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  1. Biochemische und molekularbiologische Charakterisierung der in vitro und in vivo induzierten Interferone der Maus
    Author: Brehm, Gerhard
    Published: 1987

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    Universitätsbibliothek Erlangen-Nürnberg, Technisch-naturwissenschaftliche Zweigbibliothek
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    Source: Union catalogues
    Language: German
    Media type: Dissertation
    Subjects: Interferon; Charakterisierung; Interferon-Induktor; Maus
    Scope: 136 S., graph. Darst.
    Notes:

    Tübingen, Univ., Diss., 1987
  2. Biochemische und molekularbiologische Charakterisierung der in vitro und in vivo induzierten Interferone der Maus
    Author: Brehm, Gerhard
    Published: 1987

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    Universitätsbibliothek Bielefeld
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    Universitätsbibliothek der RPTU in Kaiserslautern
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    Source: Union catalogues
    Language: German
    Media type: Dissertation
    Format: Print
    Subjects: Interferon-Induktor; Interferon; Maus; Charakterisierung; Interferon; Maus
    Scope: 136 S. : Ill., graph. Darst.
    Notes:

    Tübingen, Univ., Diss., 1987
  3. Biochemische und molekularbiologische Charakterisierung der in vitro und in vivo induzierten Interferone der Maus
    Author: Brehm, Gerhard
    Published: 1987

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    Universitätsbibliothek Bielefeld
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    ZZ143 E1
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    Universitätsbibliothek der RPTU in Kaiserslautern
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    U 107334
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    Universitätsbibliothek Paderborn
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    Universitätsbibliothek Wuppertal
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    Source: Union catalogues
    Language: German
    Media type: Dissertation
    Subjects: Interferon; Charakterisierung; Maus; Interferon-Induktor
    Scope: 136 S., Ill., graph. Darst.
    Notes:

    Tübingen, Univ., Diss., 1987
  4. Biochemische und molekularbiologische Charakterisierung der in vitro und in vivo induzierten Interferone der Maus
    Author: Brehm, Gerhard
    Published: 1987

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    Freie Universität Berlin, Universitätsbibliothek
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    Humboldt-Universität zu Berlin, Universitätsbibliothek, Jacob-und-Wilhelm-Grimm-Zentrum
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    TU Berlin, Universitätsbibliothek
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    Source: Philologische Bibliothek, FU Berlin
    Language: German
    Media type: Dissertation
    Subjects: Interferon; Charakterisierung; Interferon-Induktor; Maus
    Scope: 136 S., graph. Darst.
    Notes:

    Tübingen, Univ., Diss., 1987
  5. Biochemische und molekularbiologische Charakterisierung der in vitro und in vivo induzierten Interferone der Maus
    Author: Brehm, Gerhard
    Published: 1987

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    TU Darmstadt, Universitäts- und Landesbibliothek - Stadtmitte
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    HS 127/148
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    Universitätsbibliothek J. C. Senckenberg, Zentralbibliothek (ZB)
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    Universitätsbibliothek Gießen
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    Universität Marburg, Universitätsbibliothek
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    Source: Union catalogues
    Language: German
    Media type: Dissertation
    Format: Print
    Subjects: Maus; Charakterisierung; Interferon; Interferon-Induktor
    Scope: 136 S., Ill., graph. Darst.
    Notes:

    Tübingen, Univ., Diss., 1987
  6. Biochemische und molekularbiologische Charakterisierung der in vitro und in vivo induzierten Interferone der Maus
    Author: Brehm, Gerhard
    Published: 1987

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    Universitätsbibliothek Freiburg
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    DS 88/1150
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    Staats- und Universitätsbibliothek Hamburg Carl von Ossietzky
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    88 U 6430
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    Badische Landesbibliothek
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    Universitätsbibliothek Stuttgart
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    Diss. 1988/628
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    Universitätsbibliothek der Eberhard Karls Universität
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    US 87.4478
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    Source: Union catalogues
    Language: German
    Media type: Dissertation
    Format: Print
    Subjects: Interferon-Induktor; ; Interferon; Maus; Charakterisierung; ; Interferon; Maus;
    Scope: 136 S., Ill., graph. Darst., 21 cm
    Notes:

    Tübingen, Univ., Diss. : 1987
  7. Liposomen als Vehikel für Antigene zur Immunisierung gegen die Tuberkulose
    Author: Bückle, Alexander
    Published: 2018
    Publisher:  Universität Ulm, Ulm

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  8. Characterization of puumala orthohantavirus - host interactions
    from the field to the bench
    Author: Binder, Florian
    Published: 02.07.2020

    Hantavirus, Clethrionomys glareolus, in-vitro Kultur, Interferon, NSs protein, Virus isolation, Zoonoses, bank vole Orthohantaviruses are rodent-borne pathogens distributed all over the world, which do not cause visible disease in their reservoir... more

