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Displaying results 1 to 25 of 92.

  1. Mord ist eine Wissenschaft
    Was schon Agatha Christie über Rechtsmedizin wusste | Die Forensikerin über Blutspuren und Fingerabdruck, Giftmord und Obduktion
    Author: Valentine, Carla
    Published: 2022
    Publisher:  Droemer eBook, München

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  2. Placebo-Effekte
    heilende Zeichen, toxische Texte, ansteckende Informationen
    Author: Andree, Martin
    Published: 2018; ©2018
    Publisher:  Wilhelm Fink, Paderborn

    Sind Zeichen und Medien in der Lage, Wirkungen auszulösen, die sich mit denjenigen von Drogen und Arzneimitteln vergleichen lassen? Die Studie erschließt die Potenzen ›heilender Zeichen‹ und ›toxischer Texte‹ sowie die Bedeutungswirkungen von... more

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    Universität Potsdam, Universitätsbibliothek
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    Sind Zeichen und Medien in der Lage, Wirkungen auszulösen, die sich mit denjenigen von Drogen und Arzneimitteln vergleichen lassen? Die Studie erschließt die Potenzen ›heilender Zeichen‹ und ›toxischer Texte‹ sowie die Bedeutungswirkungen von Placebo-Effekten. Im Gegensatz zu breit erforschten Effekten wie Gänsehaut oder Herzrasen wurden genuin pharmakologische körperliche Wirkungen in den Medien- und Kulturwissenschaften bislang allenfalls marginal beschrieben. Die Studie erschließt die umfangreiche Phänomenologie der erheblichen biophysiologischen Beeinflussung des Körpers durch semantisch-mediale Inputs, die im günstigen Fall organische Krankheiten heilen, aber auch schädliche Effekte verursachen können, bis hin zu ›Tod durch Zeichen‹. Dabei dienen die Bedeutungswirkungen von Placebo-Effekten als Paradigma der kultur- und medienwissenschaftlichen Untersuchung. Sie liefert damit aus einer neuen Perspektive auch eine umfangreiche Validierung der verschiedenen ›Körperdiskurse‹ bzw. ›Krankheitskulturen‹ aus den siebziger und achtziger Jahren.

     
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    Source: Union catalogues
    Language: German
    Media type: Ebook
    Format: Online
    ISBN: 9783846762752
    RVK Categories: AP 13550 ; AP 15580 ; MR 2400 ; EC 5410
    Subjects: Placebo effect; Placebos; Medien; Doping; Krankheit; Heilung; Pharmakologie; Placebo; Zeichen
    Scope: 1 Online-Ressource (459 Seiten), Illustrationen (teilweise farbig)
    Notes:

    Literaturverzeichnis: Seite 387-435
  3. Experimenteller Beitrag zur Klärung der Ursachen der Anreicherung von 137Cs nach radioaktivem fall out
    Author: Pfleger, K.

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    Source: Union catalogues
    Language: German
    Media type: Article (journal)
    Format: Online
    ISSN: 1432-1912
    Other identifier:
    Parent title:
    In:: Naunyn-Schmiedeberg's archives of pharmacology; Berlin ; Heidelberg : Springer, 1873-; 246, Heft 1 (1.1.1963), 77-78, 1.1963; Online-Ressource
    Subjects: Pharmakologie; Literatur; Hund; Infektion; Infektiologie
    Other subjects: Naeher, Julius (1824-1911); (lcsh)Medicine.; (lcsh)Neurosciences.; (lcsh)Pharmacology.; Biomedicine.; Pharmacology/Toxicology.; Neurosciences.
    Scope: Online-Ressource, online resource.
  4. Placebo-Effekte
    heilende Zeichen, toxische Texte, ansteckende Informationen
    Author: Andree, Martin
    Published: [2018]; © 2018
    Publisher:  Wilhelm Fink, Paderborn

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    Universitätsbibliothek Eichstätt-Ingolstadt
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    Hochschule Kempten, Hochschulbibliothek
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    Hochschule Landshut, Hochschule für Angewandte Wissenschaften, Bibliothek
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    Universitätsbibliothek der LMU München
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    Content information
    Volltext (URL des Erstveröffentlichers)
    Source: Union catalogues
    Language: German
    Media type: Ebook
    Format: Online
    ISBN: 9783846762752
    Other identifier:
    RVK Categories: AP 17120 ; EC 2490 ; LC 56000
    Subjects: Placebo Effect; Placebos; Medien; Heilung; Wirkung; Physiologie
    Other subjects: Placebo; Heilung; Medien; Krankheit; Doping; Zeichen; Pharmakologie
    Scope: 1 Online-Ressource (459 Seiten), Illustrationen, Diagramme
    Notes:

    Literaturverzeichnis Seiten [387]-435
  5. Hippocratic recipes
    oral and written transmission of pharmacological knowledge in fifth- and fourth-century Greece
    Author: Totelin, Laurence M. V.
    Published: 2009
    Publisher:  Brill, Leiden

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    Source: Union catalogues
    Language: English
    Media type: Ebook
    Format: Online
    ISBN: 9789004171541; 9004171541
    RVK Categories: FH 26003 ; LG 7500
    Series: Studies in ancient medicine ; v. 34
    Subjects: Geschichte; Wissen; Pharmacology; Drug development; Schriftlichkeit; Arzneiverordnung; Oral history; Pharmakologie
    Other subjects: Hippocrates; Hippocrates (v460-v370)
    Scope: xviii, 366 p.
    Notes:

    Includes bibliographical references (p. [303]-326) and indexes

    Oral transmission of medical knowledge and written recipes -- The history of the written catalogues of recipes -- Hippocratic recipes between home remedies and haute medecine -- Imports, geographical determinism, and influences : the use of exotic and luxury ingredients in the Hippocratic catalogues of recipes -- Fertility and sex : the symbolism attached to some of the ingredients of the Hippocratic gynaecological recipes -- Reading, studying, and using the Hippocratic catalogues of recipes -- The afterlife of Hippocratic recipes
  6. Hippocratic recipes
    oral and written transmission of pharmacological knowledge in fifth- and fourth-century Greece
    Author: Totelin, Laurence M. V.
    Published: 2009
    Publisher:  Brill, Leiden ; Boston

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    Ostbayerische Technische Hochschule Amberg-Weiden / Hochschulbibliothek Amberg
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    Source: Union catalogues
    Language: English
    Media type: Dissertation
    Format: Online
    ISBN: 9789047424864; 9047424867
    Other identifier:
    RVK Categories: FH 26003 ; LG 7500
    Series: Studies in ancient medicine ; Volume 34
    Subjects: Geschichte; Wissen; MEDICAL / Drug Guides; MEDICAL / Pharmacology; MEDICAL / Pharmacy; MEDICAL / Nursing / Pharmacology; Pharmaceutical Preparations / History; Drug Compounding / History; Drug Prescriptions / History; Greek World; History, Ancient; Pharmacology / History; Geschichte; Medizin; Wissen; Drug Compounding; Drug Prescriptions; Drug development; Greek World; History, Ancient; Pharmaceutical Preparations; Pharmacology; Pharmacology; Pharmacology; Drug development; Schriftlichkeit; Pharmakologie; Arzneiverordnung; Oral history
    Other subjects: Hippocrates / Knowledge / Pharmacology; Hippocrates; Hippocrates; Hippocrates; Hippocrates (v460-v370)
    Scope: 1 Online-Ressource (xviii, 366 Seiten), Karten
    Notes:

    Includes bibliographical references (pages 303-326) and indexes

    Oral transmission of medical knowledge and written recipes -- The history of the written catalogues of recipes -- Hippocratic recipes between home remedies and haute medecine -- Imports, geographical determinism, and influences : the use of exotic and luxury ingredients in the Hippocratic catalogues of recipes -- Fertility and sex : the symbolism attached to some of the ingredients of the Hippocratic gynaecological recipes -- Reading, studying, and using the Hippocratic catalogues of recipes -- The afterlife of Hippocratic recipes

    Dissertation, University College London,
  7. Pharmakofictions - Spekulationen mit prekären Stoffen in zeitgenössischer Science-Fiction und Philosophie
    Author: Dickmann, Georg
    Published: [2023]; © 2023
    Publisher:  transcript, Bielefeld

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    Bayerische Staatsbibliothek
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    Universitätsbibliothek Regensburg
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    Source: Union catalogues
    Language: German
    Media type: Dissertation
    Format: Online
    ISBN: 9783839465837
    Other identifier:
    RVK Categories: EC 6745
    Series: Wissen der Künste ; Band 4
    Subjects: Neuer Materialismus; Science-Fiction; Pharmakologie; Biopolitik
    Other subjects: Science-Fiction; Materialismus; Neuer Materialismus; Biopolitik; Pharmakon; Stoffgeschichte; Literatur; Film; Pharmakologie; Wirkstoff; Subjektivierung; Körper; Kultur; Philosophie des Körpers; Gender Studies; Literaturwissenschaft; Queer Theory; Kulturwissenschaft; Science-fiction; Materialism; New Materialism; Biopolitics; Pharmacon; Substance History; Literature; Pharmacology; Active Ingredient; Subjectivation; Body; Culture; Philosophy of Body; Literary Studies; Cultural Studies
    Scope: 1 Online-Ressource (311 Seiten), Illustrationen
    Notes:

    Dissertation, Universität der Künste Berlin, 2021
  8. Study on the economic impact of supplementary protection certificates, pharmaceutical incentives and rewards in Europe
    final report
    Published: 2018
    Publisher:  Publications Office of the European Union, Luxembourg

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    Universitätsbibliothek Braunschweig
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    ZBW - Leibniz-Informationszentrum Wirtschaft, Standort Kiel
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    Source: Union catalogues
    Language: English
    Media type: Ebook
    Format: Online
    ISBN: 9789279680502
    Other identifier:
    Subjects: Arzneimittelrecht; Pharmakologie; Innovation; Arzneimittelmarkt; EU-Staaten
    Scope: 1 Online-Ressource (circa 391 Seiten), Illustrationen
  9. Pharmakofictions - Spekulationen mit prekären Stoffen in zeitgenössischer Science-Fiction und Philosophie
    Author: Dickmann, Georg
    Published: 2023
    Publisher:  transcript Verlag, Bielefeld

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    Source: Union catalogues
    Language: German
    Media type: Dissertation
    Format: Online
    ISBN: 9783839465837
    Other identifier:
    9783839465837
    Edition: 1. Auflage
    Series: Wissen der Künste ; 4
    Subjects: Arzneimittel <Motiv>; Droge <Motiv>; Biopolitik <Motiv>; Science-Fiction; Literatur; Philosophie; Biopolitik; Materialität; Wissenschaft; Wissen
    Other subjects: Deleuze, Gilles (1925-1995); (Produktform)Digital download; (Produktform (spezifisch))PDF; (Zielgruppe)Fachpublikum/ Wissenschaft; (VLB-WN)9521; (DDC Deutsch 22)100; (DDC Deutsch 22)300; (DDC Deutsch 22)800; (BISAC Subject Heading)SOC032000; (BIC subject category)HP; (BIC subject category)JFSJ; (BIC subject category)DSB; Science-Fiction; Materialismus; Neuer Materialismus; Biopolitik; Pharmakon; Stoffgeschichte; Literatur; Film; Pharmakologie; Wirkstoff; Subjektivierung; Körper; Kultur; Philosophie des Körpers; Gender Studies; Literaturwissenschaft; Queer Theory; Kulturwissenschaft; Science-fiction; Materialism; New Materialism; Biopolitics; Pharmacon; Substance History; Literature; Pharmacology; Active Ingredient; Subjectivation; Body; Culture; Philosophy of Body; Literary Studies; Cultural Studies;; Science-Fiction; Materialismus; Neuer Materialismus; Biopolitik; Pharmakon; Stoffgeschichte; Literatur; Film; Pharmakologie; Wirkstoff; Subjektivierung; Körper; Kultur; Philosophie des Körpers; Gender Studies; Literaturwissenschaft; Queer Theory; Kulturwissenschaft; Materialism; New Materialism; Biopolitics; Pharmacon; Substance History; Literature; Pharmacology; Active Ingredient; Subjectivation; Body; Culture; Philosophy of Body; Literary Studies; Cultural Studies
    Scope: 1 Online-Ressource, 316 Seiten, 1 SW-Abbildung, 15 Farbabbildungen
    Notes:

    Dissertation, Universität der Künste Berlin, 2021
  10. Placebo-Effekte
    heilende Zeichen, toxische Texte, ansteckende Informationen
    Author: Andree, Martin
    Published: [2018]; © 2018
    Publisher:  Wilhelm Fink, Paderborn

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    Alice Salomon Hochschule Berlin, Bibliothek
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    Humboldt-Universität zu Berlin, Universitätsbibliothek, Jacob-und-Wilhelm-Grimm-Zentrum
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    Universität Potsdam, Universitätsbibliothek
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    Content information
    Volltext (URL des Erstveröffentlichers)
    Source: Union catalogues
    Language: German
    Media type: Ebook
    Format: Online
    ISBN: 9783846762752
    Other identifier:
    RVK Categories: AP 17120 ; EC 2490 ; LC 56000
    Subjects: Placebo Effect; Placebos; Medien; Heilung; Wirkung; Physiologie
    Other subjects: Placebo; Heilung; Medien; Krankheit; Doping; Zeichen; Pharmakologie
    Scope: 1 Online-Ressource (459 Seiten), Illustrationen, Diagramme
    Notes:

    Literaturverzeichnis Seiten [387]-435
  11. Hippocratic recipes
    oral and written transmission of pharmacological knowledge in fifth- and fourth-century Greece
    Author: Totelin, Laurence M. V.
    Published: 2009
    Publisher:  Brill, Leiden ; Boston

    Location:
    Humboldt-Universität zu Berlin, Universitätsbibliothek, Jacob-und-Wilhelm-Grimm-Zentrum
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    Content information
    Source: Union catalogues
    Language: English
    Media type: Dissertation
    Format: Online
    ISBN: 9789047424864; 9047424867
    Other identifier:
    RVK Categories: FH 26003 ; LG 7500
    Series: Studies in ancient medicine ; Volume 34
    Subjects: Geschichte; Wissen; MEDICAL / Drug Guides; MEDICAL / Pharmacology; MEDICAL / Pharmacy; MEDICAL / Nursing / Pharmacology; Pharmaceutical Preparations / History; Drug Compounding / History; Drug Prescriptions / History; Greek World; History, Ancient; Pharmacology / History; Geschichte; Medizin; Wissen; Drug Compounding; Drug Prescriptions; Drug development; Greek World; History, Ancient; Pharmaceutical Preparations; Pharmacology; Pharmacology; Pharmacology; Drug development; Schriftlichkeit; Pharmakologie; Arzneiverordnung; Oral history
    Other subjects: Hippocrates / Knowledge / Pharmacology; Hippocrates; Hippocrates; Hippocrates; Hippocrates (v460-v370)
    Scope: 1 Online-Ressource (xviii, 366 Seiten), Karten
    Notes:

    Includes bibliographical references (pages 303-326) and indexes

    Oral transmission of medical knowledge and written recipes -- The history of the written catalogues of recipes -- Hippocratic recipes between home remedies and haute medecine -- Imports, geographical determinism, and influences : the use of exotic and luxury ingredients in the Hippocratic catalogues of recipes -- Fertility and sex : the symbolism attached to some of the ingredients of the Hippocratic gynaecological recipes -- Reading, studying, and using the Hippocratic catalogues of recipes -- The afterlife of Hippocratic recipes

    Dissertation, University College London,
  12. Pharmakofictions - Spekulationen mit prekären Stoffen in zeitgenössischer Science-Fiction und Philosophie
    Author: Dickmann, Georg
    Published: [2023]; © 2023
    Publisher:  transcript, Bielefeld

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    Humboldt-Universität zu Berlin, Universitätsbibliothek, Jacob-und-Wilhelm-Grimm-Zentrum
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    Staatsbibliothek zu Berlin - Preußischer Kulturbesitz, Haus Unter den Linden
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    Source: Staatsbibliothek zu Berlin
    Language: German
    Media type: Dissertation
    Format: Online
    ISBN: 9783839465837
    Other identifier:
    RVK Categories: EC 6745
    Series: Wissen der Künste ; Band 4
    Subjects: Neuer Materialismus; Science-Fiction; Pharmakologie; Biopolitik
    Other subjects: Science-Fiction; Materialismus; Neuer Materialismus; Biopolitik; Pharmakon; Stoffgeschichte; Literatur; Film; Pharmakologie; Wirkstoff; Subjektivierung; Körper; Kultur; Philosophie des Körpers; Gender Studies; Literaturwissenschaft; Queer Theory; Kulturwissenschaft; Science-fiction; Materialism; New Materialism; Biopolitics; Pharmacon; Substance History; Literature; Pharmacology; Active Ingredient; Subjectivation; Body; Culture; Philosophy of Body; Literary Studies; Cultural Studies
    Scope: 1 Online-Ressource (311 Seiten), Illustrationen
    Notes:

    Dissertation, Universität der Künste Berlin, 2021
  13. Sharing RD risk in healthcare via FDA hedges
    Author: Jørring, Adam; Lo, Andrew W.; Philipson, Tomas J.; Singh, Manita; Thakor, Richard T.
    Published: March 28, 2017
    Publisher:  MIT Sloan School of Management, [Cambridge, MA]

    The high cost of capital for firms conducting medical research and development (R&D) has been partly attributed to the government risk facing investors in medical innovation. This risk slows down medical innovation because investors must be... more

