mosquito vectors. This is thought to be an adaptive strategy that maximizes the parasite's transmission.Methods: The effect of Plasmodium... mehr

     

    International audience ; Background: Some Plasmodium species have the ability to modify the behaviour of their mosquito vectors. This is thought to be an adaptive strategy that maximizes the parasite's transmission.Methods: The effect of Plasmodium relictum infections on the blood feeding behaviour of Culex pipiens quinquefas-ciatus mosquitoes was monitored.Results: Plasmodium infections did not alter the proportion of blood fed mosquitoes but they did affect the dynamics and the size of the blood meal. Sporozoite-infected mosquitoes completed their blood meal 1.3 times later than uninfected mosquitoes and ended up with smaller blood meals.Conclusion: The potential adaptive nature of this manipulation of mosquito behaviour is discussed in the light of previous studies on other malaria models.

     
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    Übergeordneter Titel: ISSN: 1475-2875 ; Malaria Journal ; https://hal.umontpellier.fr/hal-02082598 ; Malaria Journal, 2019, 18, pp.82. &#x27E8;10.1186/s12936-019-2690-5&#x27E9;
    Schlagworte: Blood feeding; Culex pipiens; Plasmodium relictum; Malaria; Vector behaviour; [SDV.BA.ZI]Life Sciences [q-bio]/Animal biology/Invertebrate Zoology; [SDV.EE.IEO]Life Sciences [q-bio]/Ecology; environment/Symbiosis; [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology; [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE]
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    info:eu-repo/semantics/OpenAccess
  14. Insecticide resistance modifies mosquito response to DEET and natural repellents
    Autor*in: Deletre, Emilie; Martin, Thibaud; Duménil, Claire; Chandre, Fabrice
    Erschienen: 2019
    Verlag:  HAL CCSD ; BioMed Central

    International audience ; Background: Pyrethroid and organophosphate resistance in the malaria vector Anopheles gambiae has led to the search for not only alternative insecticides, but also repellent chemical compounds. However, little is known about... mehr

     

    International audience ; Background: Pyrethroid and organophosphate resistance in the malaria vector Anopheles gambiae has led to the search for not only alternative insecticides, but also repellent chemical compounds. However, little is known about the potential actions of repellents and the cross-resistance risk between insecticide and repellent compounds.Methods: Here we show the action of permethrin, DEET, geraniol, carvacrol, culminaldehyde and cinnamaldehyde against three A. gambiae strains: 'Kis' (Kisumu susceptible strain), 'KdrKis' (pyrethroid resistant strain) and 'AcerKis' (organophosphate resistant strain), the last two differing from the first by a mutation on the kdr and ace1 genes, respectively.Conclusions: Results from the DEET assays show it induced repellency for the resistant KdrKis and AcerKis strains but maintained irritancy for the susceptible strain. More generally, we show resistance genes modify the behavior of An. gambiae, increasing or decreasing the effectiveness of DEET and natural compounds, depending on the mutation. These findings offer a new avenue for research on the target and mechanism of repellent compounds. We discuss these findings in the context of vector control strategies.

     
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    Übergeordneter Titel: ISSN: 1756-3305 ; EISSN: 1756-3305 ; Parasites & Vectors ; https://hal.umontpellier.fr/hal-02082610 ; Parasites & Vectors, 2019, 12, pp.89. &#x27E8;10.1186/s13071-019-3343-9&#x27E9;
    Schlagworte: Mortality; Deterrent; Permethrin; Anopheles gambiae; Cinnamaldehyde; Geraniol; [SDV.BA.ZI]Life Sciences [q-bio]/Animal biology/Invertebrate Zoology; [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
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    info:eu-repo/semantics/OpenAccess
  15. A multicellular way of life for a multipartite virus
    Autor*in: Sicard, Anne; Pirolles, Elodie; Gallet, Romain; Vernerey, Marie-Stéphanie; Yvon, Michel; Urbino, Cica; Peterschmitt, Michel; Gutierrez, Serafin; Michalakis, Yannis; Blanc, Stéphane
    Erschienen: 2019
    Verlag:  HAL CCSD ; eLife Sciences Publication

    BGPI : équipe 2 / 5 ; International audience ; A founding paradigm in virology is that the spatial unit of the viral replication cycle is an individual cell. Multipartite viruses have a segmented genome where each segment is encapsidated separately.... mehr

     

