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Displaying results 226 to 250 of 760.

  1. Clinical and biological significance of CD157 in ovarian carcinoma
    Author: ORTOLAN, Erika; LO BUONO, NICOLA; MORONE, SIMONA; PARROTTA, ROSSELLA; RAPA, IDA; FERRERO, Enza; VOLANTE, Marco; FUNARO, Ada; R. Arisio; D. Katsaros
    Published: 2011

    Ovarian cancer is one of the most common and lethal gynaecological malignancies. The poor prognosis of ovarian cancer is due to the difficulty of early diagnosis, and the lack of effective therapies for advanced-stage disease. Hence, there is a need... more

     

    Ovarian cancer is one of the most common and lethal gynaecological malignancies. The poor prognosis of ovarian cancer is due to the difficulty of early diagnosis, and the lack of effective therapies for advanced-stage disease. Hence, there is a need for new therapeutic targets and for better understanding of the molecular mechanisms underpinning ovarian cancer cell invasion and dissemination. CD157 (BST-1) is a cell surface NADase/ADP-ribosyl cyclase that mediates leukocyte adhesion to extracellular matrix proteins and diapedesis at site of inflammation. We demonstrated that CD157 is expressed in epithelial ovarian cancer primary cell cultures and tissues, and it is involved in interactions among tumor cells, extracellular matrix proteins, and mesothelium which ultimately control tumor cell migration and invasion. Using stable CD157-overexpression and -knockdown in the ovarian cancer cells lines NIH:OVCAR-3 and OV-90 as model systems, we demonstrated that CD157 promotes morphological and functional changes characterized by i) enhanced matrix metalloproteinases secretion, ii) reduced intercellular cohesion and iii) increased cell motility and invasiveness driven by a mechanism involving the MAPK and PI3K/Akt pathways. The analysis of gene expression profile highlighted 402 unique genes differentially expressed in CD157-positive vs CD157-negative tumor cells (223 up-regulated and 179 down-regulated). Remarkably, functional grouping and ontological analyses revealed that a large proportion of these genes were related to developmental/differentiation processes (including epithelial-to mesenchymal transition); cell-adhesion, migration and cell projection organization; and cell death and apoptosis. At molecular level, CD157 expression induced an E- to N-cadherin switch and an over-expression of EpCAM and CD24, generating cells with combined features of mesenchymal and cancer stem-like cells. Collectively, these data suggest a novel CD157-regulated pathway that could confer an aggressive, mesenchymal/stem cell-like ...

     
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    Subjects: ovarian carcinoma; tumor progression; ectoenzyme
  2. CD157 expression enhances invasiveness of ovarian cancer cells and induces a mesenchymal phenotype
    Author: LO BUONO, NICOLA; BOVINO, PAOLA; MORONE, SIMONA; PARROTTA, ROSSELLA; FERRERO, Enza; MALAVASI, Fabio; FUNARO, Ada; ORTOLAN, Erika; M. Scianna; C. Giverso; L. Preziosi
    Published: 2011

    CD157 is a member of the nicotinamide adenine dinucleotide glycohydrolase (NADase)/adenosine diphosphate (ADP)-ribosyl cyclase gene family implicated in the control of myeloid cell adhesion, migration and diapedesis. Human CD157 is expressed by ~90 %... more

     

