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  1. Neuregulin1/ErbB4-induced migration in ST14A striatal progenitors: calcium-dependent mechanisms and modulation by NMDA receptor activation
    Autor*in: PREGNO, GIULIA; ZAMBURLIN, Pollyanna; GAMBAROTTA, Giovanna; FARCITO, SILVIA; FREGNAN, Federica; PERROTEAU, Isabelle; LOVISOLO, Davide; BOVOLIN, Patrizia; Licheri V
    Erschienen: 2011

    Background: A number of studies have separately shown that the neuregulin1 (NRG1)/ErbB4 system and NMDAtype glutamate receptors (NMDARs) are involved in several aspects of neuronal migration. In addition, intracellular calcium fluctuations play... mehr

     

    Background: A number of studies have separately shown that the neuregulin1 (NRG1)/ErbB4 system and NMDAtype glutamate receptors (NMDARs) are involved in several aspects of neuronal migration. In addition, intracellular calcium fluctuations play central roles in neuronal motility. Stable expression of the tyrosine kinase receptor ErbB4 promotes migratory activity in the neural progenitor cell line ST14A upon NRG1 stimulation. In this work we analyzed the potential interactions between the NRG1/ErbB4 system and NMDARs in the ST14A migratory process as well as its calcium dependence. Results: RT-PCR studies have shown that both native ST14A cells (non-expressing ErbB4), as well as ErbB4- transfected cells express low levels of a restricted number of NMDAR subunits: NR1, NR2C, NR2D and NR3B. The resulting NMDAR would form Ca2+ channels characterized by low Mg2+-sensitivity and low Ca2+-permeability, generating small, long-lasting currents. Ca2+-imaging experiments showed slow [Ca2+]i increases in 45% of the cells following 8 μM NMDA stimulation. Basal migration of ErbB4-transfected ST14A cells was unaffected by 18 hrs NMDA incubation. However, over the same incubation time, NMDA was able to significantly enhance NRG1- induced migration. Pre-incubation with the intracellular calcium chelator BAPTA-AM reduced both NRG1- and NRG1/NMDA-stimulated migration, suggesting the involvement of Ca2+ in these processes. NRG1 stimulation of ErbB4-transfected ST14A cells induced a sustained, long-lasting increase in [Ca2+]i, in 99% of the cells. These intracellular Ca2+ signals could be ascribed to both release from intracellular stores and influx from the extracellular medium trough a mechanism of store-operated calcium entry (SOCE). Short-time co-incubation of NMDA and NRG1 did not substantially modify the NRG1-induced intracellular calcium signals. Conclusions: In summary, NRG1 stimulation of the ErbB4 receptor exerts a sustained [Ca2+]i increase in ST14A neural progenitors; NRG1-induced migration is Ca2+-dependent and can be ...

     
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    Quelle: BASE Fachausschnitt AVL
    Sprache: Englisch
    Medientyp: Aufsatz aus einer Zeitschrift
    Format: Online
    Schlagworte: migration; neuregulin; NMDA receptor; neural progenitor; calcium imaging; SOCE; thapsigargin; schizophrenia
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    info:eu-repo/semantics/openAccess
  2. How much schizophrenia do famines cause?
    Autor*in: Ó Gráda, Cormac; Li, Chihua; Lumey, L. H.
    Erschienen: 2023
    Verlag:  UCD School of Economics, University College Dublin, Dublin

    Since the 1970s, famines have been widely invoked as natural experiments in research into the long-term impact of foetal exposure to nutritional shocks. That research has produced compelling evidence for a robust link between foetal exposure and the... mehr

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    DS 120
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    Since the 1970s, famines have been widely invoked as natural experiments in research into the long-term impact of foetal exposure to nutritional shocks. That research has produced compelling evidence for a robust link between foetal exposure and the odds of developing schizophrenia. However, the implications of that research for the human cost of famines in the longer run has not been investigated. We address the connection between foetal origins and schizophrenia with that question in mind. The impact turns out to be very modest - much less than one per cent of the associated famine death tolls - across a selection of case studies.

     
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    Quelle: Verbundkataloge
    Sprache: Englisch
    Medientyp: Buch (Monographie)
    Format: Online
    Schriftenreihe: Working paper series / UCD Centre for Economic Research ; WP23, 28 (December 2023)
    Schlagworte: famine; schizophrenia; foetal origins
    Umfang: 1 Online-Ressource (circa 22 Seiten)