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    Universitätsbibliothek Braunschweig
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    Helmut-Schmidt-Universität, Universität der Bundeswehr Hamburg, Universitätsbibliothek
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    ZBW - Leibniz-Informationszentrum Wirtschaft, Standort Kiel
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    VS 67 (5194)
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    The high cost of capital for firms conducting medical research and development (R&D) has been partly attributed to the government risk facing investors in medical innovation. This risk slows down medical innovation because investors must be compensated for it. We propose new and simple financial instruments, Food and Drug Administration (FDA) hedges, to allow medical R&D investors to better share the pipeline risk associated with FDA approval with broader capital markets. Using historical FDA approval data, we discuss the pricing of FDA hedges and mechanisms under which they can be traded and estimate issuer returns from offering them. Using various unique data sources, we find that FDA approval risk has a low correlation across drug classes as well as with other assets and the overall market. We argue that this zero-beta property of scientific FDA risk could be a main source of gains from trade between issuers of FDA hedges looking for diversified investments and developers looking to offload the FDA approval risk. We offer proof of concept of the feasibility of trading this type of pipeline risk by examining related securities issued around mergers and acquisitions activity in the drug industry. Overall, our argument is that, by allowing better risk sharing between those investing in medical innovation and capital markets more generally, FDA hedges could ultimately spur medical innovation and improve the health of patients

     
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    Volltext (kostenfrei)
    Source: Union catalogues
    Language: English
    Media type: Book
    Format: Online
    Other identifier:
    Edition: This draft: 28 March 2017
    Series: MIT Sloan School working paper ; 5194 (17)
    MIT Sloan Research Paper ; No. 5194-17
    Subjects: Pharmakologie; Forschungskosten; Arzneimittelrecht; Genehmigung; Optionsgeschäft; Hedging; Risikomanagement; USA
    Scope: 1 Online-Ressource (circa 44 Seiten), Illustrationen
    Notes:

    FDA = Food and Drug Administration
  14. Placebo-Effekte
    heilende Zeichen, toxische Texte, ansteckende Informationen
    Author: Andree, Martin
    Published: 2018; ©2018
    Publisher:  Wilhelm Fink, Paderborn

    Sind Zeichen und Medien in der Lage, Wirkungen auszulösen, die sich mit denjenigen von Drogen und Arzneimitteln vergleichen lassen? Die Studie erschließt die Potenzen ›heilender Zeichen‹ und ›toxischer Texte‹ sowie die Bedeutungswirkungen von... more

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    Verlag (lizenzpflichtig)

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    Universitätsbibliothek Braunschweig
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    Technische Universität Chemnitz, Universitätsbibliothek
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    Hochschule für Bildende Künste Dresden, Bibliothek
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    Sächsische Landesbibliothek - Staats- und Universitätsbibliothek Dresden
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    Zentrale Hochschulbibliothek Flensburg
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    Technische Universität Bergakademie Freiberg, Bibliothek 'Georgius Agricola'
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    Bibliothek der Pädagogischen Hochschule Freiburg/Breisgau
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    Universitäts- und Landesbibliothek Sachsen-Anhalt / Zentrale
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    Hochschulbibliothek Karlsruhe (PH)
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    eBook UTB scholars
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    Hochschule für Musik und Theater 'Felix Mendelssohn Bartholdy' Leipzig, Bibliothek und Archiv
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    Sind Zeichen und Medien in der Lage, Wirkungen auszulösen, die sich mit denjenigen von Drogen und Arzneimitteln vergleichen lassen? Die Studie erschließt die Potenzen ›heilender Zeichen‹ und ›toxischer Texte‹ sowie die Bedeutungswirkungen von Placebo-Effekten. Im Gegensatz zu breit erforschten Effekten wie Gänsehaut oder Herzrasen wurden genuin pharmakologische körperliche Wirkungen in den Medien- und Kulturwissenschaften bislang allenfalls marginal beschrieben. Die Studie erschließt die umfangreiche Phänomenologie der erheblichen biophysiologischen Beeinflussung des Körpers durch semantisch-mediale Inputs, die im günstigen Fall organische Krankheiten heilen, aber auch schädliche Effekte verursachen können, bis hin zu ›Tod durch Zeichen‹. Dabei dienen die Bedeutungswirkungen von Placebo-Effekten als Paradigma der kultur- und medienwissenschaftlichen Untersuchung. Sie liefert damit aus einer neuen Perspektive auch eine umfangreiche Validierung der verschiedenen ›Körperdiskurse‹ bzw. ›Krankheitskulturen‹ aus den siebziger und achtziger Jahren.