    CD157 is a member of the nicotinamide adenine dinucleotide glycohydrolase (NADase)/adenosine diphosphate (ADP)-ribosyl cyclase gene family implicated in the control of myeloid cell adhesion, migration and diapedesis. Human CD157 is expressed by ~90 % of epithelial ovarian cancers and is a powerful independent predictive factor for disease recurrence and survival. We assessed the relevance of CD157 to migration and dissemination of ovarian cancer cells by transfecting the full-length cDNA in the poorly invasive, CD157-negative NIH:OVCAR-3 cell line. The results indicated that CD157 expression in NIH:OVCAR-3 cells is accompanied by marked morphological changes and enhanced spreading of cells. Moreover, CD157 expression reduces cell-cell aggregation and induces reorganization of the actin cytoskeleton thus promoting cell motility and invasiveness. Western blot analysis showed that CD157-positive cells are characterized by a significant decrease in E-cadherin and β-catenin expression compared to CD157-negative control cells. Taken together, these observations indicated that exogenous expression of CD157 is associated with the acquisition of morphological and molecular features of the mesenchymal-like phenotype. This was supported by the results of functional assays showing that CD157-positive NIH:OVCAR-3 cells are characterized by enhanced secretion of matrix metalloproteinase 2, 7 and 9, leading to an increased ability of tumor cells to remodel the extracellular matrix and invade the peritoneal mesothelium. The in vitro model of transmesothelial migration of ovarian cancer cells was reproduced deducing suitable Cellular Potts Models (CPM), a grid-based 3D multiscale mathematical model, which uses an hybrid approach to describe subcellular, cellular and tissue level interactions, combining cellular automata and continuum methods. Collectively, these results indicate that CD157 expression induces a mesenchymal phenotype resulting in increased cell invasiveness.

     
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    Subjects: ovarian cancer; cell migration; matematical modeling; ectoenzyme
  3. Non-HFE hemochromatosis: insights into regulation on iron metabolisms from novel iron loading disorders.
    Author: Camaschella C.; ROETTO, Antonella; Calì A.; Totaro A.; Gasparini P.; DE GOBBI, Marco
    Published: 2000

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  4. Finding High Order Dependencies in Data
    Author: MEO, Rosa; D'Ambrosi L.
    Published: 2011
    Publisher:  Springer Verlag London ; country:GBR ; place:London

    We propose DepMiner, a method implementing a simple but effective model for the evaluation of the high-order dependencies in a set S of observations. S can be either ordered — thus forming a sequence of events — or not. DepMiner is based on Delta, a... more

     

    We propose DepMiner, a method implementing a simple but effective model for the evaluation of the high-order dependencies in a set S of observations. S can be either ordered — thus forming a sequence of events — or not. DepMiner is based on Delta, a measure of the degree of surprise of S based on the departure of the probability of S from a referential probability estimated in the condition of maximum entropy. The method is powerful: at the same time it detects significant positive dependencies as well as negative ones suitable to identify rare events. The system returns the patterns ranked by Delta; they are guaranteed to be statistically significant and their number results reduced in comparison with other methods.

     
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    Subjects: dependence; itemset; Delta value; ranking
  5. Increasing efficiency through optimal RK time integration of diffusion equations
    Author: F. CAVALLI; G. NALDI; G. PUPPO; SEMPLICE, Matteo
    Published: 2008
    Publisher:  Springer-Verlag ; country:DEU ; place:Berlin

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  6. Relaxed schemes for nonlinear evolutionary PDEs
    Author: CAVALLI F; NALDI G; PUPPO G; SEMPLICE, Matteo
    Published: 2009
    Publisher:  AMS ; country:USA ; place:Providence

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  7. Modulation of Matrix Metalloproteinases and their tissue inhibitors in haemozoin-treated human microvascular endothelial cells
    Author: PRATO, Mauro; ARESE, Paolo; S. D’Alessandro; P. E. Van den Steen; G. Opdenakker; D. Taramelli; N. Basilico
    Published: 2011

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  8. The murine homolog of the HIN 200 family, IFI 204, is constitutively expressed in myeloid and lymphoid tissues and selectively induced in the monocyte/macrophage lineage
    Author: Gariglio, M; Lembo M; Ravotto M; Zappador C; Hertel L; DE ANDREA, Marco; LANDOLFO, Santo Giuseppe
    Published: 1998

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  9. La corresponsabilità tra scuola e famiglia: ricerca-azione "star bene insieme"
    Author: Amadini, Monica; Zini, Paola
    Published: 2011
    Publisher:  Firenze University Press ; country:ITA ; place:Firenze

    To renew the school-family relationship, it is strategic to promote the educational culture of the family, recognizing it as the entity responsible for bringing up children. In this sense, the paper presents a research-action aimed at bringing out... more

     

    To renew the school-family relationship, it is strategic to promote the educational culture of the family, recognizing it as the entity responsible for bringing up children. In this sense, the paper presents a research-action aimed at bringing out the educational potential of the parents, in a process of dialogue and discussion with the educators of their children, from a common focus: the child's well-being.

