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  1. RNA editing
    Contributor: Göringer, Hans Ulrich (Publisher)
    Published: 2008
    Publisher:  Springer, Heidelberg

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    Source: Union catalogues
    Contributor: Göringer, Hans Ulrich (Publisher)
    Language: English
    Media type: Book
    Format: Print
    ISBN: 9783540737865; 3540737863
    Other identifier:
    9783540737865
    RVK Categories: WG 1800 ; WD 5355
    DDC Categories: 570
    Series: Nucleic acids and molecular biology ; 20
    Subjects: Biochemistry; Cell biology; Microbiology; Life Sciences; Biochemistry, general; Biological Techniques; Plant Biochemistry; RNA Editing
    Scope: XI, 231 S., Ill., graph. Darst., 24 cm
    Notes:

    Literaturangaben
  2. Adenosine Deaminases Acting on RNA (ADARs) and A-to-I Editing
    Author: Samuel, Charles E.
    Published: 2012
    Publisher:  Springer-Verlag Berlin Heidelberg, Berlin, Heidelberg

    The objective of this CTMI volume is to provide readers with a foundation for understanding what ADARs are and how they act to affect gene expression and function. Because A-to-I editing may affect base-pairing and RNA structure, processes including... more

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    Niedersächsische Staats- und Universitätsbibliothek Göttingen
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    The objective of this CTMI volume is to provide readers with a foundation for understanding what ADARs are and how they act to affect gene expression and function. Because A-to-I editing may affect base-pairing and RNA structure, processes including translation, splicing, RNA replication, and miR and siRNA silencing may be affected.¡ It also is becoming increasingly apparent that ADARs may possess roles not only as enzymes that deaminate adenosine to produce inosine in RNA substrates with double-stranded character, but also as proteins independent of their catalytic property. Future studies of ADARs no doubt will provide us with additional surprises and new insights into the modulation of biological processes by the ADAR family of proteins The objective of this "CTMI" volume is to provide readers with a foundation for understanding what ADARs are and how they act to affect gene expression and function. It is becoming increasingly apparent that ADARs may possess roles not only as enzymes that deaminate adenosine to produce inosine in RNA substrates with double-stranded character, but also as proteins independent of their catalytic property. Because A-to-I editing may affect base-pairing and RNA structure, processes including translation, splicing, RNA replication, and miR and siRNA silencing may be affected. Future stud

     
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    Source: Union catalogues
    Language: English
    Media type: Ebook
    Format: Online
    ISBN: 9783642228018
    Other identifier:
    RVK Categories: WD 5065
    Series: Current Topics in Microbiology and Immunology ; 353
    Subjects: Medicine; Human physiology; Adenosine Deaminase; RNA Editing; RNA, Double-Stranded
    Scope: Online-Ressource, v.: digital
    Notes:

    Description based upon print version of record

    Electronic reproduction; Available via World Wide Web

    Adenosine Deaminases Acting on RNA (ADARs) and A-to-I Editing; Preface; Contents; Contributors; 144 ADAR Proteins: Structure and Catalytic Mechanism; Abstract; 1…The Reaction Catalyzed by ADARs; 2…The ADAR Protein Structure is Modular; 3…Overview of Structure of ADAR2 Deaminase Domain; 4…H394, C451, C516: Zn2+ Binding; 4.1 E396; 4.2 T375; 4.3 R455; 5…Residues Involved in IP6 Binding; 6…Roles of Functional Groups in RNA Substrate at or Near the Deamination Site; 7…The Effect of Helix Defects; 8…Preferred Flanking Sequence; 9…A--C Mismatch at Editing Site

    10…2vprime-Hydroxyl of the Edited Nucleoside11…8-Aza Substitution at Edited Adenosine; 12…N7 of Substrate, C7 Substituents on Adenosine Analogs; 13…C6- and C2-Positions of the Edited Purine; 13.1 The ADAR Reaction Mechanism; 13.2 Dimerization; 13.3 Substrate Binding and Conformational Changes; 13.4 Deamination in the ADAR Active Site and Product Release; Acknowledgments; References; 145 ADAR Proteins: Double-stranded RNA and Z-DNA Binding Domains; Abstract; 1…Introduction; 2…Adenosine Deaminases Acting on RNA Family Members and Their Domain Organization; 3…RNA Editing Substrate

    3.1 Specificity of Editing3.2 What Makes a Good Editing Site?; 3.2.1 Preferences; 3.2.2 Selectivity; 3.3 Structures of Editing Substrates; 4…Adenosine Deaminases Acting on RNA Z-DNA Binding Domains; 4.1 Z-DNA Binding Domain: Structure and Substrate Recognition; 4.2 A Role for ADAR1 Z alpha Domain?; 4.3 How Does a Z-DNA Binding Domain Bind to Z-DNA?; 4.4 ADAR1 Z beta Domain: a Domain for Protein--Protein Interaction?; 5…Adenosine Deaminases Acting on RNA dsRNA Binding Domains; 5.1 Structural Characteristics of a dsRNA Binding Domain; 5.2 Sequence Specific Recognition with dsRBD