     
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    Source: Union catalogues
    Language: German
    Media type: Ebook
    Format: Online
    ISBN: 9783846762752
    Other identifier:
    9783846762752
    RVK Categories: AP 13550 ; AP 15580 ; MR 2400 ; EC 5410
    Subjects: Placebo effect; Placebos; Nocebo-Effekt; Performativität; Medien; Doping; Krankheit; Heilung; Pharmakologie; Placebo; Zeichen
    Scope: 1 Online-Ressource (459 Seiten), Illustrationen (teilweise farbig)
    Notes:

    Literaturverzeichnis: Seite 387-435
  15. Nya läkemedel i Sverige
    innovationshöjd, prissättning och marknadsframgång
    Published: 2002
    Publisher:  Ekonomiska Forskningsinst., Stockholm

    Location:
    ZBW - Leibniz-Informationszentrum Wirtschaft, Standort Kiel
    Signature:
    W 820 (505)
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    ZBW - Leibniz-Informationszentrum Wirtschaft, Standort Kiel
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    DS 324 (505)
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    Source: Union catalogues
    Language: Swedish
    Media type: Book
    Format: Online
    Other identifier:
    hdl: 10419/56355
    Edition: [Elektronische Ressource], Rev. August 28, 2002
    Series: SSE/EFI working paper series in economics and finance ; 505
    Subjects: Arzneimittel; Schweden; Pharmakologie
    Scope: Online-Ressource (PDF-Datei: 39 S., 985,53 KB)
    Notes:

    nBibliography

    Zsfassung in schwed. Sprache
  16. Does public scientific research complement industry R & D investment?
    The case of NIH supported basic and clinical research and pharmaceutical industry R & D
    Published: 2005
    Publisher:  ZEW Zentrum für Europäische Wirtschaftsforschung, Mannheim

    This research investigates the hypothesis that publicly funded scientific research complements private R&D investment in the pharmaceutical industry. New microlevel data on public research investment by the U.S. National Institutes of Health allow... more

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    This research investigates the hypothesis that publicly funded scientific research complements private R&D investment in the pharmaceutical industry. New microlevel data on public research investment by the U.S. National Institutes of Health allow measures of basic and clinical research in seven medical areas to be included in a distributed lag model explaining pharmaceutical R&D investment. Using a panel of therapeutic classes observed over eighteen years, the analysis finds strong evidence that public basic and clinical research are complementary to pharmaceutical R&D and, thereby, stimulate private industry investment. However, differences in the relevance and degree of scientific and market uncertainty between basic and clinical public research lead to differences in the magnitude and timing of the pharmaceutical investment response. The results indicate that a dollar increase in public basic research stimulates an additional $8.38 in pharmaceutical investment after eight years. The industry R&D response to public clinical research is smaller in magnitude and shorter in duration with a dollar increase in public clinical research stimulating an additional $2.35 in pharmaceutical investment over a three year period.

     
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    Source: Union catalogues
    Language: English
    Media type: Book
    Format: Online
    Series: Discussion paper / ZEW ; 05-75
    Subjects: Öffentliche Forschung; Industrieforschung; Investition; Schätzung; USA; Pharmakologie
    Scope: Online-Ressource, 40 S., Text, graph. Darst
  17. Children in need of medical innovation
    Published: July 2004
    Publisher:  Techn. Univ., Inst. für Volkswirtschaftslehre, Darmstadt

    Children are therapeutic orphans and an underprivileged group in innovations derived from drug therapy. As the innovation process of pharmaceuticals is a long, risky and very costly business, economists typically emphasise lack of profit incentives... more

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    Children are therapeutic orphans and an underprivileged group in innovations derived from drug therapy. As the innovation process of pharmaceuticals is a long, risky and very costly business, economists typically emphasise lack of profit incentives and small market size as the most important obstacles to child-related innovative activity. Moreover, as new drugs need to be tested in medical trials, there are ethical concerns leading to a climate of reluctance towards medical trials on persons who are not able to give their "informed consent". Particularly in Germany, due to various reasons, a rather restrictive legislation is to be assumed, characterized by the idea of putting the protection of the individual human being before a more utilitarian view. Thus, economic incentives, legal restrictions and ethical concerns seem to be responsible for the lack of innovative activity targeted at drugs for children, though social cost-benefit considerations (i.e. welfare analysis) would most probably predict a high gain from the introduction of critical innovations. Grounded on a highly interdisciplinary view based on medical, pharmaceutical, psychopharmaceutical, psychotherapeutic and economic research as well as on ethical restrictions, this survey aims at analysing channels of influence that might be helpful both in the analysis of the innovation process of drugs for children, and in improving the uncertain situation of pediatric therapy