     
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    Language: Italian
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    Subjects: corresponsabilità; patto educativo; benessere; cultura educativa
  10. Identità, conflitto e riscatto nella regione di Alcantara (Maranhao-Brasile)
    Author: Casella, Anna
    Published: 2009
    Publisher:  Argo ; country:ITA ; place:Perugia

    Analisi delle relazioni tra quilombolas e società brasiliana in Maranhao more

     

    Analisi delle relazioni tra quilombolas e società brasiliana in Maranhao

     
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    Language: Italian
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    Subjects: conflitto; etnicità
  11. Identità contadina in trasformazione nel Nordeste del Brasile
    Author: Casella, Anna
    Published: 2006
    Publisher:  Argo ; country:ITA ; place:Perugia

    Indagine sulla figura dei contadini e le loro pratiche in Brasile more

     

    Indagine sulla figura dei contadini e le loro pratiche in Brasile

     
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    Language: Italian
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    Subjects: identità contadina; Brasile
  12. Analisys of the running, jumping and throwing abilities since the late 1970 in young preadolescents of northern Italy
    Author: Casolo, Francesco; Frattini, Gabriella; Cereda, Ferdinando; Galvani, Christel; Mondoni, Maurizio; Vago, Paola
    Published: 2008
    Publisher:  Sport for All ; country:MYS ; place:Genting Highlands

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    Subjects: running; jumping
  13. Indigeni e migranti in Brasile: il caso degli indios macuxi-wapishana di Boa Vista (Roraima, Brasil)
    Author: Casella, Anna
    Published: 2007
    Publisher:  CSACA ; country:ITA ; place:Perugia

    Condizioni socio-culturali degli indios macuxi-wapishana e loro azioni per il recupero della identità culturale more

     

    Condizioni socio-culturali degli indios macuxi-wapishana e loro azioni per il recupero della identità culturale

     
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    Language: Italian
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    Subjects: identità; identità multiple; indios; inurbamento; povertà; deculturazione
  14. Dalla ricerca sul campo alla formazione in aula: l'esempio di due progetti di sviluppo in area rurale
    Author: Casella, Anna
    Published: 2007
    Publisher:  Aracne ; country:ITA ; place:Roma

    Analisi di alcuni progetti di cooperazione internazionale, in Brasile e Mozambico more

     

    Analisi di alcuni progetti di cooperazione internazionale, in Brasile e Mozambico

     
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    Language: Italian
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    Subjects: cooperazione; Brasile
  15. Thermocompression de cuivre poreux réalisée par dépôt électrochimique pour l’assemblage des composants semi conducteurs de puissance
    Author: Janod, Goulven; Avenas, Yvan; Chachay, Lucas; Missiaen, Jean-Michel; Daudin, Rémi; Bouvard, Didier; Schoenleber, Jonathan; Gigandet, Marie Pierre; Hihn, Jean-Yves; Khazaka, Rabih
    Published: 2023
    Publisher:  HAL CCSD

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    Parent title: Symposium du Génie Electrique ; https://hal.science/hal-04163382 ; Symposium du Génie Electrique, Jul 2023, LILLE, France
    Subjects: [SPI]Engineering Sciences [physics]
  16. Climate changes during the Lateglacial in South Europe: new insights based on pollen and brGDGTs of Lake Matese in Italy
    Author: Robles, Mary; Peyron, Odile; Ménot, Guillemette; Brugiapaglia, Elisabeta; Wulf, Sabine; Appelt, Oona; Blache, Marion; Vannière, Boris; Dugerdil, Lucas; Paura, B; Ansanay-Alex, Salomé; Cromartie, Amy; Charlet, Laurent; Guédron, Stephane; de Beaulieu, Jacques-Louis; Joannin, Sébastien
    Published: 2023
    Publisher:  HAL CCSD

    The Lateglacial (14,700-11,700 cal BP) is a key climate period marked by rapid but contrasted changes in the Northern Hemisphere. Indeed, regional climate differences have been evidenced during the Lateglacial in Europe and the Northern Mediterranean... more