    BGPI : équipe 2 / 5 ; International audience ; A founding paradigm in virology is that the spatial unit of the viral replication cycle is an individual cell. Multipartite viruses have a segmented genome where each segment is encapsidated separately. In this situation the viral genome is not recapitulated in a single virus particle but in the viral population. How multipartite viruses manage to efficiently infect individual cells with all segments, thus with the whole genome information, is a long-standing but perhaps deceptive mystery. By localizing and quantifying the genome segments of a nanovirus in host plant tissues we show that they rarely co-occur within individual cells. We further demonstrate that distinct segments accumulate independently in different cells and that the viral system is functional through complementation across cells. Our observation deviates from the classical conceptual framework in virology and opens an alternative possibility (at least for nanoviruses) where the infection can operate at a level above the individual cell level, defining a viral multicellular way of life.

     
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    Übergeordneter Titel: ISSN: 2050-084X ; EISSN: 2050-084X ; eLife ; https://hal.umontpellier.fr/hal-02082621 ; eLife, 2019, 8, pp.e43599. &#x27E8;10.7554/eLife.43599&#x27E9;
    Schlagworte: [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
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    creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess
  16. Remembering the Beginning: “All Electrons Are (Not) Alike” by Rosmarie Waldrop
    Autor*in: Bongers, Anna
    Erschienen: 2013

    Through a close reading of “All Electrons Are (Not) Alike,” the opening poem of Rosmarie Waldrop’s latest collection of prose poetry, Driven to Abstraction (2010), this paper shows how the poem deconstructs history and memory through criticism of... mehr

     

    Through a close reading of “All Electrons Are (Not) Alike,” the opening poem of Rosmarie Waldrop’s latest collection of prose poetry, Driven to Abstraction (2010), this paper shows how the poem deconstructs history and memory through criticism of language. Retelling the narration of the conquest of the Americas, “All Electrons Are (Not) Alike” calls into question the beginning of what was to become US American national identity. Putting Waldrop’s poem in the broader context of transnational criticism, I argue that its deconstructive poetic and philosophical use of language contributes to the transnational turn, helping to create the room that transnational criticism needs in order to come up with new, more appropriate ways of structuring literary studies.

     
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    Sprache: Englisch
    Medientyp: Aufsatz aus einer Zeitschrift
    Format: Online
    DDC Klassifikation: Literatur und Rhetorik (800); Amerikanische Literatur in in Englisch (810); Geschichte der Britischen Inseln (941); Geschichte Neuseelands (993)
    Schlagworte: americanstudies; literarystudies
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    L::CC BY 3.0 ; creativecommons.org/licenses/by/3.0/
  17. Opossum
    Autor*in: Murphy, Devin
    Erschienen: 2013

  18. Mosaic of Ashes: Poetic Responses to 9/11
    Autor*in: Mika, Katarzyna M.
    Erschienen: 2013

    By challenging and problematizing the definition of 9/11 as ‘the event,’ the article examines the extent to which the official discourse on the attacks, exemplified in speeches given by government representatives and based on preestablished binary... mehr

     

    By challenging and problematizing the definition of 9/11 as ‘the event,’ the article examines the extent to which the official discourse on the attacks, exemplified in speeches given by government representatives and based on preestablished binary symbolism, shaped poetic representations of 9/11. This article, by focusing on three anthologies of poetry, analyzes the diversity of poetic responses to 9/11 and the ways in which they engage with and respond to the government’s interpretation of the event and its impact on the redefinition of the sense of belonging to the national collective. The poetic heterogeneity testifies to the multiplicity of nonconsensual interpretations of the event, demonstrates its impact, and unveils the impossibility of providing any stable and shared definition of ‘the national collective.’ The attacks do not contribute to the creation of one uniting national narrative but signify multiple subjective experiences and, thus, elicit numerous distinct and discordant responses and memories of them.

