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  1. <<A>> connection not made
    the Chapel Point Historic Site Project
    Erschienen: 2003
    Verlag:  The Association for Living History, Farm and Agricultural Museums, North Bloomfield, Ohio

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    Sprache: Englisch
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    Übergeordneter Titel: Enthalten in: Proceedings of the ... Conference and Annual Meeting / ALHFAM - The Association for Living History, Farm and Agricultural Museums; North Bloomfield, Ohio, 2003; 25.2003: Seite 89-93
    Schlagworte: Array
  2. Frederick Beiser: German Idealism. The Struggle against Subjectivism, 1781-1801
    Erschienen: 2004
    Verlag:  Humboldt-Universität zu Berlin

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    Sprache: Englisch
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    Format: Online
    DDC Klassifikation: Literatur und Rhetorik (800)
    Schlagworte: Rhetorik; Literaturwissenschaft
  3. What's Gender Got to do With it?: A Phenomenology of Romantic Love
    Erschienen: 1999
    Verlag:  Humboldt-Universität zu Berlin

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    Format: Online
    DDC Klassifikation: Literatur und Rhetorik (800)
    Schlagworte: Rhetorik; Literaturwissenschaft
  4. Ralf Klausnitzer: Blaue Blume unterm Hakenkreuz. Die Rezeption der deutschen literarischen Romantik im Dritten Reich
    Erschienen: 2003
    Verlag:  Humboldt-Universität zu Berlin

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    DDC Klassifikation: Literatur und Rhetorik (800)
    Schlagworte: Rhetorik; Literaturwissenschaft
  5. „Und wer bin ich denn?” Wordplay and Identity in Tieck's William Lovell
    Autor*in: Tucker, Brian
    Erschienen: 2004
    Verlag:  Humboldt-Universität zu Berlin

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    DDC Klassifikation: Literatur und Rhetorik (800)
    Schlagworte: Rhetorik; Literaturwissenschaft
  6. Influences of postural alterations on the hemodynamic of the gait in patients with saphenous incompetence. A preliminary study

    OBJECTIVES: The aim of this study is to verify whether the postural alterations can influence the development of the varicose disease with unilateral and bilateral saphenous incompetence. MATERIALS AND METHODS: 39 patients suffering from saphenous... mehr

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    OBJECTIVES: The aim of this study is to verify whether the postural alterations can influence the development of the varicose disease with unilateral and bilateral saphenous incompetence. MATERIALS AND METHODS: 39 patients suffering from saphenous incompetence diagnosed by hemodynamic study with eco-color doppler (20 patients with bilateral venous insufficiency (VI), 19 patients with unilateral VI) have performed the gait analysis though wireless inertial sensor and baropodometry to assess the plantar pressure distribution both statically and dynamically. RESULTS: The 68% and the 60% of subjects suffering from unilateral or bilateral VI present a plantar pressure dysfunction a single foot or both feet in static and/or in dynamic. In 63% of subjects with unilateral VI the propulsion is reduced on the lower limb damaged. The number of asymmetries in walking and dysfunctions in planar pressure in both groups has been calculated. The average number of asymmetries in walking in the group of patients with unilateral VI is significantly greater (p-value=0.0075) compared to the group of patients with bilateral VI. CONCLUSIONS: Plantar pressure and increased valvo-muscular pump pressure (VMPP) are not the main etiological factors that modify the hemodynamic in walking. In unilateral cases the postural alterations may contribute to worsening or to appearance of the varicose veins. Postural disorders treatment in children of phlebopaths during the childhood could maintain the mild condition of varicose disease silent. The treatment in adults suffering from unilateral VI may reduce or prevent the appearance of relapses KEY WORDS: Gait analysis, Hemodynamic of the gait, Postural alterations, Saphenous incompetence, Venous insufficiency.

     

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  7. Next-generation care pathways for allergic rhinitis and asthma multimorbidity: A model for multimorbid non-communicable diseases—Meeting Report (Part 2)
  8. Next-generation care pathways for allergic rhinitis and asthma multimorbidity: A model for multimorbid non-communicable diseases—Meeting Report (Part 1)
  9. Mobile Technology in Allergic Rhinitis: Evolution in Management or Revolution in Health and Care?