    5.3 How dsRBDs are Positioned on Substrate?5.4 Are the Binding Sites of ADAR dsRBDs Predictable?; 6…dsRBDs and Z-DNA Binding Domains Act on the Subcellular Localization of ADARs; 7…Concluding Remarks; Acknowledgments; References; 157 Editing of Neurotransmitter Receptor and Ion Channel RNAs in the Nervous System; Abstract; 1…Introduction; 2…Identification of A-to-I Editing Targets; 3…Mammalian ADAR Enzymes; 4…ADAR Substrates in the Central Nervous System; 4.1 Glutamate-Gated Ion Channels; 4.1.1 AMPA Receptors; 4.1.2 Kainate Receptors; 4.2 The Serotonin 2C Receptor (5HT2C)

    4.3 The alpha 3 Subunit of the GABAA Receptor (Gabra3)4.4 Voltage-gated Potassium Channel (Kv1.1); 5…Conclusions; References; 151 Modulation of MicroRNA Expression and Function by ADARs; Abstract; 1…Introduction; 2…MiRNA Biogenesis and Function; 3…Editing of MiRNAs; 3.1 Identification of Pri-MiRNA Editing Sites; 3.1.1 Systematic Surveys for MiRNA Editing Sites; 3.1.2 High-Throughput Sequencing of Mature MiRNAs; 3.2 Consequences of Pri-MiRNA Editing; 3.2.1 Effect on Drosha Cleavage; 3.2.2 Degradation of Inosine-Containing Pri-MiRNAs; 3.2.3 Effect on Dicer Cleavage; 3.2.4 Effect on RISC Loading

    3.2.5 Effect on Mature MiRNA Function
  3. Modification and editing of RNA
    Published: ©1998
    Publisher:  ASM Press, Washington, DC

    Historical perspectives on RNA nucleoside modifications-- RNA-modifying and RNA-editing enzymes: methods for their identification-- Detection and structure analysis of modified nucleosides in RNA by mass spectrometry-- Incorporation of modified... more

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    Historical perspectives on RNA nucleoside modifications-- RNA-modifying and RNA-editing enzymes: methods for their identification-- Detection and structure analysis of modified nucleosides in RNA by mass spectrometry-- Incorporation of modified nucleotides into RNA for studies on RNA structure, function, and intermolecular interactions-- Biophysical and conformational properties of modified nucleosides in RNA (nuclear magnetic resonance studies)-- Effects of pseudouridylation on tRNA hydration and dynamics: a theoretical approach. Modulation role of modified nucleotides in RNA loop-loop interaction-- Mechanisms of RNA-modifying and -editing enzymes-- Structural basis of base exchange by tRNA guanine transglycosylases-- Biosynthesis and functions of modified nucleosides in eukaryotic mRNA-- Posttranscriptional modifications in the U small nuclear RNAs-- The pseudouridine residues of rRNA: number, location, biosynthesis, and function-- Small nucleolar RNAs guide the ribose methylations of eukaryotic rRNAs-- Fuctional aspects of the three modified nucleotides in yeast mitochondrial large-subunit rRNA. Regulatory aspects of rRNA modifications and pre-tRNA processing-- Editing of tRNA-- RNA editing by base conversion in plant organellar RNAs-- Apolipoprotein B mRNA editing-- Adenosine-to-inosine conversion in mRNA-- Nucleoside deaminases for cytidine and adenosine: comparison with deaminases acting on RNA-- Mitochondrial mRNA editing in kinetoplastid protozoa-- RNA editing in physarum mitochondria-- Contrascriptional paramyxovirus mRNA editing: a contradiction in trems?-- Intracellular locations of RNA-modifying enzymes. Genetics and regulation of base modification in the tRNA and rRNA of prokaryotes and eukaryotes-- Links between tRNA modification and metabolism and modified nucleosides as tumor markers-- Modified nucleosides in translation-- Importance of modified nucleotides in replication of retroviruses, plant pararetroviruses, and retrotransposons-- Modified nucleotides always were: an evolutionary model-- Chemical structures and classification of postranscriptionally modified nucleosides in RNA-- RNA editing types and characteristics. General properties of RNA-modifying and -editing enzymes-- Location and distribution of modified nucleotides in tRNA-- Modified nucleosides at positions 34 and 37 of tRNAs and their predicted coding capacities. This Comprehensive, current text explores the manifold ways in which living cells respond to genomic injury and alterations, including both spontaneous and environmentally induced DNA damage. With more than 4,000 complete references to primary research literature and over 380 color figures throughout, this book is an important text for all courses in DNA repair and mutagenesis. It will also serve as a major reference for all molecular biologists working in cancer biology, recombination, transcription and gene regulation, DNA replication, environmental studies, and biological evolution

     
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    Source: Union catalogues
    Language: English
    Media type: Ebook
    Format: Online
    ISBN: 9781683672685; 1683672682
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    Subjects: RNA editing; RNA Editing; RNA Processing, Post-Transcriptional; 35.73 molecular genetics; RNA editing; RNS-Edierung; Aufsatzsammlung; RNA; Transcriptie (biochemie); Régulation génétique; ARN ; Édition; RNS
    Scope: 1 Online-Ressource (xiii, 596 pages), illustrations
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    Includes bibliographical references and index
  4. Modification and editing of RNA
    Published: 1998
    Publisher:  ASM Press, Washington, D.C.

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    Universitätsbibliothek Bayreuth
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    Source: Union catalogues
    Language: English
    Media type: Book
    ISBN: 1555811337
    RVK Categories: WD 5355 ; WG 1800
    Subjects: ARN - Édition; RNA; Régulation génétique; Transcriptie (biochemie); RNA Editing; RNA Processing, Post-Transcriptional; RNA editing; RNS; RNS-Edierung
    Scope: XIII, 596 S., Ill., graph. Darst.
  5. RNA and DNA editing
    molecular mechanisms and their integration into biological systems
    Published: 2008
    Publisher:  Wiley-Interscience, Hoboken, N.J.

