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Displaying results 1 to 7 of 7.

  1. CRISPR guide RNA design
    methods and protocols
    Contributor: Fulga, Tudor A. (Herausgeber); Knapp, David J. H. F. (Herausgeber); Ferry, Quentin R. V. (Herausgeber)
    Published: [2021]
    Publisher:  Humana Press, New York, NY

    Location:
    Universitätsbibliothek Kassel, Standort Oberzwehren
    Signature:
    95 bio S 6.0 CRI
    Inter-library loan:
    Unlimited inter-library loan, copies and loan
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    Source: Union catalogues
    Contributor: Fulga, Tudor A. (Herausgeber); Knapp, David J. H. F. (Herausgeber); Ferry, Quentin R. V. (Herausgeber)
    Language: English
    Media type: Book
    Format: Print
    ISBN: 9781071606896; 1071606891
    RVK Categories: WD 5355
    Series: Methods in molecular biology ; 2162
    Subjects: Genetics; Biomedical engineering; RNA editing; CRISPR (Genetics); Genetics; Génétique; Génie biomédical; ARN; genetics; biomedical engineering; Genetics; Biomedical engineering; CRISPR (Genetics); RNA editing
    Scope: x, 286 Seiten, Illustrationen, 26 cm.
  2. Gene-environment effects on female fertility
    Author: Barban, Nicola; De Cao, Elisabetta; Francesconi, Marco
    Published: October 2021
    Publisher:  CESifo, Center for Economic Studies & Ifo Institute, Munich, Germany

    Fertility has a strong biological component generally ignored by economists. Using the UK Biobank, we analyze the extent to which genes, proxied by polygenic scores, and the environment, proxied by early exposure to the contraceptive pill diffusion,... more

    Access:
    Verlag (kostenfrei)
    Verlag (kostenfrei)
    Resolving-System (kostenfrei)

    Location:
    ZBW - Leibniz-Informationszentrum Wirtschaft, Standort Kiel
    Signature:
    DS 63
    Inter-library loan:
    No inter-library loan

     

    Fertility has a strong biological component generally ignored by economists. Using the UK Biobank, we analyze the extent to which genes, proxied by polygenic scores, and the environment, proxied by early exposure to the contraceptive pill diffusion, affect age at first sexual intercourse, age at first birth, completed family size, and childlessness. Both genes and environment exert substantial influences on all outcomes. The anticipation of sexual debut and the postponement of motherhood led by the diffusion of the pill are magnified by gene-environment interactions, while the decline in family size and the rise in childlessness associated with female emancipation are attenuated by gene-environment effects. The nature-nurture interplay becomes stronger in more egalitarian environments that empower women, allowing genes to express themselves more fully. These conclusions are confirmed by heterogenous effects across the distributions of genetic susceptibilities and exposure to environmental risks, sister fixed effects models, mother-daughter comparisons, and counterfactual simulations.

     
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    Source: Union catalogues
    Language: English
    Media type: Book
    Format: Online
    Other identifier:
    hdl: 10419/245518
    Series: CESifo working paper ; no. 9337 (2021)
    Subjects: fertility; genetics; polygenic score; contraceptive pill; nature versus nurture; social norms
    Scope: 1 Online-Ressource (circa 72 Seiten), Illustrationen
  3. The heritability of trust and trustworthiness depends on the measure of trust
    Author: Kettlewell, Nathan; Tymula, Agnieszka
    Published: September 2021
    Publisher:  IZA - Institute of Labor Economics, Bonn, Germany

    Using a large sample of 1,120 twins, we estimated the heritability of trust using four distinct measures of trust - domain-specific political trust, general self-reported trust, and incentivized behavioral trust and trustworthiness. Our results... more

    Access:
    Verlag (kostenfrei)
    Verlag (kostenfrei)
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    Location:
    ZBW - Leibniz-Informationszentrum Wirtschaft, Standort Kiel
    Signature:
    DS 4
    Inter-library loan:
    No inter-library loan

     