     

    The Lateglacial (14,700-11,700 cal BP) is a key climate period marked by rapid but contrasted changes in the Northern Hemisphere. Indeed, regional climate differences have been evidenced during the Lateglacial in Europe and the Northern Mediterranean areas. However, past climate patterns are still debated since temperature and precipitation changes are poorly investigated towards the lower European latitudes. Lake Matese in Southern Italy is a key site in the Central Mediterranean to investigate climate patterns during the Lateglacial. This study aims to reconstruct climate changes and their impacts at Matese using a multi-proxy approach including magnetic susceptibility, geochemistry (XRF core scanning), pollen data and molecular biomarkers like branched Glycerol Dialkyl Glycerol Tetraethers (brGDGTs). Palaeotemperatures and -precipitation patterns are quantitatively inferred from pollen assemblages (multi-method approach: Modern Analogue Technique, Weighted Averaging Partial Least Squares regression, Random Forest, and Boosted Regression Trees) and brGDGTs calibrations. The results are compared to a latitudinal selection of regional climate reconstructions in Italy to better understand climate processes in Europe and in the circum-Mediterranean region. A warm Bølling–Allerød and a marked cold Younger Dryas are revealed in all climate reconstructions inferred from various proxies (chironomids, ostracods, speleothems, pollen, brGDGTs), showing no latitudinal differences in terms of temperatures across Italy. During the Bølling–Allerød, no significant changes in terms of precipitation are recorded, however, a contrasted pattern is visible during the Younger Dryas. Slightly wetter conditions are recorded south of latitude 42°N whereas dry conditions are recorded north of latitude 42°N. During the Younger Dryas, cold conditions can be attributed to the southward position of North Atlantic sea-ice and of the Polar Frontal JetStream whereas the increase of precipitation is Southern Italy seems to be linked to ...

     
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    Parent title: INQUA ; https://cnrs.hal.science/hal-04168314 ; INQUA, Jul 2023, Roma, Italy
    Subjects: [SDE]Environmental Sciences
  17. Using plant functional traits in paleoecology: a calibration study from Arid Central Asia
    Author: Dugerdil, Lucas; Violle, Cyrille; Peyron, Odile; Joannin, Sébastien; Holger, Kreeft; Denelle, Pierre; Garnier, Eric
    Published: 2023
    Publisher:  HAL CCSD

    The necessity of accurate past climate reconstructions for climate modelling is a key issue in (paleo)ecology. Especially, dryland such as Arid Central Asian deserts may spread in the next decades in surrounding steppes due to aridification. Several... more

     

    The necessity of accurate past climate reconstructions for climate modelling is a key issue in (paleo)ecology. Especially, dryland such as Arid Central Asian deserts may spread in the next decades in surrounding steppes due to aridification. Several methods already exist to convert pollen in quantitative climate (transfer functions) and biome (biomization). However, these methods are impeded by numerous biases, which could be overcome by current breakthrough in plant functional response to climate understanding.Few past pollen studies attempt to merge plant functional traits with pollen samples in order to reconstruct paleo-trait cover and functional vegetation dynamics. However, this approach has not been tested using modern samples. Especially, since the taxonomic resolution used in ecology is not the same as the one used in pollen studies (usually family or genus pollen identification), whether the phenotypic space of extant vegetation is consistent with that derived from pollen modern samples remains an open question.Here, we tested the performance of combining paleoecology and plant functional ecology to validate the use of pollen to infer the phenotypic space of past vegetation. The pollen surface sites from Arid Central Asia (n = 2393) have been extracted and the pollen-types have been used to aggregate traits (height, leaf area, leaf nitrogen, seed mass, specific leaf area and stem specific density from TRY, BIEN and GIFT databases). Then, the community-weighted mean (CWM) traits have been calculated using the pollen fractional abundances. These pollen-CWM traits have been compared with the vegetation-CWM (n = 21347). Finally, both have been related to current climate parameters.The preliminary results of this study show that the trait values aggregated by pollen-types respect the same plant economic spectrum than observed in botanical taxonomic resolution. Moreover, it validates the use of pollen as equivalent of vegetation plots to calculate the CWM. It also appears that the scheme of aggregation ...