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    Language: English
    Media type: Ebook
    Format: Online
    ISBN: 9780470262252; 0470262257; 9780470262269; 0470262265; 1281237531; 9781281237538
    Subjects: RNA Editing; Base Sequence; Genomics; Transcription, Genetic; SCIENCE / Life Sciences / Molecular Biology; DNA.; Genetic transcription; Nucleotide sequence; RNA editing; Array; Transkription <Genetik>; RNS-Edierung
    Scope: 1 online resource (xxiii, 426 pages, [12] pages of plates), illustrations (some color)
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    Print version record

    Latest discoveries in RNA and DNA editing research, with expert forecasts of the field's future directions. RNA and DNA Editing assembles a team of leading experts who present the latestdiscoveries in the field alongside the latest models and met
  6. RNA and DNA editing
    molecular mechanisms and their integration into biological systems
    Published: ©2008
    Publisher:  Wiley-Interscience, Hoboken, N.J.

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    Technische Hochschulbibliothek Rosenheim
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    ISBN: 9780470262252; 0470262257; 9780470262269; 0470262265; 1281237531; 9781281237538
    Other identifier:
    RVK Categories: WD 5355 ; WG 1700 ; WG 1800
    Subjects: RNA Editing; Base Sequence; Genomics; Transcription, Genetic; SCIENCE / Life Sciences / Molecular Biology; DNA.; Genetic transcription; Nucleotide sequence; RNA editing; RNA editing; DNA.; Nucleotide sequence; Genetic transcription; RNS-Edierung; Transkription <Genetik>
    Scope: 1 Online-Ressource (xxiii, 426 pages, [12] pages of plates)
    Notes:

    Includes bibliographical references and index

    Latest discoveries in RNA and DNA editing research, with expert forecasts of the field's future directions. RNA and DNA Editing assembles a team of leading experts who present the latestdiscoveries in the field alongside the latest models and met
  7. RNA and DNA editing
    molecular mechanisms and their integration into biological systems
    Published: c2008
    Publisher:  Wiley-Interscience, Hoboken, N.J.

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    Ostbayerische Technische Hochschule Amberg-Weiden / Hochschulbibliothek Amberg
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    ISBN: 0470262257; 9780470262252
    Subjects: SCIENCE / Life Sciences / Molecular Biology; DNA.; Genetic transcription; Nucleotide sequence; RNA editing; RNA Editing; Base Sequence; Genomics; Transcription, Genetic; RNA editing; DNA.; Nucleotide sequence; Genetic transcription; Transkription <Genetik>; RNS-Edierung
    Scope: 1 Online-Ressource (xxiii, 426 p., [12] p. of plates)
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    Includes bibliographical references and index
  8. RNA interference, editing, and modification
    methods and protocols
    Published: 2004
    Publisher:  Humana Press, Totowa, NJ

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    Universitätsbibliothek Bayreuth
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  9. Fine-tuning of RNA functions by modification and editing
    Published: c 2005
    Publisher:  Springer, Berlin [u.a.]

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    Universitäts- und Landesbibliothek Sachsen-Anhalt / Zentrale
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    LS 42.13/2005:0422
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    Source: Union catalogues
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    Format: Print
    ISBN: 3540244956; 9783540244950
    RVK Categories: WD 5355
    Series: Topics in current genetics ; 12
    Subjects: RNA editing; RNA Processing, Post-Transcriptional; Nucleosides; RNA; RNA Editing
    Scope: XXIV, 442 S, Ill., graph. Darst
  10. RNA and DNA editing
    molecular mechanisms and their integration into biological systems
    Published: 2008
    Publisher:  Wiley-Interscience, Hoboken, N.J.

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    Universitätsbibliothek Bayreuth
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    ISBN: 9780470109915
    RVK Categories: WD 5355 ; WG 1700 ; WG 1800
    Subjects: Base Sequence; DNA; Genetic transcription; Genomics; Nucleotide sequence; RNA Editing; RNA editing; Transcription, Genetic; Transkription <Genetik>; RNS-Edierung
    Scope: XXIII, 426 S., Ill., graph. Darst.
    Notes:

    Includes bibliographical references and index
  11. Adenosine Deaminases Acting on RNA (ADARs) and A-to-I Editing
    Author: Samuel, Charles E.
    Published: 2012
    Publisher:  Springer-Verlag Berlin Heidelberg, Berlin, Heidelberg

    The objective of this CTMI volume is to provide readers with a foundation for understanding what ADARs are and how they act to affect gene expression and function. Because A-to-I editing may affect base-pairing and RNA structure, processes including... more

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    Universität Potsdam, Universitätsbibliothek
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    Unlimited inter-library loan, copies and loan

     

    The objective of this CTMI volume is to provide readers with a foundation for understanding what ADARs are and how they act to affect gene expression and function. Because A-to-I editing may affect base-pairing and RNA structure, processes including translation, splicing, RNA replication, and miR and siRNA silencing may be affected.¡ It also is becoming increasingly apparent that ADARs may possess roles not only as enzymes that deaminate adenosine to produce inosine in RNA substrates with double-stranded character, but also as proteins independent of their catalytic property. Future studies of ADARs no doubt will provide us with additional surprises and new insights into the modulation of biological processes by the ADAR family of proteins The objective of this "CTMI" volume is to provide readers with a foundation for understanding what ADARs are and how they act to affect gene expression and function. It is becoming increasingly apparent that ADARs may possess roles not only as enzymes that deaminate adenosine to produce inosine in RNA substrates with double-stranded character, but also as proteins independent of their catalytic property. Because A-to-I editing may affect base-pairing and RNA structure, processes including translation, splicing, RNA replication, and miR and siRNA silencing may be affected. Future stud

