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  1. Verantwortungsvoller Einsatz von KI?
    Mit menschlicher Kompetenz!
    Autor*in: Ammon, Sabine; Dössel, Olaf; Hermann, Isabella; Markschies, Christoph Johannes; Molnár-Gábor, Fruzsina; Nida-Rümelin, Julian; Peters, Jonas; Pflüger, Dirk; Rademacher, Timo; Renn, Ortwin; Rostalski, Frauke; Schweizer, Pia-Johanna; Stock, Günter; Thiel, Thorsten
    Erschienen: 2021
    Verlag:  Berlin-Brandenburgische Akademie der Wissenschaften, Berlin

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    Standort:
    Universitätsbibliothek Erfurt / Forschungsbibliothek Gotha, Universitätsbibliothek Erfurt
    Fernleihe:
    keine Fernleihe

    Standort:
    ZBW - Leibniz-Informationszentrum Wirtschaft, Standort Kiel
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    Export in Literaturverwaltung   RIS-Format
      BibTeX-Format
    Quelle: Verbundkataloge
    Sprache: Deutsch
    Medientyp: Buch (Monographie)
    Format: Online
    Weitere Identifier:
    Schriftenreihe: #VerantwortungKI - Künstliche Intelligenz und gesellschaftliche Folgen ; 4 (2021)
    Schlagworte: Demokratiefolgen; Europäische Union; menschliche Kompetenz
    Umfang: 1 Online-Ressource (68 Seiten), Illustrationen
  2. Modeling selective therapeutic hypothermia in case of acute ischemic stroke using a 1D hemodynamics model and a simplified brain geometry
    Autor*in: Lutz, Yannick; Daschner, Rosa; Krames, Lorena; Loewe, Axel; Cattaneo, Giorgio Franco Maria; Meckel, Stephan; Dössel, Olaf
    Erschienen: 2020
    Verlag:  Universität, Freiburg

    Abstract: Therapeutic hypothermia (TH) is an approved neuroproctetive treatment to reduce neurological morbidity and mortality after hypoxic-ischemic damage related to cardiac arrest and neonatal asphyxia. Also in the treatment of acute ischemic... mehr

     

    Abstract: Therapeutic hypothermia (TH) is an approved neuroproctetive treatment to reduce neurological morbidity and mortality after hypoxic-ischemic damage related to cardiac arrest and neonatal asphyxia. Also in the treatment of acute ischemic stroke (AIS), which in Western countries still shows a very high mortality rate of about 25 %, selective mild TH by means of Targeted Temperature Management (TTM) could potentially decrease final infarct volume. In this respect, a novel intracarotid blood cooling catheter system has recently been developed, which allows for combined carotid blood cooling and mechanical thrombectomy (MT) and aims at selective mild TH in the affected ischemic brain (core and penumbra). Unfortunately, so far direct measurement and control of cooled cerebral temperature requires invasive or elaborate MRI-assisted measurements. Computational modeling provides unique opportunities to predict the resulting cerebral temperatures on the other hand. In this work, a simplified 3D brain model was generated and coupled with a 1D hemodynamics model to predict spatio-temporal cerebral temperature profiles using finite element modeling. Cerebral blood and tissue temperatures as well as the systemic temperature were analyzed for physiological conditions as well as for a middle cerebral artery (MCA) M1 occlusion. Furthermore, vessel recanalization and its effect on cerebral temperature was analyzed. The results show a significant influence of collateral flow on the cooling effect and are in accordance with experimental data in animals. Our model predicted a possible neuroprotective temperature decrease of 2.5 ℃ for the territory of MCA perfusion after 60 min of blood cooling, which underlines the potential of the new device and the use of TTM in case of AIS

     
    Export in Literaturverwaltung   RIS-Format
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    Quelle: Verbundkataloge
    Sprache: Englisch
    Medientyp: Buch (Monographie)
    Format: Online
    Weitere Identifier:
    Schlagworte: Anastomose; Hypothermie; Hypothermie
    Weitere Schlagworte: Acute ischemic stroke; Ttargeted temperature management; Therapeutic hypothermia; Finite element modeling; Collateral circulation; (local)article
    Umfang: Online-Ressource
    Bemerkung(en):

    Mathematical biosciences and engineering. - 17, 2 (2020) , 1147-1167, ISSN: 1551-0018
  3. Modeling selective therapeutic hypothermia in case of acute ischemic stroke using a 1D hemodynamics model and a simplified brain geometry
    Autor*in: Lutz, Yannick; Daschner, Rosa; Krames, Lorena; Loewe, Axel; Cattaneo, Giorgio Franco Maria; Meckel, Stephan; Dössel, Olaf
    Erschienen: 2020

    Abstract: Therapeutic hypothermia (TH) is an approved neuroproctetive treatment to reduce neurological morbidity and mortality after hypoxic-ischemic damage related to cardiac arrest and neonatal asphyxia. Also in the treatment of acute ischemic... mehr

     

    Abstract: Therapeutic hypothermia (TH) is an approved neuroproctetive treatment to reduce neurological morbidity and mortality after hypoxic-ischemic damage related to cardiac arrest and neonatal asphyxia. Also in the treatment of acute ischemic stroke (AIS), which in Western countries still shows a very high mortality rate of about 25 %, selective mild TH by means of Targeted Temperature Management (TTM) could potentially decrease final infarct volume. In this respect, a novel intracarotid blood cooling catheter system has recently been developed, which allows for combined carotid blood cooling and mechanical thrombectomy (MT) and aims at selective mild TH in the affected ischemic brain (core and penumbra). Unfortunately, so far direct measurement and control of cooled cerebral temperature requires invasive or elaborate MRI-assisted measurements. Computational modeling provides unique opportunities to predict the resulting cerebral temperatures on the other hand. In this work, a simplified 3D brain model was generated and coupled with a 1D hemodynamics model to predict spatio-temporal cerebral temperature profiles using finite element modeling. Cerebral blood and tissue temperatures as well as the systemic temperature were analyzed for physiological conditions as well as for a middle cerebral artery (MCA) M1 occlusion. Furthermore, vessel recanalization and its effect on cerebral temperature was analyzed. The results show a significant influence of collateral flow on the cooling effect and are in accordance with experimental data in animals. Our model predicted a possible neuroprotective temperature decrease of 2.5 ℃ for the territory of MCA perfusion after 60 min of blood cooling, which underlines the potential of the new device and the use of TTM in case of AIS

     
    Export in Literaturverwaltung
    Quelle: BASE Fachausschnitt AVL
    Sprache: Englisch
    Medientyp: Unbestimmt
    Format: Online
    DDC Klassifikation: Englische, altenglische Literaturen (820)
    Schlagworte: Acute ischemic stroke; Ttargeted temperature management; Therapeutic hypothermia; Finite element modeling; Collateral circulation; article
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