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    Friedrich-Loeffler-Institut, Bundesforschungsinstitut für Tiergesundheit, Hauptbibliothek Insel Riems
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    eDiss.2020 [FLI]
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    Universitätsbibliothek Greifswald
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    Niedersächsische Staats- und Universitätsbibliothek Göttingen
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    Helmut-Schmidt-Universität, Universität der Bundeswehr Hamburg, Universitätsbibliothek
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    Staats- und Universitätsbibliothek Hamburg Carl von Ossietzky
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    Stiftung Tierärztliche Hochschule Hannover, Bibliothek
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    Hantavirus, Clethrionomys glareolus, in-vitro Kultur, Interferon, NSs protein, Virus isolation, Zoonoses, bank vole Orthohantaviruses are rodent-borne pathogens distributed all over the world, which do not cause visible disease in their reservoir host. Puumala orthohantavirus (PUUV) causes most human hantavirus disease cases in Europe and is transmitted by the bank vole (Clethrionomys glareolus). Hantaviruses have a tri-segmented genome consisting of the large (L) segment, coding for the RNA-dependent RNA polymerase (RdRP), the medium (M) segment, encoding the glycoproteins, and the small (S) segment. The S-segment contains two major overlapping open reading frames (ORF) coding for the nucleocapsid (N) protein and a non-structural (NSs) protein, a putative type I interferon (IFN-I) antagonist. To date, pathogenesis and reservoir host adaptation of hantaviruses are poorly understood due to missing adequate cell culture and animal models. In contrast to previous studies, in this work, data from spring and summer 2019 indicated a high vole abundance, a high PUUV prevalence in voles and high human incidence for some endemic regions in Germany, but elsewhere values were low to moderate. Regional and local human health institutions need to be aware about the heterogeneous distribution of human PUUV infection risk. For a better understanding of virus-host associations, two novel cell lines from bank voles and common voles each were generated and their susceptibility and replication capacities for a variety of zoonotic and non-zoonotic viruses were analyzed. The PUUV strain Vranica/Hällnäs showed ...

     
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    Source: Union catalogues
    Contributor: Ulrich, Rainer G. (AkademischeR BetreuerIn); Kochs, Georg (AkademischeR BetreuerIn)
    Language: English
    Media type: Dissertation
    Format: Online
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    Subjects: Hanta-Virus; Rötelmaus; Wühlmäuse; Interferon; Proteine; Viren; Isolierung <Mikrobiologie>; Zoonose; In-vitro-Kultur;
    Scope: 1 Online-Ressource (PDF-Datei: 165 Seiten, 40805 Kilobyte), Illustrationen (teilweise farbig), Diagramme (teilweise farbig)
    Notes:

    Literaturverzeichnis: Seite 139-148

    Dissertation, Mathematisch-Naturwissenschaftliche Fakultät der Universität Greifswald, 2021
  9. Identifizierung und Charakterisierung der vom Phosphoproteingen des Newcastle Disease Virus kodierten akzessorischen Proteine W und V
    Author: Karsunke, Julia
    Published: 20.01.2020

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    Universitätsbibliothek Greifswald
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    509/9133
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    Universitätsbibliothek Greifswald
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    509/9134
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    Source: Union catalogues
    Contributor: Mettenleiter, Thomas C. (AkademischeR BetreuerIn); Maisner, Andrea (AkademischeR BetreuerIn)
    Language: German
    Media type: Dissertation
    Format: Print
    Subjects: Geflügel; Newcastle-Krankheit; Viren; Phosphoproteine; Gen; Paramyxoviren; Proteine; Interferon; Antagonist; RNS-Edierung;
    Scope: 178 Seiten, Illustrationen (farbig), Diagramme (farbig)
    Notes:

    Literaturverzeichnis: Seite 141-157

    Dissertation, Mathematisch-Naturwissenschaftliche Fakultät der Universität Greifswald, 2020
  10. Identifizierung und Charakterisierung der vom Phosphoproteingen des Newcastle Disease Virus kodierten akzessorischen Proteine W und V
    Author: Karsunke, Julia
    Published: 20.01.2020

    Geflügel, Newcastle-Krankheit, akzessorische Proteine, IFN-Antagonist, V-Protein, W-Protein, mRNA-Editierung Like other members of the Paramyxoviridae, NDV enlarges its coding capacity by differential editing of transcripts. Due to co-transcriptional... more

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    Geflügel, Newcastle-Krankheit, akzessorische Proteine, IFN-Antagonist, V-Protein, W-Protein, mRNA-Editierung Like other members of the Paramyxoviridae, NDV enlarges its coding capacity by differential editing of transcripts. Due to co-transcriptional mRNA-editing the phosphoprotein gene encodes the phospho- (P), V-, and W protein. The three proteins share a common N-terminus but specify C-termini differing in length and amino acid composition. Whereas the expression and incorporation into NDV particles has been demonstrated for NDV P- and V proteins, evidence for the existence of a W protein was lacking. W-specific antipeptide sera were generated to analyze expression of the NDV W protein based on peptides located in the unique C-terminal W protein amino acid sequence that encompassed predicted antigenic sites. The corresponding rabbit sera enabled the detection of plasmid-expressed W protein as well as W protein expression during infection by indirect immunofluorescence and Western blot analyses. Incorporation of W protein into viral particles was indicated by Western blot and mass spectrometric analyses. In contrast, W protein was absent in infected cells and viral particles of newly generated recombinant NDV lacking W protein expression. Absence of W protein expression was achived by two different mutational approaches. Confocal microscopic analyses revealed a nuclear accumulation of W protein of NDV in infected cells, attributed to a bipartite nuclear localization sequence within its unique C-terminal part. Functionality of the NLS was confirmed by mutation of the two basic ...

     
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    Source: Union catalogues
    Contributor: Mettenleiter, Thomas C. (AkademischeR BetreuerIn); Maisner, Andrea (AkademischeR BetreuerIn)
    Language: German
    Media type: Dissertation
    Format: Online
    Other identifier:
    Subjects: Geflügel; Newcastle-Krankheit; Viren; Phosphoproteine; Gen; Paramyxoviren; Proteine; Interferon; Antagonist; RNS-Edierung;
    Scope: 1 Online-Ressource (1 PDF-Datei: 184 Seiten, 7348 Kilobyte), Illustrationen (farbig), Diagramme (farbig)
    Notes:

    Literaturverzeichnis: Seite 141-157

    Dissertation, Mathematisch-Naturwissenschaftliche Fakultät der Universität Greifswald, 2020