     
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    Source: Union catalogues
    Language: English
    Media type: Ebook
    Format: Online
    ISBN: 9783642228018
    Other identifier:
    RVK Categories: WD 5065
    Series: Current Topics in Microbiology and Immunology ; 353
    Subjects: Medicine; Human physiology; Adenosine Deaminase; RNA Editing; RNA, Double-Stranded
    Scope: Online-Ressource, v.: digital
    Notes:

    Description based upon print version of record

    Electronic reproduction; Available via World Wide Web

    Adenosine Deaminases Acting on RNA (ADARs) and A-to-I Editing; Preface; Contents; Contributors; 144 ADAR Proteins: Structure and Catalytic Mechanism; Abstract; 1…The Reaction Catalyzed by ADARs; 2…The ADAR Protein Structure is Modular; 3…Overview of Structure of ADAR2 Deaminase Domain; 4…H394, C451, C516: Zn2+ Binding; 4.1 E396; 4.2 T375; 4.3 R455; 5…Residues Involved in IP6 Binding; 6…Roles of Functional Groups in RNA Substrate at or Near the Deamination Site; 7…The Effect of Helix Defects; 8…Preferred Flanking Sequence; 9…A--C Mismatch at Editing Site

    10…2vprime-Hydroxyl of the Edited Nucleoside11…8-Aza Substitution at Edited Adenosine; 12…N7 of Substrate, C7 Substituents on Adenosine Analogs; 13…C6- and C2-Positions of the Edited Purine; 13.1 The ADAR Reaction Mechanism; 13.2 Dimerization; 13.3 Substrate Binding and Conformational Changes; 13.4 Deamination in the ADAR Active Site and Product Release; Acknowledgments; References; 145 ADAR Proteins: Double-stranded RNA and Z-DNA Binding Domains; Abstract; 1…Introduction; 2…Adenosine Deaminases Acting on RNA Family Members and Their Domain Organization; 3…RNA Editing Substrate

    3.1 Specificity of Editing3.2 What Makes a Good Editing Site?; 3.2.1 Preferences; 3.2.2 Selectivity; 3.3 Structures of Editing Substrates; 4…Adenosine Deaminases Acting on RNA Z-DNA Binding Domains; 4.1 Z-DNA Binding Domain: Structure and Substrate Recognition; 4.2 A Role for ADAR1 Z alpha Domain?; 4.3 How Does a Z-DNA Binding Domain Bind to Z-DNA?; 4.4 ADAR1 Z beta Domain: a Domain for Protein--Protein Interaction?; 5…Adenosine Deaminases Acting on RNA dsRNA Binding Domains; 5.1 Structural Characteristics of a dsRNA Binding Domain; 5.2 Sequence Specific Recognition with dsRBD

    5.3 How dsRBDs are Positioned on Substrate?5.4 Are the Binding Sites of ADAR dsRBDs Predictable?; 6…dsRBDs and Z-DNA Binding Domains Act on the Subcellular Localization of ADARs; 7…Concluding Remarks; Acknowledgments; References; 157 Editing of Neurotransmitter Receptor and Ion Channel RNAs in the Nervous System; Abstract; 1…Introduction; 2…Identification of A-to-I Editing Targets; 3…Mammalian ADAR Enzymes; 4…ADAR Substrates in the Central Nervous System; 4.1 Glutamate-Gated Ion Channels; 4.1.1 AMPA Receptors; 4.1.2 Kainate Receptors; 4.2 The Serotonin 2C Receptor (5HT2C)

    4.3 The alpha 3 Subunit of the GABAA Receptor (Gabra3)4.4 Voltage-gated Potassium Channel (Kv1.1); 5…Conclusions; References; 151 Modulation of MicroRNA Expression and Function by ADARs; Abstract; 1…Introduction; 2…MiRNA Biogenesis and Function; 3…Editing of MiRNAs; 3.1 Identification of Pri-MiRNA Editing Sites; 3.1.1 Systematic Surveys for MiRNA Editing Sites; 3.1.2 High-Throughput Sequencing of Mature MiRNAs; 3.2 Consequences of Pri-MiRNA Editing; 3.2.1 Effect on Drosha Cleavage; 3.2.2 Degradation of Inosine-Containing Pri-MiRNAs; 3.2.3 Effect on Dicer Cleavage; 3.2.4 Effect on RISC Loading

    3.2.5 Effect on Mature MiRNA Function
  12. RNA Editing
    Author: Göringer, H. Ulrich
    Published: 2008
    Publisher:  Springer-Verlag Berlin Heidelberg, Berlin, Heidelberg

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    Universität Potsdam, Universitätsbibliothek
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    Volltext (lizenzpflichtig)
    Source: Union catalogues
    Language: English
    Media type: Ebook
    Format: Online
    ISBN: 9783540737872
    Other identifier:
    Series: Nucleic Acids and Molecular Biology ; 20
    Subjects: Life Sciences; Biochemistry; Microbiology; Cytology; Cytology; RNA Editing
    Scope: Online-Ressource, v.: digital
    Notes:

    Includes bibliographical references and index

    Electronic reproduction; Available via World Wide Web
  13. RNA and DNA editing
    molecular mechanisms and their integration into biological systems
    Published: 2008
    Publisher:  Wiley-Interscience, Hoboken, N.J.