    Smart devices and Internet-based applications (apps) are largely used in allergic rhinitis and may help to address some unmet needs. However, these new tools need to first of all be tested for privacy rules, acceptability, usability, and... mehr

     

    Smart devices and Internet-based applications (apps) are largely used in allergic rhinitis and may help to address some unmet needs. However, these new tools need to first of all be tested for privacy rules, acceptability, usability, and cost-effectiveness. Second, they should be evaluated in the frame of the digital transformation of health, their impact on health care delivery, and health outcomes. This review (1) summarizes some existing mobile health apps for allergic rhinitis and reviews those in which testing has been published, (2) discusses apps that include risk factors of allergic rhinitis, (3) examines the impact of mobile health apps in phenotype discovery, (4) provides real-world evidence for care pathways, and finally (5) discusses mobile health tools enabling the digital transformation of health and care, empowering citizens, and building a healthier society.

     

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    Schlagworte: App; Digital transformation of health; MASK; mHealth; Mobile technology; Rhiniti; Delivery of Health Care; Europe; Human; Mobile Application; Phenotype; Rhinitis; Allergic; Risk Factor; Telemedicine; Smartphone
  10. Dietary polyphenols and type 2 diabetes: Human Study and Clinical Trial

    Significant evidence from epidemiological investigations showed that dietary polyphenols might manage and prevent type 2 diabetes (T2D). This review summarizes human studies and clinical trials of polyphenols as anti-diabetic agents. Polyphenols from... mehr

     

    Significant evidence from epidemiological investigations showed that dietary polyphenols might manage and prevent type 2 diabetes (T2D). This review summarizes human studies and clinical trials of polyphenols as anti-diabetic agents. Polyphenols from coffee, guava tea, whortleberry, olive oil, propolis, chocolate, red wine, grape seed, and cocoa have been reported to show anti-diabetic effects in T2D patients through increasing glucose metabolism, improving vascular function as well as reducing insulin resistance and HbA1c level. However, individual flavonoid or isoflavonoid compounds appear to have no therapeutic effect on diabetes, based on the limited clinical data. Preliminary clinical trials provided evidence that resveratrol had anti-diabetic activity in humans by improving glycemic control in subjects with insulin resistance. Besides, anthocyanins exhibited anti-diabetic properties by reducing blood glucose and HbA1c levels or the improvement of insulin secretion and resistance. The structure-activity relationship of polyphenols as anti-diabetic agents in humans has been rarely reported.

     

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    Schlagworte: clinical trial; Dietary polyphenol; human Study; Blood Glucose; Clinical Trials as Topic; Diabetes Mellitus; Human; Hypoglycemic Agent; Polyphenol; Diet; Insulin Resistance
  11. Shedding light on the migratory patterns of the Amazonian goliath catfish, Brachyplatystoma platynemum , using otolith 87 Sr/ 86 Sr analyses

    International audience ; In the Amazon, migratory catfishes of the genus Brachyplatystoma are apex predators that are important for fisheries and conservation. The life cycle of Brachyplatystoma platynemum Boulenger, 1898 is poorly known, although it... mehr

     

    International audience ; In the Amazon, migratory catfishes of the genus Brachyplatystoma are apex predators that are important for fisheries and conservation. The life cycle of Brachyplatystoma platynemum Boulenger, 1898 is poorly known, although it has been hypothesized to be very similar to that of Brachyplatystoma rousseauxii Castelnau, 1855, which uses the entire length of the Amazon basin to complete its life cycle (from the Andes to the estuary). This study provides the first data on the migratory patterns of B. platynemum at the individual level using otolith microchemistry. In total, 94 individuals were sampled close to major breeding areas in the Amazon basin (78 fish from the middle and upper Madeira River and 14 fish from the upper Amazon), and their lifetime movements were assessed by measuring variations in 87 Sr/ 86 Sr along transverse sections of their otoliths (ear stones), using laser ablation multi-collector mass spectrometry (LA-MC-ICP-MS). The migrations of B. platynemum are not as extensive as those of B. rousseauxii, and do not involve natal homing. Furthermore, the estuary is not a nursery area, at least for fish hatched in the Madeira. Nevertheless, B. platynemum migrates several thousand kilometres within the Amazon basin, with transboundary displacements between at least Bolivia, Brazil, and Peru. Current and planned hydroelectric development in the Amazon basin will severely disrupt both migration and access to breeding grounds, ultimately affecting the recruitment and population dynamics of these apex predators. The conservation of B. platynemum is crucial for the stability of the Amazonian aquatic food webs. This requires building effective fish passage on the two existing Madeira dams and considering alternative options to the large-scale hydropower development in the Amazon basin

