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Displaying results 1 to 15 of 15.

  1. CRISPR guide RNA design
    methods and protocols
    Contributor: Fulga, Tudor A. (Herausgeber); Knapp, David J. H. F. (Herausgeber); Ferry, Quentin R. V. (Herausgeber)
    Published: [2021]
    Publisher:  Humana Press, New York, NY

    Location:
    Universitätsbibliothek Kassel, Standort Oberzwehren
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    95 bio S 6.0 CRI
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    Contributor: Fulga, Tudor A. (Herausgeber); Knapp, David J. H. F. (Herausgeber); Ferry, Quentin R. V. (Herausgeber)
    Language: English
    Media type: Book
    Format: Print
    ISBN: 9781071606896; 1071606891
    RVK Categories: WD 5355
    Series: Methods in molecular biology ; 2162
    Subjects: Genetics; Biomedical engineering; RNA editing; CRISPR (Genetics); Genetics; Génétique; Génie biomédical; ARN; genetics; biomedical engineering; Genetics; Biomedical engineering; CRISPR (Genetics); RNA editing
    Scope: x, 286 Seiten, Illustrationen, 26 cm.
  2. Thegenetic age
    our perilous quest to edit life
    Author: Cobb, Matthew
    Published: 2023
    Publisher:  Profile books, London

    Location:
    Universitätsbibliothek Mannheim
    Signature:
    2023 A 2113
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    Source: Union catalogues
    Language: English
    Media type: Book
    Format: Print
    ISBN: 1788167015; 9781788167017
    Edition: paperback edition first published in 2023
    Subjects: Genetics; Genetics; Gene editing; CRISPR (Genetics); Génétique; Génétique - Histoire; Édition génique; CRISPR (Génétique); genetics
    Scope: 442 Seiten, Illustrationen, 20 cm
  3. Estimating intergenerational health transmission in Taiwan with administrative health records
    Author: Chang, Harrison; Halliday, Timothy; Lin, Ming-Jeng; Mazumder, Bhashkar
    Published: October 2023
    Publisher:  IZA - Institute of Labor Economics, Bonn, Germany

    We use population-wide administrative health records from Taiwan to estimate intergenerational persistence in health, providing the first estimates for a middle income country. We measure latent health by applying principal components analysis to a... more

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    We use population-wide administrative health records from Taiwan to estimate intergenerational persistence in health, providing the first estimates for a middle income country. We measure latent health by applying principal components analysis to a set of indicators for 13 broad ICD categories and quintiles of visits to a general practitioner. We find that the rank-rank slope in health between adult children and their parents is 0.22 which is broadly in line with results from other countries. Maternal transmission is stronger than paternal transmission and sons have higher persistence than daughters. Persistence is also higher at the upper tail of the parent health distribution. Persistence is lower when using inpatient data or when using total medical expenses and may overstate mobility. Health transmission is almost entirely unrelated to household income levels in Taiwan. We also find that that there are small geographic differences in health persistence across townships and that these are modestly correlated with area level income and doctor availability. Finally, by looking at persistence within health conditions that vary in their genetic component, we find little evidence that health persistence is driven by genetic factors.

     
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    Source: Union catalogues
    Language: English
    Media type: Book
    Format: Online
    Other identifier:
    hdl: 10419/282670
    Series: Discussion paper series / IZA ; no. 16543
    Subjects: intergenerational mobility; health; administrative data; genetics
    Scope: 1 Online-Ressource (circa 50 Seiten), Illustrationen
  4. Genetic susceptibility to depression and the role of partnership status
    Author: Gueltzow, Maria; Lahtinen, Hannu; Bijlsma, Maarten J.; Myrskylä, Mikko; Martikainen, Pekka
    Published: [2023]
    Publisher:  Max Planck Institute for Demographic Research, Rostock, Germany

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    Language: English
    Media type: Book
    Format: Online
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    Edition: Revised November 2023
    Series: MPIDR working paper ; WP 2023, 049 (November 2023)
    Subjects: Finland; genetics; marital status; mental health
    Scope: 1 Online-Ressource (circa 33 Seiten), Illustrationen
  5. The heritability of economic preferences
    Author: Kettlewell, Nathan; Tymula, Agnieszka; Yoo, Hong Il
    Published: November 2023
    Publisher:  IZA - Institute of Labor Economics, Bonn, Germany

    We study the heritability of risk, uncertainty, and time preferences using a field experiment with a large sample of adult twins. We also offer a meta-analysis of existing findings. Our field study introduces a novel empirical approach that marries... more

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    We study the heritability of risk, uncertainty, and time preferences using a field experiment with a large sample of adult twins. We also offer a meta-analysis of existing findings. Our field study introduces a novel empirical approach that marries behavioral genetics with structural econometrics. This allows us to, for the first time, quantify the heritability of economic preference parameters directly without employing proxy measures. Our incentive-compatible experiment is the first twin study to elicit all three types of preferences for the same individual. Compared to previous studies, we find a greater role of genes in explaining risk and uncertainty preferences, and of the shared familial environment in explaining time preferences. Time preferences appear more important from policy and parenting perspectives since they exhibit limited genetic variation and are more than twice as sensitive to the familial environment as risk and uncertainty preferences.