    Using a large sample of 1,120 twins, we estimated the heritability of trust using four distinct measures of trust - domain-specific political trust, general self-reported trust, and incentivized behavioral trust and trustworthiness. Our results highlight the importance of measuring trust in a context because its heritability differs substantially across the four measures, from 0% to 37%. Moreover, we provide the first evidence on the heritability of political trust which we estimate to be 37%. Furthermore, like the heritability, the environmental correlates of trust also vary across the different measures with political trust having the largest set of environmental covariates. The perceptions of COVID-19 health and income risks are among the unique correlates of political trust, with participants who are more worried about financial and health consequences of COVID-19, trusting politicians less, stressing the importance of trust in political leaders during a health crisis.

     
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    Source: Union catalogues
    Language: English
    Media type: Book
    Format: Online
    Other identifier:
    hdl: 10419/245785
    Series: Discussion paper series / IZA ; no. 14734
    Subjects: trust; heritability; genetics; twin study
    Scope: 1 Online-Ressource (circa 35 Seiten), Illustrationen
  4. Gene-environment effects on female fertility
    Author: Barban, Nicola; De Cao, Elisabetta; Francesconi, Marco
    Published: September 2021
    Publisher:  IZA - Institute of Labor Economics, Bonn, Germany

    Fertility has a strong biological component generally ignored by economists. Using the UK Biobank, we analyze the extent to which genes, proxied by polygenic scores, and the environment, proxied by early exposure to the contraceptive pill diffusion,... more

    Access:
    Verlag (kostenfrei)
    Verlag (kostenfrei)
    Resolving-System (kostenfrei)

    Location:
    ZBW - Leibniz-Informationszentrum Wirtschaft, Standort Kiel
    Signature:
    DS 4
    Inter-library loan:
    No inter-library loan

     

    Fertility has a strong biological component generally ignored by economists. Using the UK Biobank, we analyze the extent to which genes, proxied by polygenic scores, and the environment, proxied by early exposure to the contraceptive pill diffusion, affect age at first sexual intercourse, age at first birth, completed family size, and childlessness. Both genes and environment exert substantial influences on all outcomes. The anticipation of sexual debut and the postponement of motherhood led by the diffusion of the pill are magnified by gene-environment interactions, while the decline in family size and the rise in childlessness associated with female emancipation are attenuated by gene-environment effects. The nature-nurture interplay becomes stronger in more egalitarian environments that empower women, allowing genes to express themselves more fully. These conclusions are confirmed by heterogenous effects across the distributions of genetic susceptibilities and exposure to environmental risks, sister fixed effects models, mother-daughter comparisons, and counterfactual simulations.

     
    Export to reference management software   RIS file
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    Source: Union catalogues
    Language: English
    Media type: Book
    Format: Online
    Other identifier:
    hdl: 10419/250417
    Series: Discussion paper series / IZA ; no. 14756
    Subjects: fertility; genetics; polygenic score; contraceptive pill; nature versus nurture; social norms
    Scope: 1 Online-Ressource (circa 72 Seiten), Illustrationen
  5. Moral hazard heterogeneity: genes and health insurance influence smoking after a health shock
    Author: Biroli, Pietro; Zwyssig, Laura
    Published: March 2021
    Publisher:  IZA - Institute of Labor Economics, Bonn, Germany

    Decision-making in the realm of health behaviors, such as smoking or drinking, is influenced both by biological factors, such as genetic predispositions, as well as environmental factors, such as financial liquidity and health insurance status. We... more

    Access:
    Verlag (kostenfrei)
    Verlag (kostenfrei)
    Resolving-System (kostenfrei)

    Location:
    ZBW - Leibniz-Informationszentrum Wirtschaft, Standort Kiel
    Signature:
    DS 4
    Inter-library loan:
    No inter-library loan

     

    Decision-making in the realm of health behaviors, such as smoking or drinking, is influenced both by biological factors, such as genetic predispositions, as well as environmental factors, such as financial liquidity and health insurance status. We show how the choice of smoking after a cardio-vascular health shock is jointly determined by the interplay between these biological and environmental constraints. Individuals who suffer a health shock when uninsured are 25.6 percentage points more likely to reduce smoking, but this is true only for those who have a low index of genetic predisposition to smoking. Individuals with a low index of genetic predisposition are more strategic and flexible in their behavioral response to an external shock. This differential elasticity of response depending on your genetic variants is evidence of individual-level heterogeneity in moral hazard. These results suggest that genetic heterogeneity is a factor that should be considered when evaluating the effectiveness and fairness of health insurance policies.