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    Humboldt-Universität zu Berlin, Universitätsbibliothek, Jacob-und-Wilhelm-Grimm-Zentrum
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    Source: Union catalogues
    Language: English
    Media type: Book
    ISBN: 9780470109915
    RVK Categories: WD 5355 ; WG 1700 ; WG 1800
    Subjects: Base Sequence; DNA; Genetic transcription; Genomics; Nucleotide sequence; RNA Editing; RNA editing; Transcription, Genetic; Transkription <Genetik>; RNS-Edierung
    Scope: XXIII, 426 S., Ill., graph. Darst.
    Notes:

    Includes bibliographical references and index
  14. RNA Editing
    Published: 2008
    Publisher:  Springer-Verlag Berlin Heidelberg, Berlin, Heidelberg

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    Universitätsbibliothek Greifswald
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    Technische Universität Hamburg, Universitätsbibliothek
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    Bibliotheks-und Informationssystem der Carl von Ossietzky Universität Oldenburg (BIS)
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    Format: Online
    ISBN: 9783540737872
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    RVK Categories: WG 1800-WG 1840 ; WG 1800
    Series: Nucleic Acids and Molecular Biology ; 20
    Array
    Subjects: Life sciences; Biochemistry; Cytology; Microbiology; Cytology; Life Sciences; Life Sciences; Biochemistry; Microbiology; Cytology; Cytology; RNA Editing; Biochemistry; Biochemistry, general; Biological Techniques; Cell biology; Life Sciences; Microbiology; Plant Biochemistry; RNA Editing
    Scope: Online-Ressource (XI, 231 p, digital)
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    Includes bibliographical references and index
  15. RNA modification
    Contributor: Gott, Jonatha M. (Hrsg.)
    Published: 2007
    Publisher:  Elsevier, Amsterdam

    The presence of modified nucleotides in cellular RNAs has been known for decades and over 100 distinct RNA modifications have been characterized to date. While the exact role of many of these modifications is still unclear, many are highly conserved... more

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    Technische Universität Bergakademie Freiberg, Bibliothek 'Georgius Agricola'
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    The presence of modified nucleotides in cellular RNAs has been known for decades and over 100 distinct RNA modifications have been characterized to date. While the exact role of many of these modifications is still unclear, many are highly conserved across evolution and most contribute to the overall fitness of the organism. In recent years, new methods and bioinformatics approaches have been developed for the dissection of modification pathways and functions. These methods intersect a number of related fields, ranging from RNA processing to comparative genomics and systems biology. In addition, many of the techniques described in this volume have broad applicability, particularly in regards to the isolation, characterization, and reconstitution of ribonucleoprotein complexes, expanding the experimental repertoire available to all RNA researchers

     
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    Source: Union catalogues
    Contributor: Gott, Jonatha M. (Hrsg.)
    Language: English
    Media type: Ebook
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    ISBN: 0123741556
    RVK Categories: WC 4355 ; WC 4460
    Edition: Online-Ausg.
    Series: Methods in enzymology ; 425
    Methods in enzymology 0076-6879 ; v. 425
    Subjects: RNA editing; RNA Editing; RNA editing
    Scope: Online-Ressource, illustrations.
    Notes:

    Includes bibliographical references and indexes. - Print version record
  16. Adenosine Deaminases Acting on RNA (ADARs) and A-to-I Editing
    Author: Samuel, Charles E.
    Published: 2012
    Publisher:  Springer-Verlag Berlin Heidelberg, Berlin, Heidelberg

    The objective of this CTMI volume is to provide readers with a foundation for understanding what ADARs are and how they act to affect gene expression and function. Because A-to-I editing may affect base-pairing and RNA structure, processes including... more

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    The objective of this CTMI volume is to provide readers with a foundation for understanding what ADARs are and how they act to affect gene expression and function. Because A-to-I editing may affect base-pairing and RNA structure, processes including translation, splicing, RNA replication, and miR and siRNA silencing may be affected.¡ It also is becoming increasingly apparent that ADARs may possess roles not only as enzymes that deaminate adenosine to produce inosine in RNA substrates with double-stranded character, but also as proteins independent of their catalytic property. Future studies of ADARs no doubt will provide us with additional surprises and new insights into the modulation of biological processes by the ADAR family of proteins The objective of this "CTMI" volume is to provide readers with a foundation for understanding what ADARs are and how they act to affect gene expression and function. It is becoming increasingly apparent that ADARs may possess roles not only as enzymes that deaminate adenosine to produce inosine in RNA substrates with double-stranded character, but also as proteins independent of their catalytic property. Because A-to-I editing may affect base-pairing and RNA structure, processes including translation, splicing, RNA replication, and miR and siRNA silencing may be affected. Future stud

     
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    Volltext (lizenzpflichtig)
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    Language: English
    Media type: Ebook
    Format: Online
    ISBN: 9783642228018
    Other identifier:
    RVK Categories: WD 5065
    Series: Current Topics in Microbiology and Immunology ; 353
    Array
    Subjects: Medicine; Human physiology; Biomedicine; Medicine; Human physiology; Adenosine Deaminase; RNA Editing; RNA, Double-Stranded
    Other subjects: Double-stranded RNA; Adenosine deaminase
    Scope: Online-Ressource (X, 238p. 50 illus., 28 illus. in color, digital)
    Notes:

    Description based upon print version of record

    Adenosine Deaminases Acting on RNA (ADARs) and A-to-I Editing; Preface; Contents; Contributors; 144 ADAR Proteins: Structure and Catalytic Mechanism; Abstract; 1…The Reaction Catalyzed by ADARs; 2…The ADAR Protein Structure is Modular; 3…Overview of Structure of ADAR2 Deaminase Domain; 4…H394, C451, C516: Zn2+ Binding; 4.1 E396; 4.2 T375; 4.3 R455; 5…Residues Involved in IP6 Binding; 6…Roles of Functional Groups in RNA Substrate at or Near the Deamination Site; 7…The Effect of Helix Defects; 8…Preferred Flanking Sequence; 9…A--C Mismatch at Editing Site

    10…2vprime-Hydroxyl of the Edited Nucleoside11…8-Aza Substitution at Edited Adenosine; 12…N7 of Substrate, C7 Substituents on Adenosine Analogs; 13…C6- and C2-Positions of the Edited Purine; 13.1 The ADAR Reaction Mechanism; 13.2 Dimerization; 13.3 Substrate Binding and Conformational Changes; 13.4 Deamination in the ADAR Active Site and Product Release; Acknowledgments; References; 145 ADAR Proteins: Double-stranded RNA and Z-DNA Binding Domains; Abstract; 1…Introduction; 2…Adenosine Deaminases Acting on RNA Family Members and Their Domain Organization; 3…RNA Editing Substrate

    3.1 Specificity of Editing3.2 What Makes a Good Editing Site?; 3.2.1 Preferences; 3.2.2 Selectivity; 3.3 Structures of Editing Substrates; 4…Adenosine Deaminases Acting on RNA Z-DNA Binding Domains; 4.1 Z-DNA Binding Domain: Structure and Substrate Recognition; 4.2 A Role for ADAR1 Z alpha Domain?; 4.3 How Does a Z-DNA Binding Domain Bind to Z-DNA?; 4.4 ADAR1 Z beta Domain: a Domain for Protein--Protein Interaction?; 5…Adenosine Deaminases Acting on RNA dsRNA Binding Domains; 5.1 Structural Characteristics of a dsRNA Binding Domain; 5.2 Sequence Specific Recognition with dsRBD

    5.3 How dsRBDs are Positioned on Substrate?5.4 Are the Binding Sites of ADAR dsRBDs Predictable?; 6…dsRBDs and Z-DNA Binding Domains Act on the Subcellular Localization of ADARs; 7…Concluding Remarks; Acknowledgments; References; 157 Editing of Neurotransmitter Receptor and Ion Channel RNAs in the Nervous System; Abstract; 1…Introduction; 2…Identification of A-to-I Editing Targets; 3…Mammalian ADAR Enzymes; 4…ADAR Substrates in the Central Nervous System; 4.1 Glutamate-Gated Ion Channels; 4.1.1 AMPA Receptors; 4.1.2 Kainate Receptors; 4.2 The Serotonin 2C Receptor (5HT2C)

    4.3 The alpha 3 Subunit of the GABAA Receptor (Gabra3)4.4 Voltage-gated Potassium Channel (Kv1.1); 5…Conclusions; References; 151 Modulation of MicroRNA Expression and Function by ADARs; Abstract; 1…Introduction; 2…MiRNA Biogenesis and Function; 3…Editing of MiRNAs; 3.1 Identification of Pri-MiRNA Editing Sites; 3.1.1 Systematic Surveys for MiRNA Editing Sites; 3.1.2 High-Throughput Sequencing of Mature MiRNAs; 3.2 Consequences of Pri-MiRNA Editing; 3.2.1 Effect on Drosha Cleavage; 3.2.2 Degradation of Inosine-Containing Pri-MiRNAs; 3.2.3 Effect on Dicer Cleavage; 3.2.4 Effect on RISC Loading

    3.2.5 Effect on Mature MiRNA Function
  17. RNA interference, editing, and modification
    methods and protocols
    Contributor: Gott, Jonatha M. (Hrsg.)
    Published: c 2004
    Publisher:  Humana Press, Totowa, NJ

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    ISBN: 1588292428
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    2003020827
    1-59259-775-0
    RVK Categories: WC 4150 ; WC 4460
    Series: Methods in molecular biology ; 265
    Subjects: RNA editing; RNA editing; RNA Editing; RNA Interference; RNA Editing; RNA Interference
    Scope: XIII, 435 S, Ill., graph. Darst, 24 cm
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    Includes bibliographical references and index
  18. RNA Editing
    Author: Göringer, H. Ulrich
    Published: 2008
    Publisher:  Springer-Verlag Berlin Heidelberg, Berlin, Heidelberg

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    ISBN: 9783540737872
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    Series: Nucleic Acids and Molecular Biology ; 20
    Subjects: Life Sciences; Biochemistry; Microbiology; Cytology; Cytology; RNA Editing
    Scope: Online-Ressource, v.: digital
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    Includes bibliographical references and index

    Electronic reproduction; Available via World Wide Web
  19. RNA interference, editing, and modification
    methods and protocols
    Contributor: Gott, Jonatha M. (Hrsg.)
    Published: c 2004
    Publisher:  Humana Press, Totowa, NJ

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    Source: Staatsbibliothek zu Berlin
    Contributor: Gott, Jonatha M. (Hrsg.)
    Language: English
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    ISBN: 1588292428
    Other identifier:
    9781588292421
    2003020827
    1-59259-775-0
    RVK Categories: WC 4150 ; WC 4460
    Series: Methods in molecular biology ; 265
    Subjects: RNA editing; RNA editing; RNA Editing; RNA Interference; RNA Editing; RNA Interference
    Scope: XIII, 435 S, Ill., graph. Darst, 24 cm
    Notes:

    Includes bibliographical references and index
  20. RNA editing
    Published: ©2007
    Publisher:  Academic Press/Elsevier, San Diego, Calif.

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    Ostbayerische Technische Hochschule Amberg-Weiden / Hochschulbibliothek Amberg
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    ISBN: 9780080551050; 008055105X; 9780123739223; 0123739225
    Series: Methods in enzymology ; v. 424
    Subjects: RNA Editing; SCIENCE / Life Sciences / Molecular Biology; RNA editing; RNA editing; Labortechnik; RNS-Edierung
    Scope: xlv, 544 pages, [10] pages of plates
    Notes:

    Includes bibliographical references and indexes

    RNA processing plays a critical role in realizing the full potential of a given genome. One means of achieving protein diversity is through RNA editing. A diverse array of editing events has been characterized, affecting gene expression in organisms from viruses and single cell parasites to humans and plants. The variety of editing mechanisms has required the development of many different experimental approaches, many of which are likely to be broadly applicable, particularly given the interplay between editing and other cellular processes, including transcription, splicing, and RNA silencing. This volume not only covers most of the principal methods employed in the field, but also offers innovative solutions to the significant challenges posed by these experimental systems. * Presents newly developed methods * Covers topics ranging from biochemistry to bioinformatics * Includes innovative solutions to potential problems
  21. RNA Editing
    Published: 2008
    Publisher:  Springer-Verlag Berlin Heidelberg, Berlin, Heidelberg

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    ISBN: 9783540737872
    Other identifier:
    RVK Categories: WG 1800-WG 1840 ; WG 1800
    Series: Nucleic Acids and Molecular Biology ; 20
    Array
    Subjects: Life sciences; Biochemistry; Cytology; Microbiology; Cytology; Life Sciences; Life Sciences; Biochemistry; Microbiology; Cytology; Cytology; RNA Editing; Biochemistry; Biochemistry, general; Biological Techniques; Cell biology; Life Sciences; Microbiology; Plant Biochemistry; RNA Editing
    Scope: Online-Ressource (XI, 231 p, digital)
    Notes:

    Includes bibliographical references and index
  22. Adenosine Deaminases Acting on RNA (ADARs) and A-to-I Editing
    Author: Samuel, Charles E.
    Published: 2012
    Publisher:  Springer-Verlag Berlin Heidelberg, Berlin, Heidelberg

    The objective of this CTMI volume is to provide readers with a foundation for understanding what ADARs are and how they act to affect gene expression and function. Because A-to-I editing may affect base-pairing and RNA structure, processes including... more

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    Universität Potsdam, Universitätsbibliothek
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    The objective of this CTMI volume is to provide readers with a foundation for understanding what ADARs are and how they act to affect gene expression and function. Because A-to-I editing may affect base-pairing and RNA structure, processes including translation, splicing, RNA replication, and miR and siRNA silencing may be affected.¡ It also is becoming increasingly apparent that ADARs may possess roles not only as enzymes that deaminate adenosine to produce inosine in RNA substrates with double-stranded character, but also as proteins independent of their catalytic property. Future studies of ADARs no doubt will provide us with additional surprises and new insights into the modulation of biological processes by the ADAR family of proteins The objective of this "CTMI" volume is to provide readers with a foundation for understanding what ADARs are and how they act to affect gene expression and function. It is becoming increasingly apparent that ADARs may possess roles not only as enzymes that deaminate adenosine to produce inosine in RNA substrates with double-stranded character, but also as proteins independent of their catalytic property. Because A-to-I editing may affect base-pairing and RNA structure, processes including translation, splicing, RNA replication, and miR and siRNA silencing may be affected. Future stud

     
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    Media type: Ebook
    Format: Online
    ISBN: 9783642228018
    Other identifier:
    RVK Categories: WD 5065
    Series: Current Topics in Microbiology and Immunology ; 353
    Array
    Subjects: Medicine; Human physiology; Biomedicine; Medicine; Human physiology; Adenosine Deaminase; RNA Editing; RNA, Double-Stranded
    Other subjects: Double-stranded RNA; Adenosine deaminase
    Scope: Online-Ressource (X, 238p. 50 illus., 28 illus. in color, digital)
    Notes:

    Description based upon print version of record

    Adenosine Deaminases Acting on RNA (ADARs) and A-to-I Editing; Preface; Contents; Contributors; 144 ADAR Proteins: Structure and Catalytic Mechanism; Abstract; 1…The Reaction Catalyzed by ADARs; 2…The ADAR Protein Structure is Modular; 3…Overview of Structure of ADAR2 Deaminase Domain; 4…H394, C451, C516: Zn2+ Binding; 4.1 E396; 4.2 T375; 4.3 R455; 5…Residues Involved in IP6 Binding; 6…Roles of Functional Groups in RNA Substrate at or Near the Deamination Site; 7…The Effect of Helix Defects; 8…Preferred Flanking Sequence; 9…A--C Mismatch at Editing Site