     
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    Source: Union catalogues
    Language: English
    Media type: Book
    Format: Online
    Other identifier:
    hdl: 10419/282760
    Series: Discussion paper series / IZA ; no. 16633
    Subjects: risk preferences; ambiguity aversion; time preferences; twin study; genetics
    Scope: 1 Online-Ressource (circa 72 Seiten), Illustrationen
  6. Genetic and socioeconomic achievement gaps in elementary school
    Author: Houmark, Mikkel Aagaard; Ronda, Victor; Agerbo, Esben; Mortensen, Preben Bo; Rosholm, Michael
    Published: July 2022
    Publisher:  IZA - Institute of Labor Economics, Bonn, Germany

    Socioeconomic (SES) gaps in academic achievement are well documented. We show that a very similar gap exists with respect to genetic differences measured by a polygenic score (PGS) for educational attainment. The genetic gap increases during... more

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    Socioeconomic (SES) gaps in academic achievement are well documented. We show that a very similar gap exists with respect to genetic differences measured by a polygenic score (PGS) for educational attainment. The genetic gap increases during elementary school, but only among the low SES children. Consequently, the high PGS children experience the largest achievement growth over the school years, even if they are born in socioeconomic disadvantage. While the SES gaps are partly due to selection into different environments, the high PGS children are simply better at extracting resources from a given environment because of higher conscientiousness and other predispositions.

     
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    Source: Union catalogues
    Language: English
    Media type: Book
    Format: Online
    Other identifier:
    hdl: 10419/263634
    Series: Discussion paper series / IZA ; no. 15418
    Subjects: child development; academic achievement; genetics; ses gaps; elementary schools; public investments; iPSYCH
    Scope: 1 Online-Ressource (circa 42 Seiten), Illustrationen
  7. Intergenerational transmission of time preferences
    an evidence from rural Thailand
    Author: Suparee Boonmanunt; Wasinee Jantorn; Varunee Khruapradit; Kilenthong, Weerachart T.
    Published: [2022]
    Publisher:  [Puey Ungphakorn Institute for Economic Research], [Bangkok]

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    Series: Discussion paper / Puey Ungphakorn Institute for Economic Research ; no. 178 (May 2022)
    Subjects: time preferences; field experiment; intergenerational transmission; skill formation; genetics
    Scope: 1 Online-Ressource (circa 39 Seiten), Illustrationen
  8. Understanding sibling correlations in education
    molecular genetics and family background
    Author: Fletcher, Jason; Lu, Qiongshi; Mazumder, Bhashkar; Song, Jie
    Published: January 2023
    Publisher:  IZA - Institute of Labor Economics, Bonn, Germany

    Sibling correlations in socioeconomic status are one of the key measures of equality of opportunity and social mobility, providing an omnibus examination of the importance of family background. Typically, these correlations are interpreted as the... more

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    Sibling correlations in socioeconomic status are one of the key measures of equality of opportunity and social mobility, providing an omnibus examination of the importance of family background. Typically, these correlations are interpreted as the combined effects of shared sibling background and experiences, including genetics and family environments. The UK Biobank allows us to specifically control for sibling and parental genetics (polygenic scores, PGS) in order to gauge their relative importance compared with broader family background effects. We use >17,000 sibling pairs from the UK Biobank in order to further decompose standard sibling correlations of educational attainment found in the literature. In general, we find modest (up to 20%) contributions of molecular genetics to the similarity of sibling outcomes, suggesting a large amount of the observed similarity in sibling educational outcomes are due to parents and environments of children.