     
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    Language: English
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    Other identifier:
    hdl: 10419/22518
    Series: Darmstadt discussion papers in economics ; 135
    Subjects: Kinder; Medizin; Innovation; Marktversagen; Kosten-Nutzen-Analyse; Pharmakologie
    Scope: Online-Ressource, 22 p., text
  18. Innovación en medicamentos, precios y salud
    Published: Jan. 2005
    Publisher:  Dep. d'Economia i Empresa, UPF, Barcelona

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    Universitätsbibliothek Braunschweig
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    W 1141 (807)
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    Source: Union catalogues
    Language: Spanish
    Media type: Book
    Format: Online
    Series: Working paper / Departament d'Economica i Empresa, UPF ; 807
    Subjects: Innovation; Arzneimittel; Arzneimittelmarkt; Regulierung; Pharmakologie
    Scope: Online-Ressource, 20 p. = 66 Kb, text
  19. Evaluation and Learning in R&D Investment
    Author: Frankel, Alex; Krieger, Joshua L.; Li, Danielle; Papanikolaou, Dimitris
    Published: May 2023
    Publisher:  National Bureau of Economic Research, Cambridge, Mass

    We examine the role of spillover learning in shaping the value of exploratory versus incremental R&D. Using data from drug development, we show that novel drug candidates generate more knowledge spillovers than incremental ones. Despite being less... more

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    We examine the role of spillover learning in shaping the value of exploratory versus incremental R&D. Using data from drug development, we show that novel drug candidates generate more knowledge spillovers than incremental ones. Despite being less likely to reach regulatory approval, they are more likely to inspire subsequent successful drugs. We introduce a model where firms are better able to evaluate the viability of incremental drugs, but where investing in novel drugs helps firms learn about future projects. Firms appear to put more value on evaluation versus learning, and those patterns are in-part driven by the appropriability of spillovers

     
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    Source: Union catalogues
    Language: English
    Media type: Book
    Format: Online
    Series: NBER working paper series ; no. w31290
    Subjects: Pharmakologie; Pharmaindustrie; Arzneimittel; Industrieforschung; Wissenstransfer; Investition; Theorie; Portfolio Choice; Investment Decisions; Chemicals; Rubber; Drugs; Biotechnology; Plastics; Innovation and Invention: Processes and Incentives; Management of Technological Innovation and R&D; Intellectual Property and Intellectual Capital
    Scope: 1 Online-Ressource, illustrations (black and white)
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    Hardcopy version available to institutional subscribers
  20. 'We Are Not Guinea Pigs'
    The Effects of Disclosure of Medical Misconduct on Vaccine Compliance
    Author: Archibong, Belinda; Annan, Francis
    Published: September 2023
    Publisher:  National Bureau of Economic Research, Cambridge, Mass

    In 1996, following an epidemic, Pfizer tested a new drug on 200 children in Muslim Nigeria. 11 children died while others were disabled. We study the effects of the disclosure, in 2000, of the deaths of Muslim children in the Pfizer trials on vaccine... more

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    In 1996, following an epidemic, Pfizer tested a new drug on 200 children in Muslim Nigeria. 11 children died while others were disabled. We study the effects of the disclosure, in 2000, of the deaths of Muslim children in the Pfizer trials on vaccine compliance among Muslim mothers. Muslim mothers reduced routine vaccination of children born after the 2000 disclosure. The effect was stronger for educated mothers and mothers residing in minority Muslim neighborhoods. The disclosure did not affect other health-seeking behavior of mothers. The results illustrate the potential spillover effects of perceived medical malpractice on future vaccine hesitancy

     
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    Source: Union catalogues
    Language: English
    Media type: Book
    Format: Online
    Series: NBER working paper series ; no. w31655
    Subjects: Pharmaindustrie; Pharmakologie; Kriminalität; Arzneimittel; Kinder; Sterblichkeit; Konsumentenverhalten; Mütter; Muslime; Impfung; Nigeria; Search; Learning; Information and Knowledge; Communication; Belief; Unawareness; Health Behavior; Health and Inequality; Government Policy; Regulation; Public Health; Microeconomic Analyses of Economic Development; Religion
    Scope: 1 Online-Ressource, illustrations (black and white)
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  21. Investigator Racial Diversity and Clinical Trial Participation
    Author: Alsan, Marcella; Campbell, Romaine A.; Leister, Lukas; Ojo, Ayotomiwa
    Published: September 2023
    Publisher:  National Bureau of Economic Research, Cambridge, Mass

    We investigate whether increased racial diversity of clinical trial principal investigators could increase the enrollment of Black patients, which currently lags population and disease-burden shares. We conducted a survey experiment in which... more