     
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    Source: Union catalogues
    Language: English
    Media type: Book
    Format: Online
    Other identifier:
    hdl: 10419/236207
    Series: Discussion paper series / IZA ; no. 14176
    Subjects: moral hazard; genetics; smoking; medicare
    Scope: 1 Online-Ressource (circa 72 Seiten), Illustrationen
  6. Disparities in socio-economic status and BMI in the UK are partly due to genetic and environmental luck
    Author: Burik, Casper A. P.; Kweon, Hyeokmoon; Koellinger, Philipp
    Published: [2021]
    Publisher:  Tinbergen Institute, Amsterdam, The Netherlands

    Two family-specific lotteries take place during conception- a social lottery that determines who our parents are and which environment we grow up in, and a genetic lottery that determines which part of their genomes our parents pass on to us. The... more

    Access:
    Verlag (kostenfrei)
    Verlag (kostenfrei)
    Resolving-System (kostenfrei)

    Location:
    ZBW - Leibniz-Informationszentrum Wirtschaft, Standort Kiel
    Signature:
    DS 432
    Inter-library loan:
    No inter-library loan

     

    Two family-specific lotteries take place during conception- a social lottery that determines who our parents are and which environment we grow up in, and a genetic lottery that determines which part of their genomes our parents pass on to us. The outcomes of these lotteries create inequalities of opportunity that can translate into disparities in health and socioeconomic status. Here, we estimate a lower bound for the relevance of these two lotteries for differences in education, income and body mass index in a sample of 38,698 siblings in the UK who were born between 1937 and 1970. Our estimates are based on models that combine family-specific effects with gene-by-environment interactions. We find that the random differences between siblings in their genetic endowments clearly contribute towards inequalities in the outcomes we study. Our rough proxy of the environment people grew up in, which we derived from their place of birth, are also predictive of the studied outcomes, but not beyond the relevance of family environment. Our estimates suggest that at least 13 to 17 percent of the inequalities in education, wages and BMI in the UK are due to inequalities in opportunity that arise from the outcomes of the social and the genetic lottery.

     
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    Source: Union catalogues
    Language: English
    Media type: Book
    Format: Online
    Other identifier:
    hdl: 10419/237768
    Series: Array ; TI 2021, 035
    Subjects: inequality; income; education; BMI; genetics; polygenic index
    Scope: 1 Online-Ressource (circa 31 Seiten), Illustrationen
  7. Integrating genetics into economics
    = Het integreren van genetica in de economie
    Author: Slob, Eric Arsène Willem
    Published: [2021]
    Publisher:  Erasmus Institute of Management (ERIM), Rotterdam

    Access:
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    Verlag (kostenfrei)

    Location:
    ZBW - Leibniz-Informationszentrum Wirtschaft, Standort Kiel
    Signature:
    VS 281
    Inter-library loan:
    No inter-library loan
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    Source: Union catalogues
    Language: English
    Media type: Dissertation
    Format: Online
    ISBN: 9789058925961
    Other identifier:
    hdl: 1765/135159
    Series: ERIM PhD series in research in management ; EPS-2021-517-S&E
    Subjects: Genoeconomics; genetics; economics; Mendelian randomization; smoking; polygenic risk score; entrepreneurship; heredity; Genoeconomie; genetica; economie; Mendeliaanse randomisatie; rookgedrag; polygenetische risico score; ondernemerschap; erfelijkheid
    Scope: 1 Online-Ressource (circa 192 Seiten), Illustrationen
    Notes:

    Dissertation, Erasmus University Rotterdam, 2021