     
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    Quelle: BASE Fachausschnitt AVL
    Sprache: Englisch
    Medientyp: Aufsatz aus einer Zeitschrift
    Format: Online
    DDC Klassifikation: Literatur und Rhetorik (800); Amerikanische Literatur in in Englisch (810); Geschichte der Britischen Inseln (941); Geschichte Neuseelands (993)
    Schlagworte: americanstudies; literarystudies
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    L::CC BY 3.0 ; creativecommons.org/licenses/by/3.0/
  19. The Old Man's Rocking Chair Is Moving Slower, Boy
    Autor*in: Greene, Randal Eldon
    Erschienen: 2013

  20. Narrativität als interdiziplinäre Schlüsselkategorie
    Autor*in: Nünning, Vera
    Erschienen: 2013

    Erzählungen bilden einen großen Teil des Gegenstandsbereichs einer Fülle von Wissenschaften; neben den Sozialwissenschaften befassen sich etwa Philosophie, Geschichtswissenschaft, Anthropologie, Psychologie und Rechtswissenschaft mit Narrationen.... mehr

     

    Erzählungen bilden einen großen Teil des Gegenstandsbereichs einer Fülle von Wissenschaften; neben den Sozialwissenschaften befassen sich etwa Philosophie, Geschichtswissenschaft, Anthropologie, Psychologie und Rechtswissenschaft mit Narrationen. Zudem hat sich in vielen Disziplinen die Einsicht durchgesetzt, dass die Form von Erzählungen maßgeblichen Einfluss auf die Bedeutung hat, die den erzählten Ereignissen zugewiesen wird. Der Artikel begründet die Relevanz einer interdisziplinären Auseinandersetzung mit dem Schlüsselkonzept der Narrativität anhand von drei Schritten: Zunächst erfolgt eine Begriffsdefinition, danach werden kurze Überlegungen zum interdisziplinären Potenzial der Erzähltheorie angestellt, und zum Schluss werden einige kognitive Funktionen von Erzählungen skizziert, wobei exemplarisch auf Empathie, ‚Theory of Mind‘ und die persuasive Kraft von Erzählungen eingegangen wird.

     
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    Quelle: BASE Fachausschnitt AVL
    Sprache: Deutsch
    Medientyp: Aufsatz aus einer Zeitschrift
    Format: Online
    DDC Klassifikation: Literatur und Rhetorik (800); Englische, altenglische Literaturen (820); Geschichte der Britischen Inseln (941); Geschichte Neuseelands (993)
    Schlagworte: englishstudies; culturalstudies; literarystudies
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    L::The Stacks License ; thestacks.libaac.de/rights
  21. Neurobiologische, psychologische und kulturwissenschaftliche Aspekte des kreativen Prozesses und ihre praktischen Konsequenzen
    Autor*in: Holm-Hadulla, Rainer M.; Barnow, Sven; Draguhn, Andreas; Nünning, Vera
    Erschienen: 2013

    Zu Beginn des 21. Jahrhunderts steht der Begriff Kreativität hoch im Kurs, und das Schöpferische wird sowohl für Individuen als auch Gesellschaften als lebensnotwendig angesehen. Es existieren viele Theorien und praktische Anwendungsvorschläge, die... mehr

     

    Zu Beginn des 21. Jahrhunderts steht der Begriff Kreativität hoch im Kurs, und das Schöpferische wird sowohl für Individuen als auch Gesellschaften als lebensnotwendig angesehen. Es existieren viele Theorien und praktische Anwendungsvorschläge, die einzelwissenschaftlich unterschiedliche Aspekte herausgreifen, dann jedoch zu weitgreifenden Folgerungen kommen, die durch das verwendete wissenschaftliche Paradigma nicht zu begründen sind. Deswegen ist es notwendig, die Grenzen der Gültigkeit einzelner Beiträge zu bestimmen und festzustellen, an welchen Stellen Erkenntnisse anderer Wissenschaftsbereiche relevant werden.Der vorliegende Beitrag versucht, die Potenziale und Begrenzungen neurobiologischer, psychologischer und kulturwissenschaftlicher Thesen auszuloten und Verbindungsmöglichkeiten aufzuzeigen. Dafür werden interdisziplinäre Leitbegriffe etabliert, die die einzelwissenschaftlichen Perspektiven erweitern und komplementieren könnten.

     
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    Sprache: Deutsch
    Medientyp: Aufsatz aus einer Zeitschrift
    Format: Online
    DDC Klassifikation: Literatur und Rhetorik (800); Englische, altenglische Literaturen (820); Geschichte der Britischen Inseln (941); Geschichte Neuseelands (993)
    Schlagworte: englishstudies; culturalstudies; literarystudies
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    L::The Stacks License ; thestacks.libaac.de/rights
  22. Toward an Ecopoetics of Randomness and Design: An Introduction: Hacia una eco-poética de la aleatoriedad y el diseño: Una introducción
    Autor*in: Bellarsi, Franca Anik; Rauscher, Judith
    Erschienen: 2019