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    We investigate whether increased racial diversity of clinical trial principal investigators could increase the enrollment of Black patients, which currently lags population and disease-burden shares. We conducted a survey experiment in which respondents were shown a photo of a current NIH investigator in which race (Black/White) was randomized. Sex was also randomized as a relevant benchmark. Black respondents reported 0.35 standard deviation units higher interest in participating in a clinical study led by a race concordant investigator (a 12.6% increase). Sex concordance had no effect. Further analyses indicate that perceived trustworthiness and attractiveness are the most important factors explaining these results

     
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    Source: Union catalogues
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    Series: NBER working paper series ; no. w31732
    Subjects: Medizinische Behandlung; Arzneimittel; Innovation; Pharmakologie; Ethnische Gruppe; Ethnische Diskriminierung; USA; Health and Inequality; Government Policy; Regulation; Public Health
    Scope: 1 Online-Ressource, illustrations (black and white)
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  22. Improving Regulation for Innovation
    Evidence from China's Pharmaceutical Industry
    Author: Jia, Ruixue; Ma, Xiao; Yang, Jianan; Zhang, Yiran
    Published: December 2023
    Publisher:  National Bureau of Economic Research, Cambridge, Mass

    This study investigates how enhanced regulation can promote innovation, focusing on the impacts of a significant regulatory reform in China's pharmaceutical sector implemented in 2015. Inspired by regulatory practices in the U.S., the reform aimed to... more

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    This study investigates how enhanced regulation can promote innovation, focusing on the impacts of a significant regulatory reform in China's pharmaceutical sector implemented in 2015. Inspired by regulatory practices in the U.S., the reform aimed to address application backlogs and reduce administrative waiting time for new drug development. Using data at the drug and firm levels during 2012--2021, we make three main findings: (1) drug categories experiencing improved approval times witnessed a surge in investigational new drug applications and related clinical trials; (2) despite little improvement in innovativeness (measured by novel targets unexplored by U.S. counterparts) within drug categories, the reform led to changes in firm composition, attracting innovative new firms and boosting overall drug innovativeness; and (3) the market recognized the improvement in drug innovation, as reflected in stock price adjustments post new drug registrations after the reform. Our findings demonstrate that regulatory barriers can hinder the entry of innovative firms and suggest that latecomers could boost their innovation potential by adopting specific, effective regulatory practices from frontier countries

     
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    Source: Union catalogues
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    Series: NBER working paper series ; no. w31976
    Subjects: Pharmaindustrie; Regulierung; Pharmakologie; Arzneimittel; Innovation; China; Firm Behavior: Empirical Analysis; Health and Economic Development; Government Policy; Regulation; Public Health; Innovation and Invention: Processes and Incentives
    Scope: 1 Online-Ressource, illustrations (black and white)
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  23. Financing pharmaceutical innovation
    how much should poor countries contribute
    Published: 26 Nov. 2003
    Publisher:  Georgetown Univ., Georgetown College, School of Foreign Service, Washington, DC

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    Universitätsbibliothek Braunschweig
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    W 555 (03.15)
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    Series: Working papers / Georgetown University, Economics Department ; 03,15
    Subjects: Arzneimittel; Preismanagement; Ramsey-Preis; Monopol; Preisdifferenzierung; Forschung; Theorie; Pharmakologie; TRIPS
    Scope: Online-Ressource, 27 p., text, ill
  24. Patentes, regulación de precios e innovación en la industria farmacéutica
    Published: 2004
    Publisher:  Dep. d'Economia i Empresa, UPF, Barcelona

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    Universitätsbibliothek Braunschweig
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    W 1141 (754)
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    Language: Spanish
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    Series: Working paper / Departament d'Economica i Empresa, UPF ; 754
    Subjects: Pharmaindustrie; Preisregulierung; Industriepolitik; Gesundheitspolitik; Welt; Pharmakologie
    Scope: Online-Ressource, 19 p. = 68 Kb, text
  25. Children in need of medical innovation
    Published: 2004
    Publisher:  ZEW Zentrum für Europäische Wirtschaftsforschung, Mannheim

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    Universitätsbibliothek Braunschweig
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    Niedersächsische Staats- und Universitätsbibliothek Göttingen
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    Edition: [Elektronische Ressource]
    Series: Discussion paper / ZEW ; 04-49
    Subjects: Kinder; Medizin; Innovation; Marktversagen; Kosten-Nutzen-Analyse; Pharmakologie
    Scope: Online-Ressource, 30 p., text