    10…2vprime-Hydroxyl of the Edited Nucleoside11…8-Aza Substitution at Edited Adenosine; 12…N7 of Substrate, C7 Substituents on Adenosine Analogs; 13…C6- and C2-Positions of the Edited Purine; 13.1 The ADAR Reaction Mechanism; 13.2 Dimerization; 13.3 Substrate Binding and Conformational Changes; 13.4 Deamination in the ADAR Active Site and Product Release; Acknowledgments; References; 145 ADAR Proteins: Double-stranded RNA and Z-DNA Binding Domains; Abstract; 1…Introduction; 2…Adenosine Deaminases Acting on RNA Family Members and Their Domain Organization; 3…RNA Editing Substrate

    3.1 Specificity of Editing3.2 What Makes a Good Editing Site?; 3.2.1 Preferences; 3.2.2 Selectivity; 3.3 Structures of Editing Substrates; 4…Adenosine Deaminases Acting on RNA Z-DNA Binding Domains; 4.1 Z-DNA Binding Domain: Structure and Substrate Recognition; 4.2 A Role for ADAR1 Z alpha Domain?; 4.3 How Does a Z-DNA Binding Domain Bind to Z-DNA?; 4.4 ADAR1 Z beta Domain: a Domain for Protein--Protein Interaction?; 5…Adenosine Deaminases Acting on RNA dsRNA Binding Domains; 5.1 Structural Characteristics of a dsRNA Binding Domain; 5.2 Sequence Specific Recognition with dsRBD

    5.3 How dsRBDs are Positioned on Substrate?5.4 Are the Binding Sites of ADAR dsRBDs Predictable?; 6…dsRBDs and Z-DNA Binding Domains Act on the Subcellular Localization of ADARs; 7…Concluding Remarks; Acknowledgments; References; 157 Editing of Neurotransmitter Receptor and Ion Channel RNAs in the Nervous System; Abstract; 1…Introduction; 2…Identification of A-to-I Editing Targets; 3…Mammalian ADAR Enzymes; 4…ADAR Substrates in the Central Nervous System; 4.1 Glutamate-Gated Ion Channels; 4.1.1 AMPA Receptors; 4.1.2 Kainate Receptors; 4.2 The Serotonin 2C Receptor (5HT2C)

    4.3 The alpha 3 Subunit of the GABAA Receptor (Gabra3)4.4 Voltage-gated Potassium Channel (Kv1.1); 5…Conclusions; References; 151 Modulation of MicroRNA Expression and Function by ADARs; Abstract; 1…Introduction; 2…MiRNA Biogenesis and Function; 3…Editing of MiRNAs; 3.1 Identification of Pri-MiRNA Editing Sites; 3.1.1 Systematic Surveys for MiRNA Editing Sites; 3.1.2 High-Throughput Sequencing of Mature MiRNAs; 3.2 Consequences of Pri-MiRNA Editing; 3.2.1 Effect on Drosha Cleavage; 3.2.2 Degradation of Inosine-Containing Pri-MiRNAs; 3.2.3 Effect on Dicer Cleavage; 3.2.4 Effect on RISC Loading

    3.2.5 Effect on Mature MiRNA Function
  23. Fine-tuning of RNA functions by modification and editing
    Contributor: Grosjean, Henri (Hrsg.)
    Published: 2005
    Publisher:  Springer, Berlin

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    Universitäts- und Landesbibliothek Sachsen-Anhalt / Zentrale
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    Contributor: Grosjean, Henri (Hrsg.)
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    ISBN: 3540244956; 9783540244950
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    9783540244950
    RVK Categories: WD 5355
    Series: Topics in current genetics ; 12
    Subjects: RNA editing; RNA Processing, Post-Transcriptional; Nucleosides; RNA; RNA Editing
    Scope: XIX, 442 S., Ill., graph. Darst.
  24. RNA and DNA editing
    methods and protocols
    Published: 2011
    Publisher:  Humana Pr., New York [u.a.]

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    Universitätsbibliothek Braunschweig
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    2911-5086
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    ISBN: 1617790176; 9781617790171
    RVK Categories: WC 4150 ; WG 1800
    Series: Methods in molecular biology ; 718
    Springer protocols
    Subjects: RNA editing; DNA; Genetic transcription; Nucleotide sequence; RNA Editing; Base Sequence; Transcription, Genetic
    Scope: XIII, 275 S., Ill., graph. Darst.
    Notes:

    Literaturangaben
  25. RNA editing
    current research and future trends
    Published: 2013
    Publisher:  Caister Academic Press, Norfolk

    Cellular editing of RNA can lead to the recoding of expressed sequences before they mature to their functional gene products, such as proteins or regulatory RNAs, and represents a hidden layer of genetic information and regulation. This major new... more

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    Cellular editing of RNA can lead to the recoding of expressed sequences before they mature to their functional gene products, such as proteins or regulatory RNAs, and represents a hidden layer of genetic information and regulation. This major new work presents an up-to-date overview of RNA editing. All the chapters here have been written by experts in the various research areas and describe key recent findings as well as exploring current frontiers in the mechanisms and functional roles of RNA editing

     
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    Source: Union catalogues
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    ISBN: 9781908230232
    RVK Categories: WD 5355
    Subjects: RNA editing; RNA Editing
    Scope: VI, 239 S., A1 - A6, Ill., graph. Darst.
    Notes:

    Literaturangaben