     
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    Language: English
    Media type: Book
    Format: Online
    Other identifier:
    hdl: 10419/272489
    Series: Discussion paper series / IZA ; no. 15862
    Subjects: sibling correlations; educational mobility; genetics
    Scope: 1 Online-Ressource (circa 19 Seiten)
  9. Gene-environment effects on female fertility
    Author: Barban, Nicola; De Cao, Elisabetta; Francesconi, Marco
    Published: October 2021
    Publisher:  CESifo, Center for Economic Studies & Ifo Institute, Munich, Germany

    Fertility has a strong biological component generally ignored by economists. Using the UK Biobank, we analyze the extent to which genes, proxied by polygenic scores, and the environment, proxied by early exposure to the contraceptive pill diffusion,... more

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    Fertility has a strong biological component generally ignored by economists. Using the UK Biobank, we analyze the extent to which genes, proxied by polygenic scores, and the environment, proxied by early exposure to the contraceptive pill diffusion, affect age at first sexual intercourse, age at first birth, completed family size, and childlessness. Both genes and environment exert substantial influences on all outcomes. The anticipation of sexual debut and the postponement of motherhood led by the diffusion of the pill are magnified by gene-environment interactions, while the decline in family size and the rise in childlessness associated with female emancipation are attenuated by gene-environment effects. The nature-nurture interplay becomes stronger in more egalitarian environments that empower women, allowing genes to express themselves more fully. These conclusions are confirmed by heterogenous effects across the distributions of genetic susceptibilities and exposure to environmental risks, sister fixed effects models, mother-daughter comparisons, and counterfactual simulations.

     
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    Language: English
    Media type: Book
    Format: Online
    Other identifier:
    hdl: 10419/245518
    Series: CESifo working paper ; no. 9337 (2021)
    Subjects: fertility; genetics; polygenic score; contraceptive pill; nature versus nurture; social norms
    Scope: 1 Online-Ressource (circa 72 Seiten), Illustrationen
  10. The heritability of trust and trustworthiness depends on the measure of trust
    Author: Kettlewell, Nathan; Tymula, Agnieszka
    Published: September 2021
    Publisher:  IZA - Institute of Labor Economics, Bonn, Germany

    Using a large sample of 1,120 twins, we estimated the heritability of trust using four distinct measures of trust - domain-specific political trust, general self-reported trust, and incentivized behavioral trust and trustworthiness. Our results... more

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    Using a large sample of 1,120 twins, we estimated the heritability of trust using four distinct measures of trust - domain-specific political trust, general self-reported trust, and incentivized behavioral trust and trustworthiness. Our results highlight the importance of measuring trust in a context because its heritability differs substantially across the four measures, from 0% to 37%. Moreover, we provide the first evidence on the heritability of political trust which we estimate to be 37%. Furthermore, like the heritability, the environmental correlates of trust also vary across the different measures with political trust having the largest set of environmental covariates. The perceptions of COVID-19 health and income risks are among the unique correlates of political trust, with participants who are more worried about financial and health consequences of COVID-19, trusting politicians less, stressing the importance of trust in political leaders during a health crisis.

     
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    Source: Union catalogues
    Language: English
    Media type: Book
    Format: Online
    Other identifier:
    hdl: 10419/245785
    Series: Discussion paper series / IZA ; no. 14734
    Subjects: trust; heritability; genetics; twin study
    Scope: 1 Online-Ressource (circa 35 Seiten), Illustrationen
  11. Gene-environment effects on female fertility
    Author: Barban, Nicola; De Cao, Elisabetta; Francesconi, Marco
    Published: September 2021
    Publisher:  IZA - Institute of Labor Economics, Bonn, Germany

    Fertility has a strong biological component generally ignored by economists. Using the UK Biobank, we analyze the extent to which genes, proxied by polygenic scores, and the environment, proxied by early exposure to the contraceptive pill diffusion,... more

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    Fertility has a strong biological component generally ignored by economists. Using the UK Biobank, we analyze the extent to which genes, proxied by polygenic scores, and the environment, proxied by early exposure to the contraceptive pill diffusion, affect age at first sexual intercourse, age at first birth, completed family size, and childlessness. Both genes and environment exert substantial influences on all outcomes. The anticipation of sexual debut and the postponement of motherhood led by the diffusion of the pill are magnified by gene-environment interactions, while the decline in family size and the rise in childlessness associated with female emancipation are attenuated by gene-environment effects. The nature-nurture interplay becomes stronger in more egalitarian environments that empower women, allowing genes to express themselves more fully. These conclusions are confirmed by heterogenous effects across the distributions of genetic susceptibilities and exposure to environmental risks, sister fixed effects models, mother-daughter comparisons, and counterfactual simulations.