     
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    Parent title: INQUA ; https://hal.science/hal-04168473 ; INQUA, Jul 2023, Roma, Italy
    Subjects: [SDE]Environmental Sciences
  18. The Entanglement of Landscape: Fire, Climate, and Agro-Pastoralism in the Bronze and Iron Age South Caucasus
    Author: Cromartie, Amy; Peyron, Odile; Ménot, Guillemette; Messager, Erwan; Dugerdil, Lucas; Sahakyan, Kristina; Robles, Mary; Badalyan, Ruben; Joannin, Sébastien
    Published: 2023
    Publisher:  HAL CCSD

    This paper investigates how the different social and political structures in Bronze and Iron Age Armenia shaped the surrounding steppe landscape through their agro-pastoral practices. We utilized a series of sediment cores from an altitudinal... more

     

    This paper investigates how the different social and political structures in Bronze and Iron Age Armenia shaped the surrounding steppe landscape through their agro-pastoral practices. We utilized a series of sediment cores from an altitudinal transect from around Mount Aragats, Armenia in conjunction with multiple biological and geochemical proxies (pollen, non-pollen palynomorphs, XRF, brGDGTs) and the archaeological record to untangle drivers of landscape change. This novel approach integrates multiple lines of evidence in order to understand the complexity of the entanglements of climate, fire, agro-pastoralism, and vegetation in this mountain steppe landscape.In this paper we focus on the pollen and macro-charcoal results from two sediment cores. One higher in the foothills, published in Cromartie et al. (2020), and a new record located in the valley. We find the markers of human activity corresponds with Early Bronze Age Kura-Araxes expansion of cereal agriculture into this highland region. This is followed by a decline in these markers in the Middle Bronze Age when there is a shift away from permanent settlements and increases in mobile pastoralism. Human indicators of agro-pastoralism land-usage return as communities return to practice settled agriculture from the Late Bronze Age through the Iron Age. Human landscape usage is primarily isolated to the core site in the valley through most of the record, but this changes during the Iron Age when shifts in political structure may have driven communities to utilize wetlands higher in altitude. Macro-charcoal analysis across all cores records a similar fire history which appears to be driven by climate until the last 2000 years but shifts in vegetation in the previous periods suggests humans contributed to declines in the natural fire regime. Overall, our records show that even within a small geographical area, human communities unevenly utilized the landscape and the differing social-political contexts influenced these changes. We highlight that ...

     
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    Parent title: INQUA ; https://hal.science/hal-04170132 ; INQUA, Jul 2023, Roma, Italy
    Subjects: [SDE]Environmental Sciences
  19. Recherche de micro-contaminants organiques dans l’atmosphère nuageuse : de la goutte du nuage à la pluie
    Author: Dominutti P. Borbon, A.; Klein, M.; Devidal, Jl.; Celle-Jeanton, H.; Engel, E.
    Published: 2021
    Publisher:  HAL CCSD

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    Parent title: Journée scientifique de la Fédération Recherche Environnement, ; https://hal.science/hal-04172263 ; Journée scientifique de la Fédération Recherche Environnement,, 2021, Clermont-Ferrand, France
    Subjects: [CHIM]Chemical Sciences
  20. Extraction of emotional prosody from telephone calls to hospital emergency departments
    Author: Wei, Dongjun; Embarki, Mohamed; Barakat, Oussama; Vaucherey, Coralie; Desmettre, Thibaut; Marx, Tania; Robert, Stephan
    Published: 2023
    Publisher:  HAL CCSD ; Guarant International.