     

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    Übergeordneter Titel: ISSN: 1052-7613 ; EISSN: 1099-0755 ; Aquatic Conservation: Marine and Freshwater Ecosystems ; https://hal.science/hal-02055491 ; Aquatic Conservation: Marine and Freshwater Ecosystems, 2019, 29 (3), pp.397-408. &#x27E8;10.1002/aqc.3046&#x27E9;
    Schlagworte: fish; conservation evaluation; catchment; fishing; hydroelectric dams; migration; river; [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry; [CHIM.ANAL]Chemical Sciences/Analytical chemistry; [CHIM.POLY]Chemical Sciences/Polymers; [CHIM.MATE]Chemical Sciences/Material chemistry
  12. Multicenter Evaluation of a Novel Immunochromatographic Test for Anti-aspergillus IgG Detection

    International audience ; Aspergillus sp. fungi cause various diseases in both immunocompetent and immunocompromised patients. The most frequent Aspergillus disorders include chronic pulmonary aspergillosis (CPA), a life-threatening disease that... mehr

     

    International audience ; Aspergillus sp. fungi cause various diseases in both immunocompetent and immunocompromised patients. The most frequent Aspergillus disorders include chronic pulmonary aspergillosis (CPA), a life-threatening disease that affects at least 3 million people worldwide, and allergic bronchopulmonary aspergillosis (ABPA), which affects approximately 4.8 million severe asthmatic patients globally. Diagnosis of such diseases involves IgG serological testing; however, the currently available anti-Aspergillus IgG detection assays are inappropriate for resource-poor laboratory settings, as they are expensive, rely on automated procedures, and require stable electrical power. Therefore, accurate CPA or ABPA diagnosis facilities are lacking in most low- and middle-income countries. We evaluated a novel anti-Aspergillus antibody immunochromatographic test (ICT) that requires minimal laboratory equipment. Two evaluations were performed a single-center 4-month prospective study in a French reference laboratory (44 cases/257 patients) and a retrospective study in five French reference laboratories (262 cases and 188 controls). We estimated the ICT indices for the diagnosis of chronic aspergillosis, and the test results were compared to those of anti-Aspergillus IgG immunoblot (IB) assay. Of the 713 patients included in the study, 306 had chronic aspergillosis. Test sensitivity and specificity were 88.9%(95% CI[85-92]) and 96.3%(95% CI[94-98]) for the ICT and 93.1% (95% CI[90-96]) and 94.3% (95% CI[92-96]) for the IB, respectively. Agreement between the two assays was almost perfect (kappa = 0.86). As this ICT displays good diagnostic performance and complies with the ASSURED (Affordable, Sensitive, Specific, User-friendly, Equipment-free, and Delivered) criteria, we concluded that this anti-Aspergillus antibody ICT can be used to diagnose Aspergillus diseases in resource-poor settings.

     

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    Übergeordneter Titel: ISSN: 2235-2988 ; Frontiers in Cellular and Infection Microbiology ; https://hal-univ-rennes1.archives-ouvertes.fr/hal-02061628 ; Frontiers in Cellular and Infection Microbiology, 2019, 9, pp.12. &#x27E8;10.3389/fcimb.2019.00012&#x27E9;
    Schlagworte: immunochromatography; allergic broncho-pulmonary aspergillosis; sensitivity; Aspergillus serology; point-of-care; chronic pulmonary aspergillosis; specificity; [SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology; [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
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    creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess

  13. Cranial nerve involvement in patients with MOG antibody–associated disease

    International audience mehr

     

    International audience

     

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    Übergeordneter Titel: Neurology - Neuroimmunology Neuroinflammation ; https://hal.science/hal-02063145 ; Neurology - Neuroimmunology Neuroinflammation, 2019, 6 (2), pp.e543. &#x27E8;10.1212/NXI.0000000000000543&#x27E9;
    Schlagworte: [SDV]Life Sciences [q-bio]
  14. Comparison of Mycobacterium ulcerans (Buruli ulcer) and Leptospira sp. (Leptospirosis) dynamics in urban and rural settings

    International audience ; Background: Zoonotic pathogens respond to changes in host range and/or pathogen, vector and host ecology. Environmental changes (biodiversity, habitat changes, variability in climate), even at a local level, lead to... mehr

     

    International audience ; Background: Zoonotic pathogens respond to changes in host range and/or pathogen, vector and host ecology. Environmental changes (biodiversity, habitat changes, variability in climate), even at a local level, lead to variability in environmental pathogen dynamics and can facilitate their transmission from natural reservoirs to new susceptible hosts. Whilst the environmental dynamics of aquatic bacteria are directly linked to seasonal changes of their habitat they also rely on the ecological processes underpining their transmission. However data allowing the comparison of these ecological processes are lacking. Here we compared the environmental dynamics of generalist and vector-borne aquatic bacterial pathogens in the same unit of time and space, and across rural and urban habitats in French Guiana (South America).Principal findings: Using Leptospira sp. and Mycobacterium ulcerans we performed an environmental survey that allowed the detection of both pathogens in urban vs. rural areas, and during rainy vs. dry weather conditions. All samples were subjected to qPCR amplifications of LipL32 (Leptospira sp.) and IS2404 and KR (M. ulcerans) genetic markers. We found (i) a greater presence of M. ulcerans in rural areas compared with Leptospira sp., (ii) that modified urban environments were more favourable to the establishment of both pathogens, (iii) that Leptospira sp. presence was enhanced during the rainy season and M. ulcerans during the dry period, and (iv) differences in the spatial distribution of both bacteria across urban sites, probably due to the mode of dissemination of each pathogen in the environment.Conclusions: We propose that in French Guiana simplified and modified urban ecosystems might favour leptospirosis and Buruli ulcer emergence and transmission. Moreover, disease risk was also constrained by seasonality. We suggest that the prevention of aquatic bacterial disease emergence in impoverished urban areas of developing countries would benefit from seasonal diseases ...

     

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    Übergeordneter Titel: ISSN: 1935-2727 ; EISSN: 1935-2735 ; PLoS Neglected Tropical Diseases ; https://hal.umontpellier.fr/hal-02063496 ; PLoS Neglected Tropical Diseases, 2019, 13 (1), pp.e0007074. &#x27E8;10.1371/journal.pntd.0007074&#x27E9;
    Schlagworte: [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie; [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology; [SDV.EE.SANT]Life Sciences [q-bio]/Ecology; environment/Health; [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
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  15. Field evaluation of seasonal trends in relative population sizes and dispersal pattern of Aedes albopictus males in support of the design of a sterile male release strategy

    International audience ; Background: To develop an efficient sterile insect technique (SIT) programme, the number of sterile males to release, along with the spatial and temporal pattern of their release, has to be determined. Such parameters could... mehr

     

    International audience ; Background: To develop an efficient sterile insect technique (SIT) programme, the number of sterile males to release, along with the spatial and temporal pattern of their release, has to be determined. Such parameters could be estimated from a reliable estimation of the wild population density (and its temporal variation) in the area to treat. Here, a series of mark-release-recapture experiments using laboratory-reared and field-derived Aedes albopictus males were carried out in Duparc, a selected pilot site for the future application of SIT in the north of La Reunion Island.Methods: The dispersal, longevity of marked males and seasonal fluctuations in the population size of native mosquitoes were determined from the ratio of marked to unmarked males caught in mice-baited BG-Sentinel traps. The study was conducted during periods of declining population abundance (April), lowest abundance (September) and highest abundance (December).Results: According to data collected in the first 4 days post-release, the Lincoln index estimated population size as quite variable, ranging from 5817 in April, to 639 in September and 5915 in December. Calculations of daily survival probability to 4 days after release for field and laboratory males were 0.91 and 0.98 in April, respectively, and 0.88 and 0.84 in September, respectively. The mean distance travelled (MDT) of released field males were 46 m, 67 m and 37 m for December, April and September experiments, respectively. For released laboratory males, the MDT was 65 m and 42 m in April and September, respectively.Conclusions: Theoretically, the most efficient release programme should be started in July/August when the mosquito population size is the lowest (c.600 wild males/ha relative to 5000 wild males estimated for December and April), with a weekly release of 6000 males/ha. The limited dispersal of Ae. albopictus males highlights the nessecity for the widespread release of sterile males over multiple sites and in a field setting to avoid ...

     

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    Übergeordneter Titel: ISSN: 1756-3305 ; EISSN: 1756-3305 ; Parasites & Vectors ; https://hal.umontpellier.fr/hal-02063510 ; Parasites & Vectors, 2019, 12, pp.81. &#x27E8;10.1186/s13071-019-3329-7&#x27E9;
    Schlagworte: Male mosquito; Sterile insect technique (SIT); Mark-release-recapture; [SDE.BE]Environmental Sciences/Biodiversity and Ecology; [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology
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  16. Genome-wide profiling of human papillomavirus DNA integration in liquid-based cytology specimens from a Gabonese female population using HPV capture technology

    International audience ; Human papillomavirus (HPV) is recognised as the cause of precancerous and cancerous cervical lesions. Furthermore, in high-grade lesions, HPV is frequently integrated in the host cell genome and associated with the partial or... mehr

     

    International audience ; Human papillomavirus (HPV) is recognised as the cause of precancerous and cancerous cervical lesions. Furthermore, in high-grade lesions, HPV is frequently integrated in the host cell genome and associated with the partial or complete loss of the E1 and E2 genes, which regulate the activity of viral oncoproteins E6 and E7. In this study, using a double-capture system followed by high-throughput sequencing, we determined the HPV integration status present in liquid-based cervical smears in an urban Gabonese population. The main inclusion criteria were based on cytological grade and the detection of the HPV16 genotype using molecular assays. The rate of HPV integration in the host genome varied with cytological grade: 85.7% (6/7), 71.4% (5/7), 66.7% (2/3) 60% (3/5) and 30.8% (4/13) for carcinomas, HSIL, ASCH, LSIL and ASCUS, respectively. For high cytological grades (carcinomas and HSIL), genotypes HPV16 and 18 represented 92.9% of the samples (13/14). The integrated form of HPV16 genotype was mainly found in high-grade lesions in 71.4% of samples regardless of cytological grade. Minority genotypes (HPV33, 51, 58 and 59) were found in LSIL samples, except HPV59, which was identified in one HSIL sample. Among all the HPV genotypes identified after double capture, 10 genotypes (HPV30, 35, 39, 44, 45, 53, 56, 59, 74 and 82) were detected only in episomal form. Our study revealed that the degree of HPV integration varies with cervical cytological grade. The integration event might be a potential clinical prognostic biomarker for the prediction of the progression of neoplastic lesions.

     

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    Übergeordneter Titel: ISSN: 2045-2322 ; EISSN: 2045-2322 ; Scientific Reports ; https://hal.umontpellier.fr/hal-02063523 ; Scientific Reports, 2019, 9, pp.1504. &#x27E8;10.1038/s41598-018-37871-2&#x27E9;
    Schlagworte: [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
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    info:eu-repo/semantics/OpenAccess

  17. Implications of insecticide resistance for malaria vector control with long-lasting insecticidal nets: evidence from health facility data from Benin

    International audience ; Background: Insecticide-based interventions have averted more than 500 million malaria cases since 2000, but insecticide resistance in mosquitoes could bring about a rebound in disease and mortality. This study investigated... mehr

     

    International audience ; Background: Insecticide-based interventions have averted more than 500 million malaria cases since 2000, but insecticide resistance in mosquitoes could bring about a rebound in disease and mortality. This study investigated whether insecticide resistance was associated with increased incidence of clinical malaria.Methods: In an area of southern Benin with insecticide resistance and high use of insecticide-treated nets (ITNs), malaria morbidity and insecticide resistance were measured simultaneously in 30 clusters (villages or collections of villages) multiple times over the course of 2 years. Insecticide resistance frequencies were measured using the standard World Health Organization bioassay test. Malaria morbidity was measured by cases recorded at health facilities both in the whole population using routinely collected data and in a passively followed cohort of children under 5 years old.Results: There was no evidence that incidence of malaria from routinely collected data was higher in clusters with resistance frequencies above the median, either in children aged under 5 (RR = 1.27 (95% CI 0.81-2.00) p = 0.276) or in individuals aged 5 or over (RR = 1.74 (95% CI 0.91-3.34) p = 0.093). There was also no evidence that incidence was higher in clusters with resistance frequencies above the median in the passively followed cohort (RR = 1.11 (0.52-2.35) p = 0.777).Conclusions: This study found no association between frequency of resistance and incidence of clinical malaria in an area where ITNs are the principal form of vector control. This may be because, as other studies have shown, ITNs continue to offer some protection from malaria even in the presence of insecticide resistance. Irrespective of resistance , nets provide only partial protection so the development of improved or supplementary vector control tools is required to reduce Africa's unacceptably high malaria burden.

     

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    Übergeordneter Titel: ISSN: 1475-2875 ; Malaria Journal ; https://hal.umontpellier.fr/hal-02063564 ; Malaria Journal, 2019, 18, pp.37. &#x27E8;10.1186/s12936-019-2656-7&#x27E9;
    Schlagworte: Malaria; Insecticide; Resistance; Pyrethroid; Vector; [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie; [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
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  18. Detection of novel astroviruses among rodents of Gabon, Central Africa

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    Übergeordneter Titel: ISSN: 1567-1348 ; EISSN: 1567-7257 ; Infection, Genetics and Evolution ; https://hal.umontpellier.fr/hal-02063571 ; Infection, Genetics and Evolution, 2019, 68, pp.43-46. &#x27E8;10.1016/j.meegid.2018.12.003&#x27E9;
    Schlagworte: [SDV.BID]Life Sciences [q-bio]/Biodiversity
  19. Tuning and monitoring the electronic structure of carbon nanotubes
    Erschienen: 1999
    Verlag:  HAL CCSD ; Elsevier

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    Übergeordneter Titel: ISSN: 0009-2614 ; Chemical Physics Letters ; https://hal.science/hal-02063810 ; Chemical Physics Letters, 1999, 305 (5-6), pp.370-374. &#x27E8;10.1016/S0009-2614(99)00399-1&#x27E9;
    Schlagworte: [PHYS]Physics [physics]
  20. Computing and Explaining Query Answers over Inconsistent DL-Lite Knowledge Bases
    Erschienen: 2019
    Verlag:  HAL CCSD ; Association for the Advancement of Artificial Intelligence

    International audience ; Several inconsistency-tolerant semantics have been introduced for querying inconsistent description logic knowledge bases. The first contribution of this paper is a practical approach for computing the query answers under... mehr

     

    International audience ; Several inconsistency-tolerant semantics have been introduced for querying inconsistent description logic knowledge bases. The first contribution of this paper is a practical approach for computing the query answers under three well-known such semantics, namely the AR, IAR and brave semantics, in the lightweight description logic DL-Lite R. We show that query answering under the intractable AR semantics can be performed efficiently by using IAR and brave semantics as tractable approximations and encoding the AR entail-ment problem as a propositional satisfiability (SAT) problem. The second issue tackled in this work is explaining why a tuple is a (non-)answer to a query under these semantics. We define explanations for positive and negative answers under the brave, AR and IAR semantics. We then study the computational properties of explanations in DL-Lite R. For each type of explanation, we analyze the data complexity of recognizing (preferred) explanations and deciding if a given assertion is relevant or necessary. We establish tight connections between intractable explanation problems and variants of SAT, enabling us to generate explanations by exploiting solvers for Boolean satisfaction and optimization problems. Finally, we empirically study the efficiency of our query answering and explanation framework using a benchmark we built upon the well-established LUBM benchmark.

     

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    Übergeordneter Titel: ISSN: 1076-9757 ; Journal of Artificial Intelligence Research ; https://hal.inria.fr/hal-02066288 ; Journal of Artificial Intelligence Research, 2019, 64, pp.563-644. &#x27E8;10.1613/jair.1.11395&#x27E9;
    Schlagworte: [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI]; [INFO.INFO-DB]Computer Science [cs]/Databases [cs.DB]
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  21. Comparison of Anti-Viral Activity of Frog Skin Anti-Microbial Peptides Temporin-Sha and [K3]SHa to LL-37 and Temporin-Tb against Herpes Simplex Virus Type 1

    International audience ; Temporins are anti-microbial peptides synthesized in the skin of frogs of the Ranidae family. The few studies to date that have examined their anti-viral properties have shown that they have potential as anti-viral therapies.... mehr

     