     
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    Source: Union catalogues
    Language: English
    Media type: Book
    Format: Online
    Other identifier:
    hdl: 10419/250417
    Series: Discussion paper series / IZA ; no. 14756
    Subjects: fertility; genetics; polygenic score; contraceptive pill; nature versus nurture; social norms
    Scope: 1 Online-Ressource (circa 72 Seiten), Illustrationen
  12. Moral hazard heterogeneity: genes and health insurance influence smoking after a health shock
    Author: Biroli, Pietro; Zwyssig, Laura
    Published: March 2021
    Publisher:  IZA - Institute of Labor Economics, Bonn, Germany

    Decision-making in the realm of health behaviors, such as smoking or drinking, is influenced both by biological factors, such as genetic predispositions, as well as environmental factors, such as financial liquidity and health insurance status. We... more

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    Decision-making in the realm of health behaviors, such as smoking or drinking, is influenced both by biological factors, such as genetic predispositions, as well as environmental factors, such as financial liquidity and health insurance status. We show how the choice of smoking after a cardio-vascular health shock is jointly determined by the interplay between these biological and environmental constraints. Individuals who suffer a health shock when uninsured are 25.6 percentage points more likely to reduce smoking, but this is true only for those who have a low index of genetic predisposition to smoking. Individuals with a low index of genetic predisposition are more strategic and flexible in their behavioral response to an external shock. This differential elasticity of response depending on your genetic variants is evidence of individual-level heterogeneity in moral hazard. These results suggest that genetic heterogeneity is a factor that should be considered when evaluating the effectiveness and fairness of health insurance policies.

     
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    Source: Union catalogues
    Language: English
    Media type: Book
    Format: Online
    Other identifier:
    hdl: 10419/236207
    Series: Discussion paper series / IZA ; no. 14176
    Subjects: moral hazard; genetics; smoking; medicare
    Scope: 1 Online-Ressource (circa 72 Seiten), Illustrationen
  13. Disparities in socio-economic status and BMI in the UK are partly due to genetic and environmental luck
    Author: Burik, Casper A. P.; Kweon, Hyeokmoon; Koellinger, Philipp
    Published: [2021]
    Publisher:  Tinbergen Institute, Amsterdam, The Netherlands

    Two family-specific lotteries take place during conception- a social lottery that determines who our parents are and which environment we grow up in, and a genetic lottery that determines which part of their genomes our parents pass on to us. The... more

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    Two family-specific lotteries take place during conception- a social lottery that determines who our parents are and which environment we grow up in, and a genetic lottery that determines which part of their genomes our parents pass on to us. The outcomes of these lotteries create inequalities of opportunity that can translate into disparities in health and socioeconomic status. Here, we estimate a lower bound for the relevance of these two lotteries for differences in education, income and body mass index in a sample of 38,698 siblings in the UK who were born between 1937 and 1970. Our estimates are based on models that combine family-specific effects with gene-by-environment interactions. We find that the random differences between siblings in their genetic endowments clearly contribute towards inequalities in the outcomes we study. Our rough proxy of the environment people grew up in, which we derived from their place of birth, are also predictive of the studied outcomes, but not beyond the relevance of family environment. Our estimates suggest that at least 13 to 17 percent of the inequalities in education, wages and BMI in the UK are due to inequalities in opportunity that arise from the outcomes of the social and the genetic lottery.

     
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    Source: Union catalogues
    Language: English
    Media type: Book
    Format: Online
    Other identifier:
    hdl: 10419/237768
    Series: Array ; TI 2021, 035
    Subjects: inequality; income; education; BMI; genetics; polygenic index
    Scope: 1 Online-Ressource (circa 31 Seiten), Illustrationen
  14. Integrating genetics into economics
    = Het integreren van genetica in de economie
    Author: Slob, Eric Arsène Willem
    Published: [2021]
    Publisher:  Erasmus Institute of Management (ERIM), Rotterdam

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    Language: English
    Media type: Dissertation
    Format: Online
    ISBN: 9789058925961
    Other identifier:
    hdl: 1765/135159
    Series: ERIM PhD series in research in management ; EPS-2021-517-S&E
    Subjects: Genoeconomics; genetics; economics; Mendelian randomization; smoking; polygenic risk score; entrepreneurship; heredity; Genoeconomie; genetica; economie; Mendeliaanse randomisatie; rookgedrag; polygenetische risico score; ondernemerschap; erfelijkheid
    Scope: 1 Online-Ressource (circa 192 Seiten), Illustrationen
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    Dissertation, Erasmus University Rotterdam, 2021
  15. Estimating intergenerational health transmission in Taiwan with administrative health records
    Author: Chang, Harrison; Halliday, Timothy; Lin, Ming-Jeng; Mazumder, Bhashkar
    Published: October 2023
    Publisher:  University of Hawai'i at Mānoa, Department of Economics, Honolulu, HI

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    Series: Working paper series / University of Hawai'i at Mānoa, Department of Economics ; no. 23, 08
    Subjects: intergenerational mobility; health; administrative data; genetics
    Scope: 1 Online-Ressource (circa 49 Seiten), Illustrationen