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Bu çalışmada, böbrek bozukluklarının böbrek üstü bezlerinde herhangi bir değişikliğe yol açıp açmadığı incelenmiştir. Araştırma,120 baş erkek Merinos kuzu ve 30 baş erkek sığırdan alınan, toplam 15U çift böbrek ve böbrek üstü bezi üzerinde yapılmiştır. Kuzu materyali 87/15 no'lu projeden sağlanmıştır.bu projede, konsantre yemlemeye tabi tutulan kuzularda böbrek taşı oluşması ve bu oluşumun önlenmesi için, l/i- tahmin-A, ya da alkali su içirmekle önleme yöntemleri, tek bağışına veya beraberce uygulanmıştır. Sığır materyali ise, U.Ü. Veteriner Fakültesi besi ünitesi hayvanları ile, Bursa Et ve Balık Kurumu'nda kesilen, kasaplık besi hayvanlarından elde edilmiştir. Toplanan böbrekler (15ü olay), histopatolojik olarak incelendikten sonra, lezyonlara güre 4 gruba ayrılmıştır. 1 . grup,histopatolojik muayenede sağlam olduğu saptanan kontrol grubu (31 olay) Diup, hastalarla karşılaştırılmada kullanılmıştır .Lezyon görülenler ise sırasıyla, hafif (35 olay), orta (4 7 alay) ve ileri derecede hasarlı böbrekler (37 olay) alarak sınıflandırılmıştır. Bütün bu böbreklere ait adrenal bezler de, ışıklı mikroskopta incelenmiş ve bu incelemede, böbrek üstü bezle¬rinin, böbreklerdeki bozukluklarla paralel seyreden ve istatistik önemi büyük olan,çeşitli değişiklikler gösterdikleri saptanmıştır. Bu değişiklikler: Stromal bay dokunun genel artışı ( % 25.k, P<0.00 ve burada oluşan metaplazik değişmeler (Normal grupta % 3.2 hastalarda % 16.1) - Medullada hayalinize olmuş hücrelerin görülmesi (% 17.0, P<0.01) -Kortex'te yığınlar halinde degrenüle hücrelerin varlığı ( % 12.0, P<0.01) -Z. glomerulose hücrelerinde değişen derecelerde atrofi ve bu katda vasküler genişlemeler (normal grupta % 3.2, hasta gruplarda ise % 11.4, % 38.3, % 46.0, P<0.001) -Z. glomerulose'nin hiperplazisi ( % 15.0, P<0.01) ile diğer kortex katlarının hiperplazisi (Normal grupta % 12.9, hastalarda % 74.0, P<0.01) -Medülle ve kortex'te adenoid yapılar şeklindeki kortex adacıları oluşumu (normal grupta % 9.7, hastalarda % 52.0, % 38.3, % 46.0, P<0.001) dur. Bu sonuçlar, böbreklerde keşif veya dengesiz besleme sonu oluşup zamanla artan yıkımla doğru orantılı olarak ilerleyen böbrek fonksiyon kayıplarının böbrek üstü bezlerinde de birçok hücresel ve fonksiyonel bozukluklara neden olduğunu göstermiştir. ; The aim of this study was to examine the possible effects of renal disorders on the adrenal glands of sheep and cattle kept on fattening diets. The study material that included kidneys and adrenal glands in pairs, was obtained from 120 heads of male merino lambs and 3U heads Qf cattle of mixed breeds. The kidneys and adrenals obtained from lambs that were also used as the material for the project Q7/15 which was supported and financed by the Uludağ University Research fund, and aimed to study the preventive effect of alkalinizatian of drinking water supply and vitamin-A coadministration on the farmati- on of urinary calculi in fattening sheep. Bovine material was collected in Et ve Balık Kurumu'a slaughter house in Bursa. The kidneys were divided into four groups fallowing the histologic examinations according to their pathology. The first group, consisted of 31 heads of lambs* material only that did not exhibit any pathologic lesion and was used the negative controls to compare the rest of diseased kidneys, since the cattle material were all at least dama¬ged in part of ranal failure due to the ageing of animals. The diseased kidneys of second group were classified as the least damaged cases and totaled up to 35 heads (cattle 5 and lambs 30).The third group included moderately damaged i+? pairs of kidneys (cattle 9, lambs 38), and the last grout was consisted of 37 cases (cattle 16, lambs 21) and were the heavily damaged kidneys. Similarly the adrenal glands belonging the same animals were also examined under the light microscopy and the pathological findings which were statistically very important changes and were in a strict correlation with the seve¬rity of renal damage were summarized as follows: a) A general increase in the amount of stromal connective tissue ( 25.*+ %, R^TD.001), and metaplastic changes in it ( 16.1 % vs 3.2 % in normal aged animals). b) Hyalinized cells in the medullary portion of the gland of animals with diseased kidneys ( 17.0 %, P^Q.DQD. c) Clumps of degranulated cells.in the adrenal cortex that were most heavily seen in the Z.fasciculata ( 12.0 %, P<^Q .001) . d) Atrophia and sinusoidal enlargements in the Z. glomerulosa that was increasingly severe according to the renal damage ( 11.*+ %, 38.3 % and ¿+6.0 % respectively, P^O.QDD that compares with the atrophia and vascular damage due to senility seen in old cattle (3.2 % ). e) Hyperplasia of Z.glomerulosa ( 15.0 %, P<0.001) and other cortical layers ( 12.9 % in old animals and 7*+.0 % in diseased animals PsgU.QQI). f) Adenoid structures of cortical origin that appeared in the cortex and in the medullary portion of the gland ( 9.7 % in normal kidney bearing animals and 52.0 % in diseased animals P^D.001). According to these findings, the renal damage that occurred as the result of concentrated feeds or imbalanced diets, also causes the damage with the same severity in the adrenal gland of the subject animals. ; Beschadigungen der Nebennierendrüsen bezüglich mit nieren filtern problemen. Der Zueck dieser uissenschaftlichen Untersuchung waj zu Klaren, Uelche eventuellen bJirkungen bei Nieren Störunger a uf di e Nebennierendrüsen bei Schafen und Rindern hinsicht-lich Biner fetthaltigen Diöt Uerpflegung entstehen. Das Studien Material uurde gelie fert aus Nieren und Nebennierendrüsen von 12D Merino-Schafen und 30 Rindern ge-mischter Hassen. Die von den Shafen erhaltenden Nieren und Nebennierendrüsen uurden ausserdem al s Studien-Material zum Projekt Ö7/15 veruendet.Dieses Projekt uurde unterstützt um finanziert vom Untersuchungsfond der Uludağ Universitât. Be: diesem Projekt uar zu untersuchen uie alkalinisiertes LJasse: und Uitamin-A-Zugaben eine Nierenstein-Formation bei SchlacI tschafen zu verhindern sind. Das Rinder material uurde ge-sammelt im Et ve Balık Kurumu des Schlachthausea in Bursa. Nach histalogisher Untersuchung uurden die Nieren entsprechend ihrer Patologie in vier Gruppen eingeteilt. Die erste Gruppe, bestehend aus 31 Stück Schafen,zeigten Keine Patologischen Uerânderungen und uurden benutzt zum Vergleich der übrigen erKrankten Nieren. Das gesamte Rinder materal uar beschödigt in verschiedenen Graden bezu. abhöngig von Alter der Tiere. Die erKrankten Nieren der Zueiten Gruppe uurden Klassifiziert in mindest beschâdigte Faile; insgesamt uaren es 35 Stück (Rinde 5 und Schafe 30). Die dritte Gruppe enthielt mittelmössig beschâdigte Nieren (A7 Paar Nieren, und zuar 9 Rinder und 38 Schafs nieren), und die Letzte Gruppe von schujerst geschSdigten Nieren üesta aus 37 Fallen (16 Rinder, 21 Schafe). Die Nebennierendrüsen der gleicher Tiere uurden eben falls durch das Licht-Mikroskop untersucht. Die patologisc-hen Befunde sind statistisch sehr michtig und ueisen bedeuten de Anderungen bezüglich ernsthafter Nierenbeschadigungen auf Diese Befunde sind nachstehend im Hurzer Form angegeben: a) Allgemeines Uermehren der Menge de s Bindegeuıebes ( 25.A %, P<0.□1), und Metaplasticshe Ueranderungen dessel-ben ( 16.1 % in kranken, 3.2 % in normalen Tieren). b ) Hyalinische Ze1len in der Medülla der Drüsen von Tieren mit Kranka Nieren ( 17.0 %, PcO.ÛOD. c ) Entgranulierte Zellenklümpen in Nebennierendrüsen Kur t ex, die meistens im Z.fasciculata zu sehen uıaren ( 12.0 %. R^O.001). d) Atrophie und Sinusoidalische Eruıeiterungen im Z. glomerulosa, die sich immermehr steigern nach der Beschâdi-gung der Nieren ( 11.A % , 33.3 % und 46.0 % beziehungsuıeise P D.00İ), es hölt den Vergleich mit Atrophie und Gefössbesc-hödigungen abh8ngig von der Senilitât alter Rinder ( 3.D %). e) Hyperplasie im Z .glomerulosa ( 15.0 %, P^O.001) und in den anderen Kortex Schichten ( 12.9 % in alten Tieren und 74.0 % in kranken Tieren, P^ü.001). f) Adenoid Gefüge von KortiKalischen Ursprunga die erscheinen im Kortex und Medülla der drüsen (9.7 % bei Tieren mit normalen Nieren und 52.0 % bei kranken Tieren, P^O.001). Das Ergebnis dieaer Untersuchung: Nierenbeschödigun-gen, die durch eine Fetthaltige öder unausgeglichene Verpf-legung hervorgerufen uurden, geben Anlass zu Beschâdigungen verschiedenen AUsmasse der Nebennierendrüsen.
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