    International audience ; Temporins are anti-microbial peptides synthesized in the skin of frogs of the Ranidae family. The few studies to date that have examined their anti-viral properties have shown that they have potential as anti-viral therapies. In this work, we evaluated the anti-herpes simplex virus type 1 (HSV-1) activity of the temporin-SHa (SHa) and its synthetic analog [K³]SHa. Human cathelicidin LL-37 and temporin-Tb (Tb), previously demonstrated to have anti-HSV-1 properties, were used as positive controls. We observed that SHa and [K³]SHa significantly inhibit HSV-1 replication in human primary keratinocytes when used at micromolar concentrations. This anti-viral activity was equivalent to that of Tb, but lower than that of LL-37. Transcriptomic analyses revealed that SHa did not act through the modulation of the cell innate immune response, but rather, displayed virucidal properties by reducing infectious titer of HSV-1 in suspension. In contrast, pre-incubation of the virus with LL-37 suggests that this peptide does not act directly on the viral particle at non-cytotoxic concentrations tested. The anti-HSV-1 activity of LL-37 appears to be due to the potentiation of cellular anti-viral defenses through the induction of interferon stimulated gene expression in infected primary keratinocytes. This study demonstrated that SHa and [K³]SHa, in addition to their previously reported antibacterial and antiparasitic activities, are direct-acting anti-HSV-1 peptides. Importantly, this study extends the little studied anti-viral attributes of frog temporins and offers perspectives for the development of new anti-HSV-1 therapies.

     

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    Übergeordneter Titel: ISSN: 1999-4915 ; Viruses ; https://hal.sorbonne-universite.fr/hal-02066789 ; Viruses, 2019, 11 (1), pp.77. &#x27E8;10.3390/v11010077&#x27E9;
    Schlagworte: Tb; temporin; SHa; keratinocyte; cytotoxicity; anti-viral; immunomodulation; [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology; [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology
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  22. Epithelial stratification shapes infection dynamics
    Erschienen: 2019
    Verlag:  HAL CCSD ; Public Library of Science

    International audience ; Infections of stratified epithelia contribute to a large group of common diseases, such as dermatological conditions and sexually transmitted diseases. To investigate how epithelial structure affects infection dynamics, we... mehr

     

    International audience ; Infections of stratified epithelia contribute to a large group of common diseases, such as dermatological conditions and sexually transmitted diseases. To investigate how epithelial structure affects infection dynamics, we develop a general ecology-inspired model for stratified epithelia. Our model allows us to simulate infections, explore new hypotheses and estimate parameters that are difficult to measure with tissue cell cultures. We focus on two contrasting pathogens: Chlamydia trachomatis and Human papillomaviruses (HPV). Using cervicovaginal parameter estimates, we find that key infection symptoms can be explained by differential interactions with the layers, while clearance and pathogen burden appear to be bottom-up processes. Cell protective responses to infections (e.g. mucus trapping) generally lowered pathogen load but there were specific effects based on infection strategies. Our modeling approach opens new perspectives for 3D tissue culture experimental systems of infections and, more generally, for developing and testing hypotheses related to infections of stratified epithelia. Author summary Many epithelia are stratified in layers of cells and their infection can result in many pathologies, from rashes to cancer. It is important to understand to what extent the epi-thelial structure determines infection dynamics and outcomes. To aid experimental and clinical studies, we develop a mathematical model that recreates epithelial and infection dynamics. By applying it to a virus, human papillomavirus (HPV), and a bacteria, chla-mydia, we show that considering stratification improves our general understanding of disease patterns. For instance, the duration of infection can be driven by the rate at which the stem cells of the epithelium divide. Having a general model also allows us to investigate and compare hypotheses. This ecological framework can be modified to study specific pathogens or to estimate parameters from data generated in 3D skin cell culture experiments. PLOS ...

     

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  23. Mycobacterium chimaera Pulmonary Disease in Cystic Fibrosis Patients, France, 2010–2017
    Erschienen: 2019
    Verlag:  HAL CCSD ; Centers for Disease Control and Prevention

    International audience mehr

     

    International audience

     

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    Übergeordneter Titel: ISSN: 1080-6040 ; EISSN: 1080-6059 ; Emerging Infectious Diseases ; https://hal.science/hal-02069924 ; Emerging Infectious Diseases, 2019, 25 (3), pp.611-613. &#x27E8;10.3201/eid2503.181590&#x27E9;
    Schlagworte: respiratory infections; tuberculosis and other mycobacteria; France; Mycobacterium avium complex; Mycobacterium chimaera; NTM; bacteria; cystic fibrosis; forced expiratory volume; forced vital capacity; nontuberculosis mycobacteria; pulmonary disease; [SDV]Life Sciences [q-bio]
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  24. Gaia Data Release 2. Variable stars in the colour-absolute magnitude diagram

    International audience ; Context. The ESA Gaia mission provides a unique time-domain survey for more than 1.6 billion sources with G 21 mag. Aims. We showcase stellar variability in the Galactic colour-absolute magnitude diagram (CaMD). We focus on... mehr

     

    International audience ; Context. The ESA Gaia mission provides a unique time-domain survey for more than 1.6 billion sources with G 21 mag. Aims. We showcase stellar variability in the Galactic colour-absolute magnitude diagram (CaMD). We focus on pulsating, eruptive, and cataclysmic variables, as well as on stars that exhibit variability that is due to rotation and eclipses. Methods. We describe the locations of variable star classes, variable object fractions, and typical variability amplitudes throughout the CaMD and show how variability-related changes in colour and brightness induce "motions". To do this, we use 22 months of calibrated photometric, spectro-photometric, and astrometric Gaia data of stars with a significant parallax. To ensure that a large variety of variable star classes populate the CaMD, we crossmatched Gaia sources with known variable stars. We also used the statistics and variability detection modules of the Gaia variability pipeline. Corrections for interstellar extinction are not implemented in this article. Results. Gaia enables the first investigation of Galactic variable star populations in the CaMD on a similar, if not larger, scale as was previously done in the Magellanic Clouds. Although the observed colours are not corrected for reddening, distinct regions are visible in which variable stars occur. We determine variable star fractions to within the current detection thresholds of Gaia. Finally, we report the most complete description of variability-induced motion within the CaMD to date. Conclusions. Gaia enables novel insights into variability phenomena for an unprecedented number of stars, which will benefit the understanding of stellar astrophysics. The CaMD of Galactic variable stars provides crucial information on physical origins of variability in a way that has previously only been accessible for Galactic star clusters or external galaxies. Future Gaia data releases will enable significant improvements over this preview by providing longer time series, more accurate ...

     

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    Übergeordneter Titel: ISSN: 0004-6361 ; EISSN: 1432-0756 ; Astronomy and Astrophysics - A&A ; https://hal.science/hal-02071443 ; Astronomy and Astrophysics - A&A, 2019, 623, pp.A110. &#x27E8;10.1051/0004-6361/201833304&#x27E9;
    Schlagworte: [SDU.ASTR.GA]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Galactic Astrophysics [astro-ph.GA]; [SDU.ASTR.SR]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Solar and Stellar Astrophysics [astro-ph.SR]; [PHYS]Physics [physics]; [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
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  25. Selective sulfoxidation reactions with H2O2 catalyzed by Ti-containing SBA-15 materials
    Erschienen: 2019
    Verlag:  HAL CCSD ; Springer Verlag

    International audience ; This contribution relates the behavior of Ti-SBA-15 catalysts in the sulfoxidation reaction with hydrogen peroxide under mild conditions (40–70 °C). Ti-SBA-15 samples with 1, 3 and 5 wt% of TiO2 have been prepared by grafting... mehr

     

    International audience ; This contribution relates the behavior of Ti-SBA-15 catalysts in the sulfoxidation reaction with hydrogen peroxide under mild conditions (40–70 °C). Ti-SBA-15 samples with 1, 3 and 5 wt% of TiO2 have been prepared by grafting SBA-15 silica with Ti(OiPr)4 in ethanol followed by calcination. Due to their mesopores, the Ti-containing catalysts accommodated large molecules like methyl-phenyl-sulfide, diphenylsulfide and dibenzothiophene, which were selectively oxidized into their corresponding sulfoxides and sulfones. The turnover frequency was correlated with the amount of the tetrahedral Ti atoms in the catalyst. During the oxidation process performed in batch mode, with acetonitrile or ethanol as solvent, the catalyst topology and texture were preserved, but the nature of the Ti species suffered some changes.

     

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    Übergeordneter Titel: ISSN: 1380-2224 ; EISSN: 1573-4854 ; Journal of Porous Materials ; https://hal.science/hal-02073786 ; Journal of Porous Materials, 2019, 26 (2), pp.533-539. &#x27E8;10.1007/s10934-018-0640-1&#x27E9;
    Schlagworte: sulfoxidation; heterogeneous catalysis; [CHIM]Chemical Sciences; [CHIM.CATA]Chemical Sciences/Catalysis