    This study is based on the exploitation of telephone calls to hospital emergency departments in order to train artificial intelligence tools for the automatic recognition of vocal emotions for the purpose of improving emergency medical regulation.... more

     

    This study is based on the exploitation of telephone calls to hospital emergency departments in order to train artificial intelligence tools for the automatic recognition of vocal emotions for the purpose of improving emergency medical regulation. The main objective is to extract the most characteristic acoustic cues of vocal emotions. Very limited samples were selected from the audio databases of two University Hospitals in the Jura Arc (CHRU of Besançon in France and CHUV of Lausanne in Switzerland). Only extracts containing linguistic vocalemotions with a negative polarity (angst, anger, embarrassment and sadness) were retained for the study.These extracts were segmented and labeled, and their acoustic parameters (F0, intensity and duration) weremeasured manually. The preliminary results show that F0 modulations seem more accurate to discriminate the four vocal emotions.

     
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    Parent title: https://hal.science/hal-04182004 ; 1, Guarant International., pp.1551-1555, 2023, Proceedings of the 20th International Congress of Phonetic Sciences, 978-80-908 114-2-3
    Subjects: vocal emotion; emergency medical regulation; artificial intelligence; [SHS]Humanities and Social Sciences; [SCCO]Cognitive science
  21. The new University of Duisburg-Essen diatom digital image training data set (UDE did it v1.0)
    Author: Kloster, Michael; Burfeid-Castellanos, Andrea; Vidacović, Danijela; Mayombo, Ntambwe, Albert Serge; Dani, Mimoza; Venkataramanan, Aishwarya; Pradalier, Cedric; Laviale, Martin; Beszteri, Bánk
    Published: 2023
    Publisher:  HAL CCSD

    International audience ; Here, we introduce a collection of more than 80,000 light microscopy images of individual diatom valves or frustules, covering a broad range of taxa and morphology by more than 300 samples from 15 different river and lake... more

     

    International audience ; Here, we introduce a collection of more than 80,000 light microscopy images of individual diatom valves or frustules, covering a broad range of taxa and morphology by more than 300 samples from 15 different river and lake ecotypes. The diatoms were imaged at high resolution (< 0.1 µm/pixel) by transmitted light bright-field microscopy, with focus stacking to artificially increase focal depth up to 25 µm, allowing simultaneous observation of valve ornamentation and shape. Taken from a real-world setting, the images partly also include debris, mineral particles or other diatoms. Four experts identified over 500 diatom species; more than 100 species are represented by at least 100 specimens and about 150 by at least 50 specimens each. This data set is about one order of magnitude larger than previously published diatom data sets, and its high interspecies similarity makes it a valuable resource e.g. for benchmarking fine-grained out-of-distribution (OOD) detection, on which we present preliminary results.

     
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    Parent title: 16th International Diatom Symposium ; https://hal.univ-lorraine.fr/hal-04187561 ; 16th International Diatom Symposium, Aug 2023, Yamagata, Japan
    Subjects: Diatoms; Machine learning; Computer vision; [SDE.BE]Environmental Sciences/Biodiversity and Ecology; [INFO]Computer Science [cs]
  22. Reconnaissance automatique des diatomées : évaluation de l’influence des erreurs d’identification sur l’IBD et de l’état écologique des cours d’eau. Exemple du bassin Rhin-Meuse
    Author: Venkataramanan, Aishwarya; Usseglio-Polatera, Philippe; Heudre, David; Pradalier, Cedric; Laviale, Martin
    Published: 2023
    Publisher:  HAL CCSD

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    Language: French
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    Parent title: 41ème colloque de l’Association des Diatomistes de Langue Française (ADLaF) ; https://hal.univ-lorraine.fr/hal-04208711 ; 41ème colloque de l’Association des Diatomistes de Langue Française (ADLaF), Sep 2023, Besançon, France
    Subjects: bioindication; diatomées; taxonomie; incertitude; reconnaissance automatique; [SDV.BID]Life Sciences [q-bio]/Biodiversity; [INFO]Computer Science [cs]
  23. Production céréalière, archéodémographie et climat en Gaule à l'âge du Fer : les nouvelles perspectives de la modélisation multi-agents
    Author: Bernigaud, Nicolas; Bondeau, Alberte; Guiot, Joël; Bernard, Loup; Isoardi, Delphine; Hiriart, Eneko; Bertoncello, Frédérique; Ouriachi, Marie-Jeanne
    Published: 2021
    Publisher:  HAL CCSD

