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  1. Pharmacy-based interdisciplinary intervention for patients with chronic heart failure: results of the PHARM-CHF randomized controlled trial
    Autor*in: Schulz, Martin; Griese-Mammen, Nina; Anker, Stefan; Köhler, Friedrich; Ihle, Peter; Ruckes, Christian; Schumacher, Pia Madeleine; Trenk, Dietmar; Böhm, Michael; Laufs, Ulrich
    Erschienen: 2023
    Verlag:  Universität, Freiburg

    Abstract: Aims<br>Medication non-adherence is frequent and is associated with high morbidity and mortality in patients with chronic heart failure (CHF). We investigated whether an interdisciplinary intervention improves adherence in elderly CHF... mehr

     

    Abstract: Aims
    Medication non-adherence is frequent and is associated with high morbidity and mortality in patients with chronic heart failure (CHF). We investigated whether an interdisciplinary intervention improves adherence in elderly CHF patients.

    Methods and results
    The study population (mean age 74 years, 62% male, mean left ventricular ejection fraction 47%, 52% in New York Heart Association class III) consisted of 110 patients randomized into the pharmacy care and 127 into the usual care group. The median follow-up was 2.0 years (interquartile range 1.2–2.7). The pharmacy care group received a medication review followed by regular dose dispensing and counselling. Control patients received usual care. The primary endpoint was medication adherence as proportion of days covered (PDC) within 365 days for three classes of heart failure medications (beta-blockers, angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, and mineralocorticoid receptor antagonists). The main secondary outcome was the proportion of adherent patients (PDC ≥ 80%). The primary safety endpoint was days lost due to unplanned cardiovascular hospitalizations (blindly adjudicated) or death. Pharmacy care compared with usual care resulted in an absolute increase in mean adherence to three heart failure medications for 365 days [adjusted difference 5.7%, 95% confidence interval (CI) 1.6–9.8, P = 0.007]. The proportion of patients classified as adherent increased (odds ratio 2.9, 95% CI 1.4–5.9, P = 0.005). Pharmacy care improved quality of life after 2 years (adjusted difference in Minnesota Living with Heart Failure Questionnaire scores −7.8 points (−14.5 to −1.1; P = 0.02), compared to usual care. Pharmacy care did not affect the safety endpoints of hospitalizations or deaths.

    Conclusion
    Pharmacy care safely improved adherence to heart failure medications and quality of life

     
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    Quelle: Verbundkataloge
    Sprache: Englisch
    Medientyp: Buch (Monographie)
    Format: Online
    Weitere Identifier:
    Schlagworte: Chronische Herzinsuffizienz; Apotheke; Dienst; Arzneimittel; Betreuung; Interdisziplinarität; Studie; Randomisierung
    Weitere Schlagworte: Chronic heart failure; Community pharmacy services; Medication adherence; Interdisciplinary care; Randomized controlled trial; Pharmacy care; (local)article
    Umfang: Online-Ressource
    Bemerkung(en):

    European journal of heart failure. - 21, 8 (2019) , 1012-1021, ISSN: 1879-0844
  2. Pharmacy-based interdisciplinary intervention for patients with chronic heart failure: results of the PHARM-CHF randomized controlled trial
    Autor*in: Schulz, Martin; Griese-Mammen, Nina; Anker, Stefan; Köhler, Friedrich; Ihle, Peter; Ruckes, Christian; Schumacher, Pia Madeleine; Trenk, Dietmar; Böhm, Michael; Laufs, Ulrich
    Erschienen: 2023
    Verlag:  Universität, Freiburg

    Abstract: Aims<br>Medication non-adherence is frequent and is associated with high morbidity and mortality in patients with chronic heart failure (CHF). We investigated whether an interdisciplinary intervention improves adherence in elderly CHF... mehr

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    Technische Hochschule Bingen, Bibliothek
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    Bibliothek der Hochschule Darmstadt, Zentralbibliothek
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    TU Darmstadt, Universitäts- und Landesbibliothek - Stadtmitte
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    Bibliothek der Frankfurt University of Applied Sciences
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    Universitätsbibliothek J. C. Senckenberg, Zentralbibliothek (ZB)
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    Hochschul- und Landesbibliothek Fulda, Standort Heinrich-von-Bibra-Platz
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    Technische Hochschule Mittelhessen, Hochschulbibliothek Gießen
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    Universitätsbibliothek Gießen
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    Universitätsbibliothek Kassel, Landesbibliothek und Murhardsche Bibliothek der Stadt Kassel
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    Universität Mainz, Zentralbibliothek
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    Universität Marburg, Universitätsbibliothek
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    Hochschul- und Landesbibliothek RheinMain, Rheinstraße
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    Abstract: Aims
    Medication non-adherence is frequent and is associated with high morbidity and mortality in patients with chronic heart failure (CHF). We investigated whether an interdisciplinary intervention improves adherence in elderly CHF patients.

    Methods and results
    The study population (mean age 74 years, 62% male, mean left ventricular ejection fraction 47%, 52% in New York Heart Association class III) consisted of 110 patients randomized into the pharmacy care and 127 into the usual care group. The median follow-up was 2.0 years (interquartile range 1.2–2.7). The pharmacy care group received a medication review followed by regular dose dispensing and counselling. Control patients received usual care. The primary endpoint was medication adherence as proportion of days covered (PDC) within 365 days for three classes of heart failure medications (beta-blockers, angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, and mineralocorticoid receptor antagonists). The main secondary outcome was the proportion of adherent patients (PDC ≥ 80%). The primary safety endpoint was days lost due to unplanned cardiovascular hospitalizations (blindly adjudicated) or death. Pharmacy care compared with usual care resulted in an absolute increase in mean adherence to three heart failure medications for 365 days [adjusted difference 5.7%, 95% confidence interval (CI) 1.6–9.8, P = 0.007]. The proportion of patients classified as adherent increased (odds ratio 2.9, 95% CI 1.4–5.9, P = 0.005). Pharmacy care improved quality of life after 2 years (adjusted difference in Minnesota Living with Heart Failure Questionnaire scores −7.8 points (−14.5 to −1.1; P = 0.02), compared to usual care. Pharmacy care did not affect the safety endpoints of hospitalizations or deaths.

    Conclusion
    Pharmacy care safely improved adherence to heart failure medications and quality of life

     
    Export in Literaturverwaltung   RIS-Format
      BibTeX-Format
    Quelle: Verbundkataloge
    Sprache: Englisch
    Medientyp: Buch (Monographie)
    Format: Online
    Weitere Identifier:
    DDC Klassifikation: Medizin und Gesundheit (610)
    Schlagworte: Chronische Herzinsuffizienz; Apotheke; Dienst; Arzneimittel; Betreuung; Interdisziplinarität; Studie; Randomisierung
    Umfang: 1 Online-Ressource
    Bemerkung(en):

    European journal of heart failure. - 21, 8 (2019) , 1012-1021, ISSN: 1879-0844