    What ecopoetics is and what it does, how it relates to but also exceeds ecopoetry, and the nature of its relationship to the more general poiesis (?making”) at work in the material universe remain open and thorny questions. Moreover, what are the... mehr

     

    What ecopoetics is and what it does, how it relates to but also exceeds ecopoetry, and the nature of its relationship to the more general poiesis (?making”) at work in the material universe remain open and thorny questions. Moreover, what are the insights from the more specialised field of experimental ecopoetry that we may bring to our understanding of ecopoetics in general, whatever the genre and material support on which environmentally-inflected poiesis deploys itself? As this Special Focus section shows, one may begin to answer such questions by taking into account notions of randomness and design, concepts that operate in experimental texts and the material universe at large, but which have not been sufficiently foregrounded in the ongoing theoretical debate on ecopoetics. Any sustained effort to understand how randomness and design permeate ecopoetics requires a vision of ecopoetics that goes beyond (eco)poetry. Providing some examples of what such a broader vision of ecopoetics might look like is also one of the goals of this Special Focus. Unfolding in three stages, this introductory essay will first map out the elements and orientations that inform the debates on ecopoetics, while also touching upon the adjacent territories of geopoetics, zoopoetics, écopoétique and Ökopoetik. A second part will meditate on the elusive concepts of randomness and design, and on how ecopoetics might be considered a form of adaptive mapping of their ever-fluid entanglement. The third part, finally, presents the contributions to this Special Focus section and surveys the different facets of the co-constitutive operations of randomness and design explored in each.

     
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    Sprache: Englisch; Spanisch
    Medientyp: Aufsatz aus einer Zeitschrift
    Format: Online
    DDC Klassifikation: Literatur und Rhetorik (800); Geschichte der Britischen Inseln (941); Geschichte Neuseelands (993)
    Schlagworte: americanstudies; environmentalstudies; literarystudies
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    L::CC BY-NC 3.0 ; creativecommons.org/licenses/by-nc/3.0/
  23. Assessments of the Urban Experience: Toni Morrison's Jazz and T. S. Eliot's The Waste Land
    Autor*in: Mayer, Sylvia
    Erschienen: 1998

  24. Introduction: Starting Off a New Decade: On Alternatives, Contestations, and an Infinity of Possibility
    Autor*in: Er, Öykü; Gerlach, Laura; Vossen, Hannah; Hussey, Ben; Navin, Margaret; Puccio, Daniele; Vogelsburg, Anne
    Erschienen: 2019

  25. Ceremony Found: Sylvia Wynter’s Hybrid Human and Leslie Marmon Silko’s Ceremony
    Autor*in: Obst, Anthony James
    Erschienen: 2019

    This paper engages Sylvia Wynter’s theory of the hybrid human as a prism for reading Leslie Marmon Silko’s 1977 novel Ceremony. Wynter’s work aims at decolonizing Western categories of knowledge, positing the notion of an Autopoetic Turn/Overturn to... mehr

     

    This paper engages Sylvia Wynter’s theory of the hybrid human as a prism for reading Leslie Marmon Silko’s 1977 novel Ceremony. Wynter’s work aims at decolonizing Western categories of knowledge, positing the notion of an Autopoetic Turn/Overturn to unsettle the coloniality of Man as an epistemo-ontological category. The epistemic break Wynter envisions to catalyze this unsettling involves an understanding of the human as a hybrid species, made up of biological as well as symbolic life, bios and mythos. Such an understanding of the human is revealed in Silko’s novel, as its protagonist, Tayo, undergoes a ritual of ceremonial healing that mirrors Wynter’s Autopoetic Turn/Overturn, disentangling himself from Western modes of knowledge by scripting a new story for himself and his people. Drawing on two of Wynter’s essays that carry “Ceremony” in their titles, my paper explores the intersections between Wynter’s theory and Silko’s fiction. By showing how Silko fictionally reenvisions new futures of being hybridly human beyond the category of Man, this essay points to epistemic pathways of decoloniality not predicated on anger.

     
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    Sprache: Englisch
    Medientyp: Aufsatz aus einer Zeitschrift
    Format: Online
    DDC Klassifikation: Literatur und Rhetorik (800); Amerikanische Literatur in in Englisch (810); Geschichte der Britischen Inseln (941); Geschichte Neuseelands (993)
    Schlagworte: americanstudies; indigenousstudies; literarystudies
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    L::CC BY 3.0 ; creativecommons.org/licenses/by/3.0/