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    Language: French
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    Parent title: Matières premières en Europe au 1er Millénaire av. n. è. Exploitation, transformation, diffusion, Actes du 45e colloque de l’AFEAF ; https://hal.science/hal-04221977 ; Matières premières en Europe au 1er Millénaire av. n. è. Exploitation, transformation, diffusion, Actes du 45e colloque de l’AFEAF, 2021, Gijon, Espagne. pp.435-453
    Subjects: [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory
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  24. Experimental demonstration of Surface Acoustic Wave propagation on α-GeO2 for wireless, passive sensor design
    Author: Daniau, William; Salut, Roland; Friedt, Jean-Michel; Pena Revellez, Alexandra; Debray, Jérôme; Menaert, B; Armand, P; Papet, P; Penarier, A; Nouvel, P
    Published: 2023
    Publisher:  HAL CCSD

    International audience ; On the path towards developing passive transducers for wireless sensing in high temperature >560◦C) environments.We experimentally demonstrate the design, manufacturing and interrogation of resonators patterned on GeO2... more

     

    International audience ; On the path towards developing passive transducers for wireless sensing in high temperature >560◦C) environments.We experimentally demonstrate the design, manufacturing and interrogation of resonators patterned on GeO2 substrates.

     
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    Parent title: 2023 IEEE International Frequency Control Symposium-European Frequency ; https://hal.science/hal-04224412 ; 2023 IEEE International Frequency Control Symposium-European Frequency, May 2023, Toyama, Japan
    Subjects: surface acoustic wave; resonator; passive wireless sensor; [PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics]; [SPI.OTHER]Engineering Sciences [physics]/Other
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  25. Biological relevance and targeting of i-motif DNA
    Author: Bonnet, Hugues; Gomez, Dennis; Riou, Jean-François; Granhzam, Anton; Defrancq, Eric; Dejeu, Jérôme
    Published: 2023
    Publisher:  HAL CCSD

    International audience ; i-Motifs of DNA (hereafter, i-DNA), known in vitro for nearly three decades, are unusual, four-stranded structures, in which cytosines are intercalated via a stack of hemi-protonated C–C base pairs (CH+:C) (Fig. 1A, B). Some... more

     

    International audience ; i-Motifs of DNA (hereafter, i-DNA), known in vitro for nearly three decades, are unusual, four-stranded structures, in which cytosines are intercalated via a stack of hemi-protonated C–C base pairs (CH+:C) (Fig. 1A, B). Some of these structures have been well characterized in vitro and, because i-DNA may mirror other four-stranded G-rich structures (G-quadruplexes) present in gene promoters or at telomeres, their biological relevance is being investigated.<br&gtHowever, our knowledge about i-DNA biology is still limited: the main challenges in this regard being the strong pH dependency, flexibility, and polymorphism of i-DNA, that introduce potential bias into studies. In particular, low-pH conditions that are required for the formation of i-DNA can lead to the protonation of many ligands (including small molecules or proteins), strongly increasing their non-specific nucleic acid binding. In this context, we have developed a peptide-DNA conjugate (Fig. 1C) being able to fold into a stable i-motif at room temperature and, most importantly, at near-neutral pH.1<br&gtThe stabilized mimic of the i-motif adopted by the telomeric sequence was used to study the interactions with already reported ligands (TMPyP4, mitoxantrone, IMC-48, berberine, etc) at physiologically relevant pH by Bio-Layer Interferometry (BLI) and CD. We demonstrated that none of the reported ligands were shown to discriminate between folded and unfolded i-motif structures.2<br&gtIn conclusion, the constrained i-motif reveals to be a powerful tool for studying i-motif structure.

     
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    Source: BASE Selection for Comparative Literature
    Language: English
    Media type: Conference object
    Format: Online
    Parent title: journées scientifiques du GDR ChemBio ; https://hal.science/hal-04224588 ; journées scientifiques du GDR ChemBio, Jun 2023, STRASBOURG, France
    Subjects: [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph]; [SPI.MAT]Engineering Sciences [physics]/Materials; [SPI.NANO]Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics