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  1. Associations of liver dysfunction with glucose intolerance and all-cause mortality in a general population
    Autor*in: Naeem, Muhammad
    Erschienen: 2022

    hepatic markers, MRI, General populations Liver dysfunctions are commonly associated with diabetes and mortality in the general population. However, previous studies lack to define these disorders with hepatic markers from MRI, which have been shown... mehr

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    Universitätsbibliothek Greifswald
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    hepatic markers, MRI, General populations Liver dysfunctions are commonly associated with diabetes and mortality in the general population. However, previous studies lack to define these disorders with hepatic markers from MRI, which have been shown to be more accurate and sensitive than hepatic ultrasound and laboratory markers. Further, previous studies defining different categories of prediabetes by oral glucose tolerance states revealed controversial findings. Hence, this dissertation contributed to understand the associations of liver dysfunctions with glucose intolerance states and all-cause mortality in the general population. In the first part of the dissertation, the associations of MRI-related hepatic steatosis and hepatic iron overload with prediabetes were investigated. Prediabetes was categorized into IFG, IGT, (alone or in combination) or previously unknown type 2 diabetes mellitus using OGGT data, as suggested by the ADA. For analyses, we included 1632 subjects with MRI who participated in an OGTT and reported no type 2 diabetes mellitus. We found that hepatic steatosis was positively associated with continuous markers of glucose metabolism. Similarly, subjects with hepatic steatosis as defined by MRI had a higher relative risk ratio to be in the prediabetes groups (i-IFG, i-IGT and IFG + IGT) or having undiagnosed diabetes than individuals without this condition. The observed associations were more obvious for MRI-derived hepatic steatosis compared to ultrasound. In comparison to hepatic steatosis, ...

     

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    Quelle: Verbundkataloge
    Beteiligt: Völzke, Henry (AkademischeR BetreuerIn); Aghdassi, Ali (AkademischeR BetreuerIn); Ittermann, Till (AkademischeR BetreuerIn)
    Sprache: Englisch
    Medientyp: Dissertation
    Format: Online
    Weitere Identifier:
    Schlagworte: Leber; Funktionsstörung; Glucose; Intoleranz <Motiv>; Sterblichkeit; Marker; Kernspintomografie;
    Umfang: 1 Online-Ressource (PDF-Datei: 61 Seiten, 2770 Kilobyte), Diagramme (farbig)
    Bemerkung(en):

    Literaturverzeichnis: Seite 17-21. - Literaturangaben

    Dissertation, Universitätsmedizin der Universität Greifswald, 2023

  2. Associations of liver dysfunction with glucose intolerance and all-cause mortality in a general population
    Autor*in: Naeem, Muhammad
    Erschienen: 2022

    Universitätsbibliothek Greifswald
    509/10399
    keine Fernleihe
    Universitätsbibliothek Greifswald
    509/10400
    uneingeschränkte Fernleihe, Kopie und Ausleihe
    Export in Literaturverwaltung   RIS-Format
      BibTeX-Format
    Quelle: Verbundkataloge
    Beteiligt: Völzke, Henry (AkademischeR BetreuerIn); Aghdassi, Ali (AkademischeR BetreuerIn); Ittermann, Till (AkademischeR BetreuerIn)
    Sprache: Englisch
    Medientyp: Dissertation
    Format: Druck
    Schlagworte: Leber; Funktionsstörung; Glucose; Intoleranz <Motiv>; Sterblichkeit; Marker; Kernspintomografie;
    Umfang: vi, 55 Seiten, Diagramme
    Bemerkung(en):

    Literaturverzeichnis: Seite 17-21. - Literaturangaben

    Dissertation, Universitätsmedizin der Universität Greifswald, 2023